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Mechanisms of Apoptosis in Drug-Resistant Epilepsy

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Epilepsy is a chronic neurological disease with regular spontaneous seizures associated with neuroinflammatory, autoimmune, and neurodegenerative processes. Approximately 40% of patients have drug-resistant forms of epilepsy, increasing the risk of premature death, injury, irreversible brain damage, psychosocial dysfunction, and reduced quality of life. Apoptosis of neurons and glial cells in the brain is of great importance in the pathogenesis of epilepsy, especially the drug-resistant forms. Studies of the mechanisms of apoptosis are required for creation of new-generation neuroprotective and anticonvulsant drugs which will also be effective in drug-resistant epilepsy. The aim of the present work was to analyze the mechanisms and role of apoptosis in epileptogenesis and the formation of resistance. This review addresses current data on the main mechanisms of apoptosis operating in epilepsy, especially its drug-resistant forms.

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Authors and Affiliations

  1. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia

    E. D. Bazhanova & A. A. Kozlov

  2. Golikov Research Center of Toxicology, St. Petersburg, Russia

    E. D. Bazhanova

  3. Astrakhan State University, Astrakhan, Russia

    E. D. Bazhanova

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  1. E. D. Bazhanova
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  2. A. A. Kozlov
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Correspondence to E. D. Bazhanova.

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Translated from Zhurnal Nevrologii i Psikhiatrii imeni S. S. Korsakova, Vol. 122, No. 5, Iss. 1, pp. 43–50, May, 2022.

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Bazhanova, E.D., Kozlov, A.A. Mechanisms of Apoptosis in Drug-Resistant Epilepsy. Neurosci Behav Physi 52, 1360–1367 (2022). https://doi.org/10.1007/s11055-023-01367-y

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  • DOI: https://doi.org/10.1007/s11055-023-01367-y

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