Skip to main content

Gliomatosis Cerebri and Pituitary Adenoma: Case Report and Literature Review

Journal of Neuro-Oncology volume 74, pages 321–324 (2005)Cite this article

Summary

The diagnosis of Gliomatosis cerebri (GC) is known to be difficult and is still a matter of debate. We describe an in␣vivo case of GC associated with a pituitary tumor. A 47-year-old woman presented with short-term memory loss. A MRI revealed the presence of a pituitary enhancing tumor and a diffuse lesion involving the brain. A left pterional craniotomy with partial temporal lobectomy and removal of the pituitary lesion were performed in order to obtain diagnosis. The histological analyses showed a pituitary non-functioning tumor and a GC consisting of neoplastic oligodendrocytes and astrocytes. Both lesions showed nuclear immunoreactivity for progesterone receptors (PGr) and estrogen receptors (EGr). This result could suggest there is a common receptor substrate in these tumors. In this case hormones could constitute a common step in tumorigenesis of both lesions.

This is a preview of subscription content, access via your institution.

Access options

Buy single article

Instant access to the full article PDF.

43,34 €

Price includes VAT (Finland)
Tax calculation will be finalised during checkout.

References

  • P Kleihues WK Cavenee (2000) World Health Organization Classification of Tumors.Pathology and Genetics of Tumours of the Nervous System IARC press Lyon

    Google Scholar 

  • MT Jennings M Frenchman T Shehab MD Johnson J Creasy K LaPorte WD Dettbarn (1995) ArticleTitleGliomatosis cerebri presenting as intractable epilepsy during early childhood J Child Neurol 10 37–45

    Google Scholar 

  • S Nevin (1938) ArticleTitleGliomatosis cerebri Brain 61 170–191

    Google Scholar 

  • IM Scheinker JP Evans (1943) ArticleTitleDiffuse cerebral glioblastosis J Neuropathol Exp Neurol 2 178–189

    Google Scholar 

  • S Santos et al. (2002) ArticleTitleGliomatosis cerebral. Presentation de tres casos y revision de la literatura Rev Neurol 34 IssueID3 248–252 Occurrence Handle12022073

    PubMed  Google Scholar 

  • A Iglesias M Garcia JS Millan C Villanueva G Fraile M Serrano (1997) ArticleTitleGliomatosis cerebri mimicking a metastatic breast cancer: fatal outcome J Neurooncol 32 175–178 Occurrence Handle10.1023/A:1005779919226 Occurrence Handle9120548

    Article  PubMed  Google Scholar 

  • C Onal C Bayindir (1999) ArticleTitleGliomatosis cerebri with neurofibromatosis: an autopsy-proven case Childs Nerv Syst 15 219–221 Occurrence Handle10.1007/s003810050376 Occurrence Handle10392491

    Article  PubMed  Google Scholar 

  • PG Barth FC Stam W Hack HA Delemarre-vande Waal (1988) ArticleTitleGliomatosis cerebri in a newborn Neuropediatrics 19 IssueID4 197–200 Occurrence Handle3205377

    PubMed  Google Scholar 

  • P Peretti-Viton H Brunel O Chinot C Daniel M Barrié D Figarella-Brnger S Fuentes F Grisoli (2002) ArticleTitleHistological and MR corelations in Gliomatosis cerebri J Neurooncol 59 249–259 Occurrence Handle10.1023/A:1019934901750 Occurrence Handle12241123

    Article  PubMed  Google Scholar 

  • E Rivas J Guzman E Mora-La Cruz (1995) ArticleTitleGliomatosis cerebri. Determination antemortem Invest Clin 36 IssueID3 149–157 Occurrence Handle7548307

    PubMed  Google Scholar 

  • H Nishioka H Ito T Miki (1996) ArticleTitleDifficulties in the antemortem diagnosis of gliomatosis cerebri: report of a case with diffuse increase of gemistocyte-like cells mimicking reactive gliosis Br J Neurosurg 10 103–107

    Google Scholar 

  • A Tancredi A Mangiola A Guiducci A Peciarolo P Ottaviano (2000) ArticleTitleOligodendrocytic gliomatosis cerebri Acta Neurochir 142 469–472 Occurrence Handle10.1007/s007010050459

    Article  Google Scholar 

  • IB Ross Y Robitaille JC Villemure D Tampieri (1991) ArticleTitleDiagnosis and management of gliomatosis cerebri: recent trends Surg Neurol 36 431–440 Occurrence Handle10.1016/0090-3019(91)90156-4 Occurrence Handle1759182

    Article  PubMed  Google Scholar 

  • N Hejazi A Witzmann K Hergan (2001) ArticleTitleGliomatosis cerebri: intra vitam stereotactic determination in two cases and review of the literature Br J Neurosurg 15 IssueID5 396–401 Occurrence Handle10.1080/02688690120082396 Occurrence Handle11708542

    Article  PubMed  Google Scholar 

  • MV Spagnoli RI Grossman RJ Packer DB Hackney HI Goldberg RA Zimmerman et al. (1987) ArticleTitleMagnetic Resonance Imaging deermination of gliomatosis cerebri Neuroradiology 29 15–18 Occurrence Handle10.1007/BF00341031 Occurrence Handle3822096

    Article  PubMed  Google Scholar 

  • G Balko KS Blisard FJ Samaha (1992) ArticleTitleOligodendroglial gliomatosis cerebri Hum Pathol 23 IssueID6 706–707 Occurrence Handle10.1016/0046-8177(92)90329-2 Occurrence Handle1592395

    Article  PubMed  Google Scholar 

  • Schober R, Mai JK, Volk B, Wechsler W: Gliomatosis cerebri: bioptical approach and neuropathological verification. Acta Neurochir 113:131–137

  • R Abs M Vyve Particlevan PJ Willems I Neetens B Auwera Particlevan der E Ende Particlevan der E Vande Kelft A Beckers E Marck Particlevan JJ Martin (1992) ArticleTitleThe association of astrocytoma and pituitary adenoma in a patient with alcaptonuria J Neurol Sci 108 32–34 Occurrence Handle10.1016/0022-510X(92)90184-M Occurrence Handle1624949

    Article  PubMed  Google Scholar 

  • HG Deen ER Laws (1981) ArticleTitleMultiple primary brain tumors of different cell types Neurosurgery 8 IssueID1 20–25 Occurrence Handle6259551

    PubMed  Google Scholar 

  • M Ezura T Kayama A Ogawa T Wada (1988) ArticleTitleA case of anaplastic astrocytoma associated with pituitary adenoma (Japanese) No Shinkei Geka 16 1505–1509 Occurrence Handle3226501

    PubMed  Google Scholar 

  • BL Wise N Malamud EB Boldrey (1953) ArticleTitleMultiple intracranial tumors: glioma associated with hypophyseal chromophobe adenoma. A report of two cases J Neuropathol Exp Neurol 12 224–231 Occurrence Handle13061970

    PubMed  Google Scholar 

  • CF List JR Williams (1952) ArticleTitleVascular lesions in pituitary adenomas J Neurosurg 9 177–187 Occurrence Handle14908652

    PubMed  Google Scholar 

  • RS Mc Phedran MI Tom (1962) ArticleTitlemultiple primary intracranial tumors. A case report Neurology 12 524–528

    Google Scholar 

  • BN Tsybel V Solodun (1985) ArticleTitleCombination of malignant pituitary adenoma and astrocytoma (Russian) Arkh Pathol 47 60–62

    Google Scholar 

  • S Inagawa H Yamakawa M Nishikawa (1994) ArticleTitleTriple brain tumors of different histological types:case report Surg Neurol 41 52–55 Occurrence Handle10.1016/0090-3019(94)90208-9 Occurrence Handle8310388

    Article  PubMed  Google Scholar 

  • S Waga H Handa (1976) ArticleTitleRadiation-induced meningioma: with review of literature Surg Neurol 5 215–219 Occurrence Handle817405

    PubMed  Google Scholar 

  • IR Whittle RA Hawkins JD Miller (1987) ArticleTitleSex hormone receptors in intracranial tumors and normal brain Eur J Surg Oncol 13 IssueID4 303–307 Occurrence Handle3622783

    PubMed  Google Scholar 

  • ML Jaffrain-Rea E Petrangeli F Ortolani B Fraioli A Lise V Esposito LG Spagnoli G Tamburrano L Frati A Gulino (1996) ArticleTitleCellular receptors for sex steroids in human pituitary adenomas J Endocrinol 151 IssueID2 175–184 Occurrence Handle10.1677/joe.0.1510175 Occurrence Handle8958777

    Article  PubMed  Google Scholar 

  • GA Machiavelli CM Rivolta R Artese A Basso JA Burdman (1998) ArticleTitleExpression of c-myc and c-fos and binding sites for estradiol and progesterone in human pituitary tumors Neurol Res 20 IssueID8 709–712 Occurrence Handle9864735

    PubMed  Google Scholar 

  • JW Ironside VJ dangerfield WR Timperley JC Underwood (1986) ArticleTitleSteroid hormone receptors in pituitary adenomas: a biochemical, immunoistochemical and morphometric study on cryostat sections Neuropathol Appl Neurobiol 12 IssueID6 539–546 Occurrence Handle3561690

    PubMed  Google Scholar 

  • RS Carrol J Zhang K Dashner M Sar P Black (1995) ArticleTitleSteroid hormone receptors in astrocytic neoplasms Neurosurgery 37 IssueID3 496–503 Occurrence Handle7501116

    PubMed  Google Scholar 

  • RR Stojkovic M Jovancevic DJ Santel N Grcevic S Gamulin (1990) ArticleTitleSex steroid receptors in intracranial tumors Cancer 65 1968–1970 Occurrence Handle2372766

    PubMed  Google Scholar 

  • P Paoletti G Butti C Zibera M Scerrati N Gibelli R Roselli L Magrassi G Sica G Rossi G Robustellidella Cuna (1990) ArticleTitleCharacteristics and biological role of steroid hormone receptors in neuro epithelial tumors J Neurosurg 73 736–742 Occurrence Handle2134312

    PubMed  Google Scholar 

  • R Martinez ML Marcos A Figueras J Vaquero (1984) ArticleTitleEstrogen and progesterone receptors in intracranial tumors Clin Neuropharmacol 7 IssueID4 338–342 Occurrence Handle6509443

    PubMed  Google Scholar 

  • MM Brentani MTP Lopes VR Martins JPP Plese (1984) ArticleTitleSteroid receptors in intracranial tumors Clin Neuropharmacol 7 IssueID4 347–350 Occurrence Handle6509445

    PubMed  Google Scholar 

  • M Fujimoto E Yoshino K Hirakawa J Fujimoto T Tamaya (1984) ArticleTitleEstrogen receptors in brain tumors Clin Neuropharmacol 7 IssueID4 357–362 Occurrence Handle6509447

    PubMed  Google Scholar 

  • H Khalid S Shibata M Kishikawa A Yasunaga M Iseki T Hiura (1997) ArticleTitleImmunoistochemical analysis of progesterone receptor and Ki-67 labeling index in astrocytic tumors Cancer 80 2133–2140 Occurrence Handle10.1002/(SICI)1097-0142(19971201)80:11<2133::AID-CNCR13>3.0.CO;2-# Occurrence Handle9392336

    Article  PubMed  Google Scholar 

Download references

Author information

Affiliations

  1. Institute of Neurosurgery, Catholic University School of Medicine, Largo A. Gemelli 8, 00168, Rome, Italy

    A. Mangiola, P. De. Bonis, A. Pompucci & C. Anile

  2. Institute of Pathology, Catholic University School of Medicine, Rome, Italy

    M. Guerriero

Authors
  1. A. Mangiola
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. P. De. Bonis
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. M. Guerriero
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. A. Pompucci
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. C. Anile
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to A. Mangiola.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Mangiola, A., Bonis, P.D., Guerriero, M. et al. Gliomatosis Cerebri and Pituitary Adenoma: Case Report and Literature Review. J Neurooncol 74, 321–324 (2005). https://doi.org/10.1007/s11060-004-7901-3

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11060-004-7901-3

Keywords

  • estrogen receptor
  • gliomatosis cerebri
  • MRI
  • pituitary adenoma
  • progesterone receptor