Abstract
Herein we describe the case of a patient with primary diffuse leptomeningeal gliomatosis (PDLG). After surgery and ventriculoperitoneal shunt placement, due to poor general conditions, the patient was not eligible for radiotherapy. For this reason we decided to start a systemic chemotherapy treatment with Temozolomide (150 mg/m2 per day for 5 days every 4 weeks). After three cycles a partial response was achieved with a clear improvement of general conditions. In our knowledge, this is the first time that PDLG treatment with Temozolomide has been described.
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EY Tsui K Loo CK Mok MK Yuen YK. Cheung (2001) ArticleTitlePrimary multifocal leptomeningeal gliomatosis Eur J Radiol 37 IssueID1 5–7 Occurrence Handle10.1016/S0720-048X(00)00220-5 Occurrence Handle1:STN:280:DC%2BD3MzjvVCkuw%3D%3D Occurrence Handle11274832
J Korein I Feigin MR. Shapiro (1957) ArticleTitleOligodendrogliomatosis with intracranial hypertension Neurology 7 589–594 Occurrence Handle1:STN:280:CyiD1MfmslQ%3D Occurrence Handle13451895
A Barborie EM Dunn LR Bridges JM. Bamford (2001) ArticleTitlePrimary diffuse leptomeningeal gliomatosis predominantly affecting the spinal cord: case report and review of the literature J Neurol Neurosurg Psychiatry 70 256–258 Occurrence Handle10.1136/jnnp.70.2.256 Occurrence Handle11160482
LA Corsten AI Raja FC Wagner SuffixJr. (2001) ArticleTitlePrimary diffuse leptomeningeal gliomatosis Br J Neurosurg 15 IssueID1 61–66
IS Cooper JW. Kemohan (1951) ArticleTitleHeterotopic glial nests in the subarachnoid space: histopathologic characteristics, mode of origin and relation to meningeal gliomas J Neuropathol Exp Neurol 10 16–29 Occurrence Handle1:STN:280:Cy6D3szmslA%3D Occurrence Handle14804124
S Kastenbauer A Danek W Klein et al. (2000) ArticleTitlePrimary diffuse leptomeningeal gliomatosis: unusual MRI with non-enhancing nodular lesions on the cerebellar surface and spinal leptomeningeal enhancement J Neurol Neurosurg Psychiatry 69 385–388 Occurrence Handle10.1136/jnnp.69.3.385 Occurrence Handle1:STN:280:DC%2BD3cvivFCgtA%3D%3D Occurrence Handle10945815
TF Witham MB Fukui CC Meltzer et al. (1999) ArticleTitleSurvival of patients with high grade glioma treated with intrathecal thiotriethylenephosphoramide for ependymal or leptomeningeal gliomatosis Cancer 86 1347–1353
P Beauchesne J Pilat P Duthel et al. (1998) ArticleTitleAggressive treatment with complete remission in primary diffuse leptomeningeal gliomatosis – a case report J Neurooncol 37 161–167 Occurrence Handle10.1023/A:1005888319228 Occurrence Handle1:STN:280:DyaK1c7ot1aksg%3D%3D Occurrence Handle9524095
WK Yung MD Prados R Yaya-Tur et al. (1999) ArticleTitleMulticenter phase II trial of temozolomide in patients with anaplastic astrocytoma or anaplastic oligoastrocytoma at first relapse J Clin Oncol 17 2762–2771 Occurrence Handle1:CAS:528:DyaK1MXmtlWru7s%3D Occurrence Handle10561351
WK Yung RE Albright J Olson et al. (2000) ArticleTitleA phase II study of temozolomide vs. procarbazine in patients with glioblastoma multiforme at first relapse Br J Cancer 83 588–593 Occurrence Handle1:CAS:528:DC%2BD3cXmvVCgsrs%3D Occurrence Handle10944597
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Franceschi, E., Cavallo, G., Scopece, L. et al. Temozolomide-induced partial response in a patient with primary diffuse leptomeningeal gliomatosis. J Neurooncol 73, 261–264 (2005). https://doi.org/10.1007/s11060-004-5672-5
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DOI: https://doi.org/10.1007/s11060-004-5672-5