Skip to main content

Advertisement

SpringerLink
Log in

Intracavitary Chemotherapy (Paclitaxel/Carboplatin Liquid Crystalline Cubic Phases) for Recurrent Glioblastoma – Clinical Observations

  • Clinical Study
  • Published:
Journal of Neuro-Oncology Aims and scope Submit manuscript

Summary

Human malignant brain tumors have a poor prognosis in spite of surgery and radiation therapy. Cubic phases consist of curved biocontinuous lipid bilayers, separating two congruent networks of water channels. Used as a host for cytotoxic drugs, the gel-like matrix can easily be applied to the walls of a surgical resection cavity. For human glioblastoma recurrences, the feasibility, safety, and short-term effects of a surgical intracavitary application of paclitaxel and carboplatin encapsulated by liquid crystalline cubic phases are examined in a pilot study. A total of 12 patients with a recurrence of a glioblastoma multiforme underwent re-resection and received an intracavitary application of paclitaxel and carboplatin cubic phases in different dosages. Six of the patients received more than 15 mg paclitaxel and suffered from moderate to severe brain edema, while the remaining patients received only a total of 15 mg paclitaxel. In the latter group, brain edema was markedly reduced and dealt medically. Intracavitary chemotherapy in recurrent glioblastoma using cubic phases is feasible and safe, yet the clinical benefit remains to be examined in a clinical phase II study.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. H Brem S Piantadosi PC Burger M Walker R Selker NA Vick K Black M Sisti S Brem G Mohr P Muller R Morawetz SC. Schold (1995) ArticleTitlePlacebo-controlled trial of safety and efficacy of intraoperative controlled delivery by biodegradable polymers of chemotherapy for recurrent gliomas The Polymer Brain Tumor Treatment Group. Lancet 345 1008–1012

    Google Scholar 

  2. B Ericsson PO. Eriksson (1991) ArticleTitleCubic phases as delivery systems for peptide drugs Polym Drugs Drug Deliv Syst 469 251–265

    Google Scholar 

  3. A Pampel D Michel R. Reszka (2002) ArticleTitlePulsed field gradient MAS-NMR studies of the mobility of carboplatin in cubic liquid-crystalline phases Chem Phys Lett 357 131–136 Occurrence Handle10.1016/S0009-2614(02)00468-2

    Article  Google Scholar 

  4. DM Wyatt D. Dorschel (1992) ArticleTitleCubic phase delivery system composed of glyceryl monooleate and water for sustained release of water soluble drugs Pharm Tech 16 116–130

    Google Scholar 

  5. PO Eriksson G. Lindblom (1993) ArticleTitleLipid and water diffusion in biocontinuous cubic phases measured by NMR Biophys J 64 129–136 Occurrence Handle8431537

    PubMed  Google Scholar 

  6. K Larsson K Fontell N. Krog (1980) ArticleTitleStructural relationship between lamellar, cubic and hexagonal phases in monoglyeride–water systems. Possibility of cubic structures in biological systems Chem Phys Lipids 27 321–328 Occurrence Handle10.1016/0009-3084(80)90026-2

    Article  Google Scholar 

  7. A Tardieu V. Luzzati (1970) ArticleTitlePolymorphism of lipids. A novel cubic phase – a cage-like network of rods with enclosed spherical micelles Biochem Biophys Acta 219 11–17 Occurrence Handle5473499

    PubMed  Google Scholar 

  8. S. Engstrom (1990) ArticleTitleCubic phases as drug delivery systems Polym Prep (Am Chem Soc, Div Polym Chem) 31 157–158

    Google Scholar 

  9. JC Shah Y Sadhale DM. Chilukuri (2001) ArticleTitleCubic phase gels as drug delivery systems Adv Drug Deliv Rev 47 229–250 Occurrence Handle10.1016/S0169-409X(01)00108-9 Occurrence Handle11311994

    Article  PubMed  Google Scholar 

  10. AI Qureshi MF Suri J Khan M Sharma K Olson LP Guterman LN. Hopkins (2001) ArticleTitleSuperselective intra-arterial carboplatin for treatment of intracranial neoplasma: experience in 100 procedures J Neurooncol 51 151–158 Occurrence Handle10.1023/A:1010683128853 Occurrence Handle11386412

    Article  PubMed  Google Scholar 

  11. A Olivi MG Ewend T Utsuki B Tyler AJ Domb DJ Brat H. Brem (1996) ArticleTitleInterstitial delivery of carboplatin via biodegradable polymers is effective against experimental glioma in rat Cancer Chemother Pharmacol 39 90–96

    Google Scholar 

  12. Limentani SA, Asher A, Heafner M, Kim JW, Fraser R: A phase I trial of surgery, Gliadel wafer implantation, and immediate postoperative carboplatin in combination with radiation therapy for primary anaplastic astrocytoma or glioblastoma multiforme. J Neurooncol 2004 (accepted)

  13. CA Hurwitz LC Strauss J Kepner C Kretschmar MB Harris H Friedman L Kun R. Kadota (2001) ArticleTitlePaclitaxel for the treatment of progressive or recurrent childhood brain tumors: a pediatric oncology phase II study J Pediatr Hematol Oncol 23 277–281 Occurrence Handle10.1097/00043426-200106000-00008 Occurrence Handle11464982

    Article  PubMed  Google Scholar 

  14. MC Chamberlain P. Kormanik (1999) ArticleTitleSalvage chemotherapy with taxol for recurrent anaplastic astrocytoma J Neurooncol 43 269–276 Occurrence Handle10.1023/A:1006262720665 Occurrence Handle10563433

    Article  PubMed  Google Scholar 

  15. MD Prados SC Schold AM Spence MS Berger LD McAllister MP Mehta MR Gilbert D Fulton J Kuhn K Lamborn DJ Rector SM. Chang (1996) ArticleTitlePhase II study of paclitaxel in patients with recurrent malignant glioma J Clin Oncol 14 2316–2321 Occurrence Handle8708723

    PubMed  Google Scholar 

  16. SM Chang JG Kuhn HI Robins SC Schold SuffixJr AM Spence MS Berger M Metha IF Pollack C Rantin MD. Prados (2001) ArticleTitleA phase II study of paclitaxel in patients with recurrent malignant glioma using different doses depending upon the concomitant use of anticonvulsants: A North American Brain Tumor Consortium report Cancer 91 417–422 Occurrence Handle10.1002/1097-0142(20010115)91:2<417::AID-CNCR1016>3.0.CO;2-9 Occurrence Handle11180089

    Article  PubMed  Google Scholar 

  17. KA Walter MA Cahan A Gur B Tyler J Hilton OM Colvin PC Burger A Domb H. Brem (1994) ArticleTitleInterstitial taxol delivered from a biodegradable polymer implant against experimental malignant glioma Cancer Res 54 2207–2212 Occurrence Handle7909720

    PubMed  Google Scholar 

  18. CM Spencer D. Faulds (1994) ArticleTitlePaclitaxel: a review of its pharmacodynamic and pharmacokinetic properties and therapeutic potentials in the treatment of cancer Drugs 48 794–847 Occurrence Handle7530632

    PubMed  Google Scholar 

  19. von Eckardstein K, Patt S, Kratzel C, Kiwit JCW, Reszka R: Local chemotherapy of F98 rat glioblastoma with paclitaxel and carboplatin embedded in liquid crystalline cubic phases. J Neurooncol 2004 (accepted)

  20. U Gatzemeier J Pawel Particlevon M Gottfried GP ten Velde K Mattson F DeMarinis P Harper F Salvati G Robinet A Lucenti J Bogaerts G. Gallant (2001) ArticleTitlePhase III comparative study of high-dose cisplatin versus a combination of paclitaxel and cisplatin in patients with advanced non-small cell lung cancer J Clin Oncol 19 2108–2109 Occurrence Handle11283150

    PubMed  Google Scholar 

  21. FM Muggia PS Braly MF Brady G Sutton TH Niemann SL Lentz RD Alvarez PR Kucera JM. Small (2000) ArticleTitlePhase III randomized study of cisplatin versus paclitaxel versus cisplatin and paclitaxel in patients with suboptimal stage III or IV ovarian cancer: a gynecologic oncology study group J Clin Oncol 18 106–115 Occurrence Handle10623700

    PubMed  Google Scholar 

  22. AB Miller B Hoogstraten M Staquet A. Winkler (1981) ArticleTitleReporting results of cancer treatment Cancer 47 207–214 Occurrence Handle7459811

    PubMed  Google Scholar 

  23. LC Marras WH Geerts JR. Perry (2000) ArticleTitleThe risk of venous thrombembolism is increased throughout the course of malignant glioma: an evidence-based review Cancer 89 640–646 Occurrence Handle10.1002/1097-0142(20000801)89:3<640::AID-CNCR20>3.0.CO;2-E Occurrence Handle10931464

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Neurosurgery, HELIOS Klinikum Berlin, Klinikum Buch, Hobrechtsfelder Chaussee 96, 13125, Berlin, Germany

    Kajetan L. von Eckardstein & Jürgen C. W. Kiwit

  2. Max-Delbrück-Center for Molecular Medicine, Berlin, Germany

    Regina Reszka

Authors
  1. Kajetan L. von Eckardstein
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Regina Reszka
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Jürgen C. W. Kiwit
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Kajetan L. von Eckardstein.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Eckardstein, K.L.v., Reszka, R. & Kiwit, J.C.W. Intracavitary Chemotherapy (Paclitaxel/Carboplatin Liquid Crystalline Cubic Phases) for Recurrent Glioblastoma – Clinical Observations. J Neurooncol 74, 305–309 (2005). https://doi.org/10.1007/s11060-004-7559-x

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11060-004-7559-x

Keywords

Search

Navigation