Features of Cognitive Impairments in Patients with Comorbid Recurrent Affective and Panic Disorders

Objectives. To identify targets for medication and psychotherapy in the treatment of patients with comorbid recurrent affective and panic disorders based on results from studies of cognitive functions. Materials and methods. A set of pathopsychological methods (Schulte tables, correction test, 120-word test, cube drawing test, Binet and Berstein tests) was used. Cognitive status was studied in 60 patients with signs of recurrent affective (depressive) and panic disorders. ICD-10 diagnoses for the 27 patients making up the study group (SG) were recurrent affective disorder with mild and moderate depressive episodes (RAD, F33.0, F33.1) in combination with panic disorder (PD, F41.0). The control group (CG) included 33 patients with recurrent affective disorder (RAR, F33.0, F33.1) without panic disorder. Results and conclusions. All patients showed changes in the cognitive domain. Cognitive disorders in patients of the SG were more severe than those in patients of the CG. Cognitive functions in SG patients were characterized by being “left-hemisphere” impairments, in the form of paroxysmal emotional disorders with a predominance of fear and anxiety and dysfunction in the operation of a number of neuropsychological factors: successiveness, spatiality, inertia-mobility, for which the mediobasal and subcortical parts of the brain are responsible. Studies of cognitive impairments in remission provided evidence of some level of improvement in the cognitive domain in SG and CG patients, though there were no significant differences between the groups (p > 0.05). Targets for medication and psychotherapy in SG patients were attention, audioverbal memory, and components of thought (logical and spatial). The authors believe that use of neuropsychological correction of cognitive impairments is appropriate in patients of this group.

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Correspondence to I. A. Pastukh.

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Translated from Zhurnal Nevrologii i Psikhiatrii imeni S. S. Korsakova, Vol. 120, No. 7, Iss. 1, pp. 23–28, July, 2020.

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Tsygankov, B.D., Pastukh, I.A. Features of Cognitive Impairments in Patients with Comorbid Recurrent Affective and Panic Disorders. Neurosci Behav Physi 51, 283–288 (2021). https://doi.org/10.1007/s11055-021-01069-3

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Keywords

  • recurrent affective disorder
  • panic disorder
  • comorbidity
  • neuropsychological and pathopsychological study methods
  • cognitive processes