Age-related impairments to the ability to perceive, store, and use novel information are under intense study in a number of animal species and humans. Cognitive defi cit in normal and pathological aging may result from impairments to the regulation of the transcription, translation, reception, and signaling of brain-derived neurotrophic factor (BDNF), which is key molecule involved in learning and memory processes, which are important cognitive components with the greatest vulnerability in aging. This brief review addresses current concepts of the involvement of the BDNF system in forming cognitive status in the adult and aging brain. Some current pharmacological and non-medication-based approaches stimulating BDNF expression and/or acting on the corresponding signal cascades, which have been confi rmed in experimental models and which may be useful or are already used in cognitive geriatrics, are also discussed.
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Translated from Zhurnal Vysshei Nervnoi Deyatel’nosti imeni I. P. Pavlova, Vol. 71, No. 4, pp. 453–467, July–August, 2021.
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Semenov, D.G., Belyakov, A.V. BDNF and Senile Cognitive Decline. Neurosci Behav Physi 52, 287–296 (2022). https://doi.org/10.1007/s11055-022-01236-0
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DOI: https://doi.org/10.1007/s11055-022-01236-0