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Immunochemical and Electromyographic Indicators for Assessment of Pain Status in Reflex Syndrome

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Objective. To run complex investigations of patients with chronic reflex syndrome (CRS). Materials and methods. A total of 136 patients (70 women and 66 men) with chronic reflex syndrome were investigated. Pain was assessed on a visual analog scale (VAS) and levels of natural antibodies (n-Ab) to opioid peptides (β-endorphin and orphanin) and biogenic amines (dopamine and serotonin) were determined; surface electromyograms (sEMG) of the erector spinae muscle were recorded at the L3–L4 level on both sides. Parameters were measured at the beginning (day 1), in the middle (day 10), and end (day 21) of treatment. Results. Significant reductions in pain intensity (by 63% in women and 71% in men) were accompanied by 10–25% decreases in muscle tension in terms of group sEMG amplitude and by 34–38% in terms of individual dynamics of sEMG amplitude. Levels of n-Ab to all endogenous pain regulators were initially mostly elevated or high. Changes in n-Ab levels were in different directions. By the end of treatment (day 21), there were increases in the frequency of high levels of n-Ab to opioid peptides (39–41% of women and 33–39% of men) and normal levels of n-Ab to serotonin (in 52% of women and 59% of men). Levels of n-Ab to dopamine in women on day 21 were mainly normal (56% of subjects), while in men they were mostly elevated (in 50%) or high (in 17%). Conclusions. Changes in immunological measures did not correlate with pain intensity and evidently reflected pathological changes in neurohumoral interactions in chronic pain. Thus, monitoring of individual endogenous pain regulator n-Ab profiles in patients may have predictive value in assessing the further process of chronicization of pain status.

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Authors and Affiliations

  1. Institute of Physiologically Active Substances, Russian Academy of Sciences, Chernogolovka, Moscow District, Russia

    A. I. Levashova & M. A. Myagkova

  2. Russian Medical Academy for Continuous Professional Education, Russian Ministry of Health, Moscow, Russia

    I. A. Moseikin

Authors
  1. A. I. Levashova
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  2. M. A. Myagkova
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  3. I. A. Moseikin
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Correspondence to A. I. Levashova.

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Translated from Zhurnal Nevrologii i Psikhiatrii imeni S. S. Korsakova, Vol. 120, No. 12, Iss. 1, pp. 73–79, December, 2020.

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Levashova, A.I., Myagkova, M.A. & Moseikin, I.A. Immunochemical and Electromyographic Indicators for Assessment of Pain Status in Reflex Syndrome. Neurosci Behav Physi 51, 1066–1072 (2021). https://doi.org/10.1007/s11055-021-01166-3

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