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Loss of 22q Chromosome is Related to Glioma Progression and Loss of 10q

Journal of Neuro-Oncology volume 76, pages 265–268 (2006)Cite this article

Summary

Loss of heterozygosity (LOH) of chromosome 22q has been investigated in 160 gliomas. LOH at one or more microsatellite increased with increasing grade of the tumor (P < 0.01). LOH22q was more frequent in astrocytic tumors (37%) compared to mixed or oligodendroglial tumors (21%) (P = 0.02). LOH22q was correlated to 10q loss but not to 1p or 9p loss. Taken together, these data suggest that LOH22q is an alteration associated with malignant progression of gliomas.

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Abbreviations

AII:

astrocytoma grade II

AIII:

astrocytoma grade III

GBM:

glioblastoma

OII:

oligodendroglioma grade II

OIII:

oligodendroglioma grade III

OAII:

oligoastrocytoma grade II

OAIII:

oligoastrocytoma grade III

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Affiliations

  1. Fédération de neurologie Mazarin, Groupe hospitalier Pitié-Salpétrière, 47-83 bd de l’Hôpital, 75013, Paris, France

    Florence Laigle-Donadey, Alexandra Benouaich, Khe Hoang-Xuan & Marc Sanson

  2. Université Paris P et M Curie, Unité mixte de recherche, U711 INSERM, Paris, France

    Emmanuelle Crinière, Alexandra Benouaich, Emmanuelle Lesueur, Khe Hoang-Xuan & Marc Sanson

  3. Laboratoire de Neuropathologie, Groupe hospitalier Pitié-Salpêtrière, Université Paris P et M Curie, Paris, France

    Karima Mokhtari

Authors
  1. Florence Laigle-Donadey
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  2. Emmanuelle Crinière
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  3. Alexandra Benouaich
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  4. Emmanuelle Lesueur
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  5. Karima Mokhtari
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  6. Khe Hoang-Xuan
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  7. Marc Sanson
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Correspondence to Marc Sanson.

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Laigle-Donadey, F., Crinière, E., Benouaich, A. et al. Loss of 22q Chromosome is Related to Glioma Progression and Loss of 10q. J Neurooncol 76, 265–268 (2006). https://doi.org/10.1007/s11060-005-7019-2

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  • DOI: https://doi.org/10.1007/s11060-005-7019-2

Keywords

  • chromosome 10q
  • chromosome 22q
  • glioma