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Effects of Early Social Isolation on Locomotor Activity and Learning Ability in Adult WAG/Rij Rats

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WAG/Rij rats, which are genetically predisposed to absence epilepsy and are characterized by a depressive state, were used for studies of the effects of complete 3-h daily social isolation at different critical periods of postnatal ontogeny (days 2–8, 9–15, and 16–22 after birth) on behavior in adulthood. Isolation from day 2 to day 8 and from day 16 to day 22 of life was found to increase locomotor activity in the open arms of an elevated plus maze and the open field test. Animals subjected to isolation from day 9 to day 15 did not show any changes in locomotor activity as compared with animals of the control group, though they displayed elevated emotional reactivity. More animals subjected to isolation from day 9 of life acquired a two-way conditioned avoidance reflex.

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Correspondence to A. Yu. Shishelova.

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Translated from Zhurnal Vysshei Nervnoi Deyatel’nosti imeni I. P. Pavlova, Vol. 71 No. 3, pp. 359–369, May–June, 2021.

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Shishelova, A.Y., Raevsky, V.V. Effects of Early Social Isolation on Locomotor Activity and Learning Ability in Adult WAG/Rij Rats. Neurosci Behav Physi 52, 89–96 (2022).

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