Skip to main content

Advertisement

SpringerLink
Log in

Cerebellar liponeurocytoma/lipidized medulloblastoma

Case report and review of the literature

  • Clinical Study
  • Published:
Journal of Neuro-Oncology Aims and scope Submit manuscript

Abstract

Cerebellar liponeurocytoma that has been recently identified as a distinct entity by the World Health Organization is characterized by areas of lipomatous differentiation and apparently by a favorable prognosis. In this paper, we described a case of 49-year-old female showing progressive clinical course inspite of a low labeling/mitotic index. We also review the relevant literature. Although, basically all reported cases share a similar histological pattern, i.e. focal accumulations of adiposities in an otherwise typical small cell tumor like central neurocytoma, some clinical properties such as (age, proliferative potential, therapy and survival) are not uniform. The exact biological behavior of this special variant tumor is established. Yet, this needs further confirmation on a large number of cases with longer follow-up periods.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • H Budka L Chimelli (1994) ArticleTitleLipomatous medulloblastoma in adults: a new tumor type with possible favorable prognosis Hum Pathol 25 730–731 Occurrence Handle10.1016/0046-8177(94)90309-3

    Article  Google Scholar 

  • L Chimelli MD Hahn H Budka (1991) ArticleTitleLipomatous differentiation in a medulloblastoma Acta Neuropathol [Berl] 81 471–473

    Google Scholar 

  • F Soylemezoglu D Soffer B Onol Schwechhimer P Kleihues (1996) ArticleTitleLipomatous medulloblastoma in adults. A distinct clinicopathological entity Am J Surg Pathol 20 413–418

    Google Scholar 

  • DG Davis D Wilson M Schmitz WR Markesbery (1993) ArticleTitleLipidized medulloblastoma in adults Hum Pathol 24 990–995 Occurrence Handle10.1016/0046-8177(93)90113-U

    Article  Google Scholar 

  • F Giangaspero G Cenacchi F Roncaroli L Rigobello V Manetto M Gambacorta A Allegranza (1995) ArticleTitleMedullocytoma (lipidized medulloblastoma): a cerebellar neoplasm of adults with favorable prognosis Am J Surg Pathol 20 IssueID6 656–664

    Google Scholar 

  • DW Ellisson SC Zygmunt RO Weller (1993) ArticleTitleNeurocytoma/lipoma (neurolipocytoma) of the cerebellum Neuropathol Appl Neurobiol 19 IssueID1 95–98

    Google Scholar 

  • H Alkadhi M Keller S Brandner Y Yonekawa SS Kollias (2001) ArticleTitleNeuroimaging of cerebellar liponeurocytoma. Case report J Neurosurg 95 324–331

    Google Scholar 

  • R González-Cámpora RO Weller (1998) ArticleTitleLipidized mature neuroectodermal tumor of the cerebellum with myoid differentiation Neuropathol Appl Neurobiol 24 IssueID5 397–402

    Google Scholar 

  • P Kleihues L Chimelli F Giancaspero (2000) Cerebellar liponeurocytoma P Kleihues WK Cavenee (Eds) World Health Organization Classification of Tumors: Pathology and Genetics Tumors of the Nervous System IARC Press Lyon 110–111

    Google Scholar 

  • JT Bechtel JM Patton Y Takei (1978) ArticleTitleMixed mesenchymal and neuroectodermal tumor of the cerebellum Acta Neuropathol (Berl) 41 261–263

    Google Scholar 

  • A Orlandi B Marino M Brunori R Greco LG Spagnoli (1997) ArticleTitleLipomatous medulloblastoma Clin Neuropathol 16 IssueID4 175–179

    Google Scholar 

  • MT Giordana P Schiffer A Boghi P Buoncristiani F Benech (2000) ArticleTitleMedulloblastoma with lipidized cells versus lipomatous medulloblastoma Clin Neuropathol 19 IssueID6 273–277

    Google Scholar 

  • TR Jackson WF Regine D Wilson DG Davis (2001) ArticleTitleCerebellar liponeurocytoma. Case report and review of the literature J Neurosurg 95 700–703

    Google Scholar 

  • GL Taddei AM Buccoliero A Caldarella R Conti N Di Lorenzo F Cacciola A Franchi (2001) ArticleTitleCerebellar liponeurocytoma: immunohistochemical and ultrastructural study of a case Ultrastruct Pathol 25 59–63 Occurrence Handle10.1080/019131201300004690

    Article  Google Scholar 

  • MC Sharma M Agarwal A Suri S Gaikwad P Mukhopadhyay C Sarkar (2002) ArticleTitleLipomedulloblastoma in child: a controversial entity Human Pathol 33 IssueID5 564–569 Occurrence Handle1:STN:280:DC%2BD38zltVGqsw%3D%3D

    CAS  Google Scholar 

  • N Montagna D Moreira LC Vaz M Reis (2002) ArticleTitleCerebellar liponeurocytoma. A newly recognized clinico-pathological entity Arq Neuro-Psiquiatr 60 IssueID3-B 725–729

    Google Scholar 

  • JJ Kepes W Rubinstein LF Eng (1979) ArticleTitlePleomorphic xanthoastrocytoma: a distinctive meningocerebral glioma of young subjects with relatively favorable prognosis A study of 12 cases. Cancer 44 1839–1852

    Google Scholar 

  • JM Roda M Gutierrez-Molina (1995) ArticleTitleMultiple intraspinal low-grade astrocytomas mixed with lipoma (astrolipoma): case report J Neurosurg 82 891–894

    Google Scholar 

  • MM Ruchoux JJ Kepes P Dhellemmes M Hamon CA Maurage M Lecomte CM Gall J Chilton (1998) ArticleTitleLipomatous differentiation in ependymomas: a report of three cases and comparison with similar changes reported in other central nervous system neoplasms of neuroectodermal origin Am J Surg Pathol 22 338–346

    Google Scholar 

  • DS Russel LJ Rubinstein (1998) Tumors of central neuroepithelial origin DS Russel LJ Rubinstein (Eds) Pathology of Tumors of the Nervous System, 6th edn Edward Arnold London 460–470

    Google Scholar 

  • L Selassie R Rigotti JJ Kepes J Towfighi (1994) ArticleTitleAdipose tissue and smooth muscle in a primitive neuroectodermal tumor of cerebrum Acta Neuropathol (Berl) 87 217–222

    Google Scholar 

  • UE Anwer TW Smith U DeGirolami HA Wilkinson (1989) ArticleTitleMedulloblastoma with cartilaginous differentiation. Arch Pathol Lab Med 113 IssueID1 84–88

    Google Scholar 

  • PC Burger BW Scheithauer SF Vogel (2002) Small cell embryonal neoplasm PC Burger BW Scheithauer SF Vogel (Eds) Surgical Pathology of the Nervous System and Its Coverings, 4th edn Churchill Livingstone Philadelphia 298–311

    Google Scholar 

  • DW Dickson MN Hart A Menezes PA Cancilla (1983) ArticleTitleMedulloblastoma with glial and rhabdomyoblastic differentiation A myoglobulin and glial fibrillary acidic protein immunohistochemical and ultrastructural study. J Neuropathol Exp Neurol 42 639–647

    Google Scholar 

  • C Carrie C Lasset C Alapetite C Haie-Meder S Hoffstetter MC Demaille C Kerr JP Wagner JL Lagrange JP Maire (1994) ArticleTitleMultivariate analysis of prognostic factors in adult patients with medulloblastoma Retrospective study of 156 patients. Cancer 74 2352–2360

    Google Scholar 

  • DH George BW Scheithauer (2001) ArticleTitleCentral liponeurocytoma. Am J Surg Pathol 25 IssueID2 1551–1555

    Google Scholar 

  • MB Hazuka Da DeBiose RH Henderson JJ Kinzie (1992) ArticleTitleSurvival results in adult patients treated for medulloblastoma Cancer 69 2143–2148

    Google Scholar 

  • JL Hubbard BW Scheithauer DB Kispert SM Carpenter MR Wick ER Laws Jr (1989) ArticleTitleAdult cerebellar medulloblastomas: the pathological, radiographic and clinical disease spectrum J Neurosurg 70 536–544

    Google Scholar 

  • F Giancaspero SH Bigner P Kleihues (2000) Medulloblastoma P Kleihues WK Cavenee (Eds) World Health Organization Classification of Tumors Pathology and Genetics Tumors of the Nervous System. IARC Press Lyon 129–137

    Google Scholar 

  • JW Furlong (1994) DNA analysis of central nervous system. in: DF Keren CA Hanson PE Hurtubie (Eds) Flow Cytometry and Clinical Diagnosis. ASCP Press Chicago 567

    Google Scholar 

  • T Tomita M Yasue HH Engelhard DG McLone F Gonzalez-Crussi KD Bauer (1988) ArticleTitleFlow Cytometric DNA analysis of medulloblastoma Cancer 61 744–749 Occurrence Handle1:STN:280:BieC3cbis1A%3D Occurrence Handle3338037

    CAS  PubMed  Google Scholar 

  • M Yasue T Tomita H Engelhard F Gonzalez-Crussi DG McLone KD Bauer (1989) ArticleTitlePrognostic importance of DNA ploidy in medulloblastoma in childhood J Neurosurg 70 385–391

    Google Scholar 

  • C Zerbini RD Gelber D Weinberg SE Sallan P Barnes W Kupsky RM Scott NJ Tarbell (1993) ArticleTitlePrognostic factors in medulloblastoma, including DNA ploidy J Clin Oncol 11 616–622

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pathology, Haydarpasa Numune Education and Research Hospital, Turkey

    Fügen Vardar Aker, Selvinaz Özkara & Önder Peker

  2. Department of Moleculer Pathology, Haydarpasa Numune Teaching and Research Hospital, Marmara University Medical Biology and Genetic Department, Turkey

    Pinar Eren

  3. Department of Neurosurgery, Haydarpasa Numune Teaching and Research Hospital, Istanbul, Turkey

    Serdar Armağan & Tayfun Hakan

  4. 81140, Karayollari Site Sok, Barbaros Mah, Soyak Gokyuzu Konutlari, A-Blok No. 29, Altunizade-Uskudar-Istanbul, Turkey

    Fügen Vardar Aker

Authors
  1. Fügen Vardar Aker
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Selvinaz Özkara
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Pinar Eren
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Önder Peker
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Serdar Armağan
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Tayfun Hakan
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Fügen Vardar Aker.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Aker, F.V., Özkara, S., Eren, P. et al. Cerebellar liponeurocytoma/lipidized medulloblastoma. J Neurooncol 71, 53–59 (2005). https://doi.org/10.1007/s11060-004-9172-4

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11060-004-9172-4

Keywords

Search

Navigation