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The Structural Basis of Epileptogenesis in an Adult Patient: Experience of Complex Diagnosis

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Diagnosis of the structural basis of focal epilepsy in an adult patient was used as an example for considering the potential of the multimodal and interdisciplinary approach to diagnosis, combining state-of-the-art neuroimaging methods with results from neurophysiological investigations. Interactions between highly trained specialists in epileptology, neuroradiology, and pathomorphology have a high probability of establishing the cause of the development of focal types of epilepsy. Along with the appearance of superinductive MRI systems, the correct use of their capabilities and optimization of scanning protocols to the characteristics of individual patients play an important role. The long-term treatment of drug-resistant focal epilepsy, especially on the background of low quality of life, progression of neurological deficit, and aggravation of cognitive and personality problems in patients, make it clear that these patients with uncontrolled seizures receiving antiepileptic drugs at inadequate doses for long periods of time, even with negative results from standard MRI scans, are candidates for deeper complex investigations with the aim of identifying the structural basis of epileptogenesis and subsequent epileptic surgery. Prompt complex diagnosis suggests new and rational antiepileptic treatment regimes, with improvements in patient compliance.

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Authors and Affiliations

  1. Federal Research and Clinical Center for Children and Adolescents, Russian Federal Medical Biological Agency, Moscow, Russia

    V. S. Khalilov & N. A. Medvedeva

  2. Pirogov Russian National Research Medical University, Russian Ministry of Health, Moscow, Russia

    V. S. Khalilov, A. A. Kholin & N. N. Zavadenko

  3. Russian Pediatric Clinical Hospital, Pirogov Russian National Research Medical University, Russian Ministry of Health, Moscow, Russia

    A. A. Kholin

  4. Morozov Children’s City Clinical Hospital, Moscow Health Department, Moscow, Russia

    A. N. Kislyakov

  5. Federal Research and Clinical Center for Specialized Medical Care and Medical Technologies, Russian Federal Medical Biological Agency, Moscow, Russia

    B. R. Bakaeva

  6. Health Center 4, Riga, Latvia

    K. I. Panova

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  1. V. S. Khalilov
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  3. A. N. Kislyakov
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  4. B. R. Bakaeva
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Correspondence to V. S. Khalilov.

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Translated from Zhurnal Nevrologii i Psikhiatrii imeni S. S. Korsakova, Vol. 121, No. 6, Iss. 1, pp. 27–33, June, 2021.

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Khalilov, V.S., Kholin, A.A., Kislyakov, A.N. et al. The Structural Basis of Epileptogenesis in an Adult Patient: Experience of Complex Diagnosis. Neurosci Behav Physi 52, 362–367 (2022). https://doi.org/10.1007/s11055-022-01249-9

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  • DOI: https://doi.org/10.1007/s11055-022-01249-9

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