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Association of Gene Polymorphisms DRD3 rs6280, COMT rs4680, and HTR2A rs7322347 with Schizophrenia

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Objectives. To seek associations of the genetic polymorphisms rs6280 of the DRD3 gene, rs4680 of the COMT gene, and rs7322347 of the HTR2A gene with schizophrenia. Materials and methods. The cohort included 300 inpatients with paranoid schizophrenia. The healthy control group consisted of 290 subjects. Associations between polymorphisms and study groups were assessed by logistic regression. Results. The severity of positive symptoms on the PANSS in the patient cohort was 14.0 [11.0; 18.0] points, the severity of negative symptoms was 21.0 [17.0; 27.0] points, and severity of other symptoms was 33.0 [27.8; 38.0] points. A between-group difference (p = 0.012) was found on comparison of the genotype for the rs7322347 polymorphism. The CC genotype of the rs6280 polymorphism was found to be associated with schizophrenia (OR 3.37 (1.50; 8.03)). The TT genotype of the rs7322347 polymorphism was associated with the control group (OR 1.83 (1.25; 2.68)). Conclusions. The analysis results confirmed the hypothesis that the genetic polymorphisms rs7322347 of the HTR2A gene (p = 0.006) and rs6280 of the DRD3 gene (p = 0.004) are associated with the disease. The hypothesis that there is a link between the rs4680 polymorphism of the COMT gene could not be confirmed.

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Authors and Affiliations

  1. Mechnikov Northwestern State Medical University, Russian Ministry of Health, St. Petersburg, Russia

    A. G. Sofronov, A. E. Dobrovolskaya, S. A. Kolchev & A. N. Gvozdetckii

  2. Skvortsov-Stepanov City Psychiatric Hospital No. 3, St. Petersburg, Russia

    A. G. Sofronov, A. E. Dobrovolskaya, E. A. Gorina, S. A. Kolchev & A. N. Gvozdetckii

  3. Serbsky National Medical Research for Psychiatry and Narcology, Russian Ministry of Health, Moscow, Russia

    A. Yu. Morozova

  4. Alekseev Psychiatric Clinical Hospital No. 1, Moscow City Health Department, Moscow, Russia

    A. Yu. Morozova

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  1. A. G. Sofronov
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  3. A. Yu. Morozova
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Correspondence to A. G. Sofronov.

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Translated from Zhurnal Nevrologii i Psikhiatrii imeni S. S. Korsakova, Vol. 122, No. 7, pp. 115–120, July, 2022.

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Sofronov, A.G., Dobrovolskaya, A.E., Morozova, A.Y. et al. Association of Gene Polymorphisms DRD3 rs6280, COMT rs4680, and HTR2A rs7322347 with Schizophrenia. Neurosci Behav Physi 53, 313–318 (2023). https://doi.org/10.1007/s11055-023-01427-3

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