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Electroencephalogram Coherence and Peripheral Markers of Nervous Tissue Damage in Depressive Disorders

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Objectives. To assess electroencephalogram coherence parameters and the levels of peripheral markers of nerve tissue damage in patients with depressive disorders. Materials and methods. The study included 30 patients with diagnoses from the mood disorders cluster: affective disorder as a single depressive episode and recurrent depressive disorder. The control group consisted of 30 healthy subjects of comparable sex and age composition. Brain bioelectrical activity was recorded and analyzed with calculation of mean intra- and interhemisphere coherence coefficients. Serum calcium-binding protein S100b, myelin basic protein (MBP), and glial fibrillary acidic protein (GFAP) concentrations were determined by enzyme-linked immunosorbent assay. Results. Patients with depressive disorders showed statistically significantly lower coefficients of interhemisphere coherence in the α (p = 0.003), β (p = 0.042), and θ (p = 0.041) rhythms and intrahemisphere coherence of the α rhythm in the left (p = 0.016) and right (p = 0.026) hemispheres and β rhythm in the right hemisphere (p = 0.034), as compared with the healthy group. Higher MBP concentrations were found in the depressive disorders group than the control group (p = 0.008). Statistically significant correlations were identified between EEG coherence coefficients and serum markers in patients with depressive disorders. Conclusions. These data clearly confirm the presence of inflammatory changes in the brain in patients with depression, which is reflected in structural and functional changes.

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Authors and Affiliations

  1. Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia

    S. A. Galkin, L. A. Levchuk, G. G. Simutkin, S. A. Ivanova & N. A. Bokhan

  2. Siberian State Medical University, Russian Ministry of Heath, Tomsk, Russia

    S. A. Ivanova & N. A. Bokhan

Authors
  1. S. A. Galkin
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  2. L. A. Levchuk
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  3. G. G. Simutkin
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  4. S. A. Ivanova
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  5. N. A. Bokhan
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Correspondence to S. A. Galkin.

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Translated from Zhurnal Nevrologii i Psikhiatrii imeni S. S. Korsakova, Vol. 123, No. 3, pp. 82–87, March, 2023.

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Galkin, S.A., Levchuk, L.A., Simutkin, G.G. et al. Electroencephalogram Coherence and Peripheral Markers of Nervous Tissue Damage in Depressive Disorders. Neurosci Behav Physi 53, 1355–1359 (2023). https://doi.org/10.1007/s11055-023-01525-2

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  • DOI: https://doi.org/10.1007/s11055-023-01525-2

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