Objectives. To study the relationship between measures of oxidative stress and clinical changes in patients with neurodegenerative parkinsonism and identify clinical and biological subtypes of the disease. Materials and methods. The study included 109 subjects, of whom 91 were patients with neurodegenerative parkinsonism (72 patients with Parkinson’s disease (PD), 10 with multisystem atrophy (MSA), nine with corticobasal degeneration; mean age 61.1 ± 7.2 years) and 18 were clinically healthy people, mean age 55.1 ± 9.2 years. Peripheral blood redox status in PD patients and healthy subjects was assessed by assay of indicators of oxidative stress. Biochemical indicators were determined in RBC and mononuclear blood cells. Glutathione reductase (GR) and myeloperoxidase (MPO) activities were assayed, along with reduced glutathione levels. Results and conclusions. Oxidative stress is a universal mechanism and is seen in many neurodegenerative diseases. Nonetheless, quite characteristic changes in redox balance could be detected, defining groups and correlating them with particular subtypes and courses of PD, providing an opportunity for differential diagnosis from atypical parkinsonism.
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Translated from Zhurnal Nevrologii i Psikhiatrii imeni S. S. Korsakova, Vol. 120, No. 12, Iss. 1, pp. 80–85, December, 2020.
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Khadzieva, K.I., Chernikova, I.V., Milyutina, N.P. et al. Clinical and Biochemical Heterogeneity of Parkinson’s Disease. Neurosci Behav Physi 51, 1073–1078 (2021). https://doi.org/10.1007/s11055-021-01167-2
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DOI: https://doi.org/10.1007/s11055-021-01167-2