Learning and behavior were more sensitive than LTP-like plasticity to blockade of NMDA receptors (NMDAr). I.p. and intraventricular injections of low, non-toxic doses of the non-competitive NMDAr antagonist MK-801 did not block LTP in the hippocampus but impaired hippocampus-dependent forms of learning and spatial behavior in both allo- and egocentric coordinate systems and prevented the reproduction of previously developed reactions in well-trained animals. Our results do not support the notion that there is an association between LTP-like plasticity and spatial learning.
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Translated from Zhurnal Vysshei Nervnoi Deyatel’nosti imeni I. P. Pavlova, Vol. 72, No. 3, pp. 405–420, May–June, 2022.
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Korshunov, V.A., Uzakov, S.S. Hippocampus-Dependent Learning Deficit Does Not Correlate with Suppression of Long-Term Post-Tetanic Potentiation by Systemic Blockade of NMDA Receptors. Neurosci Behav Physi 52, 1461–1471 (2022). https://doi.org/10.1007/s11055-023-01377-w
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DOI: https://doi.org/10.1007/s11055-023-01377-w