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CXCL12 Expression is Predictive of a Shorter Time to Tumor Progression in Low-Grade Glioma: A Single-Institution Study in 50 Patients

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Summary

The clinical course of 50 patients with low-grade glioma (31 male, 19 female) undergoing surgery at a single Institution from 1992 to 1996 was analyzed in relationship with known prognostic factors as far as time to tumor progression (TTP) and survival time (ST) are concerned. Moreover, microvessel density (MVD) and expression of the angiogenesis-related chemokine CXCL12 were investigated in surgical specimens. Age at diagnosis ranged from 1 to 68 years (median 30). Histology revealed 11 fibrillary, 6 protoplasmatic, 5 gemistocytic astrocytoma, 18 oligoastrocytoma and 10 oligodendroglioma. Mean follow-up was 86 months. Four patients were lost to follow-up. Of the remaining 46, twenty-four have shown disease progression and 14 have died. Median overall survival was not achieved; an estimated 75% percentage of survivors was found at 78 months. Complete gross tumor removal was associated to a longer TTP (P = 0.04 logrank). Of the investigated immunohistochemical parameters, while MVD was not predictive of subsequent TTP, expression of CXCL12 was associated with a significantly shorter TTP (P = 0.01 logrank): this predictive value remained significant (P = 0.02) at multivariate analysis. The data suggest the possible prognostic value for CXCL-12 (an angiogenesis- and tumor-growth-related chemokine) on TTP in low-grade gliomas.

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References

  1. JG Cairncross K Ueki MC Zlatescu DK Lisle DM Finkelstein RR Hammond JS Silver PC Stark DR MacDonald Y Ino DA Ramsay DN. Louis (1998) ArticleTitleSpecific genetic predictors of chemotherapeutic response and survival in patients with anaplastic oligodendrogliomas J Natl Cancer Inst. 90 1473–1479 Occurrence Handle10.1093/jnci/90.19.1473 Occurrence Handle9776413

    Article  PubMed  Google Scholar 

  2. L Bissola M Eoli B Pollo BM Merciai A Silvani E Salsano C Maccagnano MG Bruzzone AM Fuhrman Conti CL Solero S Giombini G Broggi A Boiardi G. Finocchiaro (2002) ArticleTitleAssociation of chromosome losses and negative prognosis in oligoastrocytomas Ann Neurol 52 IssueID6 842–845 Occurrence Handle10.1002/ana.10405 Occurrence Handle12447941

    Article  PubMed  Google Scholar 

  3. M Nakamura N Konishi S Tsunoda H Nakase T Tsuzuki H Aoki H Sakitani T Inui T. Sakaki (2000) ArticleTitleAnalysis of prognostic and survival factors related to treatment of low-grade astrocytomas in adults Oncology. 58 108–116 Occurrence Handle10.1159/000012087 Occurrence Handle10705237

    Article  PubMed  Google Scholar 

  4. C Komine T Watanabe Y Katayama A Yoshino T Yokohsms T. Fukushima (2003) ArticleTitlePromoter hypermethylation of the DNA repair gene O 6-methylguanine-DNA methyltransferase is an independent predictor of shortened progression free survival in patients with low-grade diffuse astrocytomas Brain Pathol. 13 IssueID2 176–184 Occurrence Handle12744471

    PubMed  Google Scholar 

  5. SI Abdulrauf K Edvardsen KL Ho XY Yang JP Rock ML. Rosenblum (1998) ArticleTitleVascular endothelial growth factor expression and vascular density as prognostic markers of survival in patients with low-grade astrocytoma J Neurosurg 88 513–520 Occurrence Handle9488306

    PubMed  Google Scholar 

  6. RD Oehring M Miletic MM Valter T Pietsch J Neumann R Fimmers U. Schlegel (1999) ArticleTitleVascular endothelial growth factor – VEGF – in astrocytic gliomas: a prognostic factor?. J Neuro-Oncol 45 117–125 Occurrence Handle10.1023/A:1006333005563

    Article  Google Scholar 

  7. J Vaquero M Zurita C Morales S. Coca (2000) ArticleTitlePrognostic significance of clinical and angiogenesis-related factors in low-grade oligodendrogliomas Surg Neurol 54 229–234 Occurrence Handle10.1016/S0090-3019(00)00303-7 Occurrence Handle11118569

    Article  PubMed  Google Scholar 

  8. J Vaquero M Zurita C Morales S. Coca (2001) ArticleTitlePrognostic significance of the endothelial surface in low-grade resected oligodendrogliomas Br J Neurosurg. 15 247–250 Occurrence Handle10.1080/02688690120057673 Occurrence Handle11478061

    Article  PubMed  Google Scholar 

  9. SA Rempel S Dudas S Ge JA. Gutierrez (2000) ArticleTitleIdentification and localization of the cytokine SDF1 and its receptor, CXC chemokine receptor 4, to regions of necrosis and angiogenesis in human glioblastoma Clin Cancer Res 6 IssueID1 102–111 Occurrence Handle10656438

    PubMed  Google Scholar 

  10. Y Zhou PH Larsen C Hao VW. Yong (2002) ArticleTitleCXCR4 is a major chemokine receptor on glioma cells and mediates their survival J Biol Chem. 277 IssueID51 49481–49487 Occurrence Handle10.1074/jbc.M206222200 Occurrence Handle12388552

    Article  PubMed  Google Scholar 

  11. C Giannini BW Scheithauer PC Burger MR Christensen M Wollan TJ Sebo PA Forsyth CJ. Hayostek (1999) ArticleTitleCellular proliferation in pilocytic and diffuse astrocytomas J Neuropathol Exp Neurol. 58 46–53 Occurrence Handle10068313

    PubMed  Google Scholar 

  12. PK Sallinen SL Sallinen PT Helèn S Rantala E Rautiainen HJ Helin H Kalimo HK. Haapasalo (2000) ArticleTitleGrading of diffusely infiltrating astrocytomas by quantitative histopathology, cell proliferation and image cytometric DNA analysis Neuropathol Appl Neurobiol. 26 319–331 Occurrence Handle10.1046/j.1365-2990.2000.00240.x Occurrence Handle10931365

    Article  PubMed  Google Scholar 

  13. Stupp R, Janzer RC, Hegi M, Villemure J-G, Mirimanoff RO: Prognostic factors for low-grade gliomas. Seminars in Oncology 30(6, Suppl 19): 23-28

  14. J Piepmeier S Christopher D Spencer T Byrne J Kim JP Knisel J Lacy L Tsukerman R. Makuch (1996) ArticleTitleVariations in the natural history and survival of patients with supratentorial low-grade astrocytomas Neurosurgery. 38 872–887 Occurrence Handle10.1097/00006123-199605000-00002 Occurrence Handle8727811

    Article  PubMed  Google Scholar 

  15. A Peraud H Ansari K Bise HJ. Reulen (1998) ArticleTitleClinical outcome of supratentorial astrocytoma WHO grade II Acta Neurochir (Wien) 140 1213–1222 Occurrence Handle10.1007/s007010050241

    Article  Google Scholar 

  16. A Nicolato MA Gerosa P Fina P Iuzzolino F Giorgiutti A. Bricolo (1995) ArticleTitlePrognostic factors in low-grade supratentorial astrocytomas: a uni-multivariate statistical analysis in 76 surgically treated adult patients Surg Neurol. 44 208–223 Occurrence Handle10.1016/0090-3019(95)00184-0 Occurrence Handle8545771

    Article  PubMed  Google Scholar 

  17. F Pignatti M Bent Particlevan den D Curran C Debruyne R Sylvester P Therasse D Afra P Cornu M Bolla C Vecht AB. Karim (2002) ArticleTitleMF for the European Organization for research and treatment of cancer brain tumor cooperative group and radiotherapy cooperative group J Clin Oncol 20 2076–2084 Occurrence Handle10.1200/JCO.2002.08.121 Occurrence Handle11956268

    Article  PubMed  Google Scholar 

  18. EG Shaw BW Scheithauer JR. O’Fallon (1997) ArticleTitleSupratentorial gliomas: a comparative study by grade and histologic type J Neurooncol. 31 273–278 Occurrence Handle10.1023/A:1005715703598 Occurrence Handle9049856

    Article  PubMed  Google Scholar 

  19. B Donahue CB Scott JS Nelson M Rotman KJ Murray DF Nelson FL Banker JD Earle JA Fischbach SO Asbell LE Gaspar AM Markoe W. Curran (1997) ArticleTitleInfluence of an oligodendroglial component on the survival of patients with anaplastic astrocytomas: a report of radiation therapy oncology group 83-02 Int J Radiat Oncol Biol Phys. 38 911–914 Occurrence Handle10.1016/S0360-3016(97)00126-0 Occurrence Handle9276354

    Article  PubMed  Google Scholar 

  20. AB Karim D Afra P Cornu N Bleehan S Schraub O De Witte F Dar S Stenning M Pierart M. Van Glabbeke (2002) ArticleTitleRandomized trial on the efficacy of radiotherapy for cerebral low-grade glioma in the adult: European Organization for Research and Treatment of Cancer Study 22845 with the Medical Research Council study BR04: an interim analysis Int J Radiat Oncol Biol Phys 52 IssueID2 316–324 Occurrence Handle10.1016/S0360-3016(01)02692-X Occurrence Handle11872276

    Article  PubMed  Google Scholar 

  21. A Boiardi M Eoli A Salmaggi B Pollo I Milanesi G Broggi A: Silvani (2000) ArticleTitleCisplatin and BCNU chemotherapy for anaplastic oligoastrocytomas J Neurooncol 49 IssueID1 71–75 Occurrence Handle10.1023/A:1006489919811 Occurrence Handle11131989

    Article  PubMed  Google Scholar 

  22. RA Kristof G Neuloh V Hans M Deckert H Urbach U Schlegel M Simon J. Schramm (2002) ArticleTitleCombined surgery, radiation, and PCV chemotherapy for astrocytomas compared to oligodendrogliomas and oligoastrocytomas WHO grade III J Neurooncol. 59 IssueID3 231–237 Occurrence Handle10.1023/A:1019987116596 Occurrence Handle12241120

    Article  PubMed  Google Scholar 

  23. M Werner Wasik CB Scott DF Nelson LE Gaspar KJ Murray JA Fischbach JS Nelson AS Weinstein W Curran SuffixJr. (1996) ArticleTitleFinal report of a phase I/II trial of hyperfractionated radioation therapy with carmustine for adults with supratentorial malignant gliomas: RTOG Study 83-02 Cancer 77 1535–1543 Occurrence Handle10.1002/(SICI)1097-0142(19960415)77:8<1535::AID-CNCR17>3.0.CO;2-0 Occurrence Handle8608540

    Article  PubMed  Google Scholar 

  24. S Barbero R Bonavia A Bajetto C Porcile P Pirani JL Ravetti GL Zona R Spaziante T Florio G. Schettini (2003) ArticleTitleStromal cell-derived factor 1alfa stimulates human glioblastoma cell growth through the activation of both extracellular signal-regulated kinases ½ and Akt Cancer Res. 63 1969–1974 Occurrence Handle12702590

    PubMed  Google Scholar 

  25. A Salmaggi M Gelati B Pollo S Frigerio M Eoli A Silvani G Broggi E Ciusani D Croci A Boiardi M. De Rossi (2004) ArticleTitleCXCL12 in malignant glial tumors: a possibile role in angiogenesis and cross-talk between endothelial and tumoral cells J Neurooncol 67 305–317 Occurrence Handle10.1023/B:NEON.0000024241.05346.24 Occurrence Handle15164986

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Istituto Nazionale Neurologico C.Besta, Via Celoria 11, 20133, Milano, Italy

    A. Salmaggi, M. Gelati, B. Pollo, C. Marras, A. Silvani, M. R. Balestrini, M. Eoli, L. Fariselli, G. Broggi & A. Boiardi

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  1. A. Salmaggi
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  2. M. Gelati
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  3. B. Pollo
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  4. C. Marras
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  5. A. Silvani
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  6. M. R. Balestrini
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  7. M. Eoli
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  9. G. Broggi
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  10. A. Boiardi
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Correspondence to A. Salmaggi.

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Salmaggi, A., Gelati, M., Pollo, B. et al. CXCL12 Expression is Predictive of a Shorter Time to Tumor Progression in Low-Grade Glioma: A Single-Institution Study in 50 Patients. J Neurooncol 74, 287–293 (2005). https://doi.org/10.1007/s11060-004-7327-y

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  • DOI: https://doi.org/10.1007/s11060-004-7327-y

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