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123I-metaiodobenzylguanidine single-photon emission computerized tomography in brain tumors – a preliminary study

  • Clinical-Patient Studies
  • Published:
Journal of Neuro-Oncology Aims and scope Submit manuscript

Summary

Objective

123I-metaiodobenzylguanidine (MIBG) has been developed as a functional analog of the neurotransmitter norepinephrine. The success of MIBG as an imaging agent for neural crest tumors is derived from its chemical similarities to norepinephrine. The present study aimed to explore a potential of 123I-MIBG to differentiate embryonal tumors from other types of brain tumors.

Methods

Sixteen patients with brain tumors including three medulloblastomas, one neuroblastoma, six gliomas, and six meningiomas were examined with single-photon emission computerized tomography (SPECT) using 123I-MIBG. The 123I-MIBG uptake of tumors was defined as the ratios of tumor/nontumor (early and delayed T/NT) on SPECT images scanned 30 min and 6 h after intravenous injection of the tracer, respectively. Retention index was calculated as (delayed T/NT - early T/NT)/early T/NT.

Results

The T/NT ratios on the early images for embryonal tumors (medulloblastomas and neuroblastoma), gliomas, and meningiomas were 3.2±1.7 (mean±SD), 1.4±0.3, and 1.6±0.5, respectively. The early uptake was significantly higher in the embryonal tumors than in gliomas (P<0.05). Delayed T/NT ratios for embryonal tumors were increased compared to the early T/NT ratios, while in contrast delayed T/NT ratios for the other tumors remained low (1.2–1.7). The high retention indices of the embryonal tumors indicate specific uptake of 123I-MIBG in the tumors.

Conclusion

Early high accumulation and high retention on delayed imaging may indicate a possibility of 123I-MIBG SPECT in differentiating embryonal brain tumors from gliomas and meningiomas.

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Authors and Affiliations

  1. Department of Neurosurgery, Akita University School of Medicine, Akita, Japan

    Toshio Sasajima, Hiroyuki Kinouchi, Yuichiro Naitoh & Kazuo Mizoi

  2. Department of Radiology, Akita University School of Medicine, Akita, Japan

    Noriaki Tomura & Jiro Watarai

Authors
  1. Toshio Sasajima
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  2. Hiroyuki Kinouchi
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  3. Yuichiro Naitoh
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  4. Noriaki Tomura
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  5. Jiro Watarai
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  6. Kazuo Mizoi
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Corresponding author

Correspondence to Toshio Sasajima.

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Sasajima, T., Kinouchi, H., Naitoh, Y. et al. 123I-metaiodobenzylguanidine single-photon emission computerized tomography in brain tumors – a preliminary study. J Neurooncol 77, 185–191 (2006). https://doi.org/10.1007/s11060-005-9021-0

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  • DOI: https://doi.org/10.1007/s11060-005-9021-0

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