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Changes in Psychoemotional State in Response to Neuroactive Amino Acid Derivatives in Rats After Chronic Alcohol Intoxication

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Objectives. To study the effects of neuroactive amino acid derivatives glufimet and mefargin on the psychoemotional state of rats after chronic alcohol intoxication (CAI). Materials and methods. Studies were carried out on 10-month-old female Wistar rats with a model of CAI produced by replacing drinking water with 10% ethyl alcohol solution sweetened with sucrose (50 g/liter) for six months. At the end of alcoholization, the animals (age 16 months) were divided into groups: group 1 (n = 15) was the intact group, i.e., rats without CAI; group 2 (n = 14) were controls, i.e., females after CAI; groups 3 (n = 11), 4 (n = 14), 5 (n = 11), and 6 (n = 10) were females which after developing CAI were treated with GABA derivative mefargin (25 mg/kg), glutamic acid derivative glufimet (29 mg/kg), or reference agents phenotropil (25 mg/kg) or heptral (100 mg/kg), respectively. Substances were administered to rats after six months of alcoholization i.p. once a day for 14 days; the intact and control groups received saline. The psychoemotional state of the animals was assessed after treatment using the open field, elevated plus maze, marble-burying, and Porsolt forced swimming tests. Results. Animals of the control group displayed increased anxiety, as evidenced by the greater number of boluses in the open field test compared with the intact group (p < 0.05) (3.43 ± ± 0.56 vs. 1.47 ± 0.39), shorter durations of stays in the open arms (26.07 ± 3.47 versus 68.67 ± 10.08), and fewer hangings from them (3.07 ± 0.25 versus 6.67 ± 0.79) in the elevated plus maze test. Rats buried more marbles after CAI (8.79 ± 1.15 versus 2.73 ± 0.71, p < 0.05), indicating compulsive behavior. In addition, control females had a depressed state, as evidenced by a long period of immobility in the Porsolt forced swimming test (2.36 ± 0.41 versus 0.87 ± 0.31, p < 0.05). Conclusions. Mefargin, glufimet, phenotropil, and heptral contributed to limiting anxiety and signs of obsessive-compulsive disorder in females exposed to alcohol (p < 0.05). An antidepressant effect was seen in animals treated with phenotropil and heptral after CAI (p < 0.05).

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Authors and Affiliations

  1. Volgograd State Medical University, Russian Ministry of Heath, Volgograd, Russia

    L. E. Borodkina, Yu.A. Smolnyakova, E. A. Muzyko & I. N. Tyurenkov

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  1. L. E. Borodkina
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  2. Yu.A. Smolnyakova
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  3. E. A. Muzyko
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  4. I. N. Tyurenkov
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Correspondence to E. A. Muzyko.

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Translated from Zhurnal Nevrologii i Psikhiatrii imeni S. S. Korsakova, Vol. 122, No. 4, Iss. 1, pp. 112–116, April, 2022.

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Borodkina, L.E., Smolnyakova, Y., Muzyko, E.A. et al. Changes in Psychoemotional State in Response to Neuroactive Amino Acid Derivatives in Rats After Chronic Alcohol Intoxication. Neurosci Behav Physi 52, 1195–1198 (2022). https://doi.org/10.1007/s11055-023-01347-2

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