Objectives. To identify targets for medication and psychotherapy in the treatment of patients with comorbid recurrent affective and panic disorders based on results from studies of cognitive functions. Materials and methods. A set of pathopsychological methods (Schulte tables, correction test, 120-word test, cube drawing test, Binet and Berstein tests) was used. Cognitive status was studied in 60 patients with signs of recurrent affective (depressive) and panic disorders. ICD-10 diagnoses for the 27 patients making up the study group (SG) were recurrent affective disorder with mild and moderate depressive episodes (RAD, F33.0, F33.1) in combination with panic disorder (PD, F41.0). The control group (CG) included 33 patients with recurrent affective disorder (RAR, F33.0, F33.1) without panic disorder. Results and conclusions. All patients showed changes in the cognitive domain. Cognitive disorders in patients of the SG were more severe than those in patients of the CG. Cognitive functions in SG patients were characterized by being “left-hemisphere” impairments, in the form of paroxysmal emotional disorders with a predominance of fear and anxiety and dysfunction in the operation of a number of neuropsychological factors: successiveness, spatiality, inertia-mobility, for which the mediobasal and subcortical parts of the brain are responsible. Studies of cognitive impairments in remission provided evidence of some level of improvement in the cognitive domain in SG and CG patients, though there were no significant differences between the groups (p > 0.05). Targets for medication and psychotherapy in SG patients were attention, audioverbal memory, and components of thought (logical and spatial). The authors believe that use of neuropsychological correction of cognitive impairments is appropriate in patients of this group.
This is a preview of subscription content, access via your institution.
Buy single article
Instant access to the full article PDF.
Tax calculation will be finalised during checkout.
Subscribe to journal
Immediate online access to all issues from 2019. Subscription will auto renew annually.
Tax calculation will be finalised during checkout.
R. M. A. Hirschfeld, “The comorbidity of major depression and anxiety disorders: Recognition and management in primary care,” J. Clin. Psychiatry, 3, No. 6, 244–254 (2001), https://doi.org/10.4088/pcc.v03n0609.
N. Yu. Rakitskaya, “The evolution of diagnostic and therapeutic approaches to anxiety and depressive disorders,” Sib. Vestn. Psikhiatr. Narkol., 3, No. 54, 88–92 (2009).
A. A. Gorbunova and E. V. Kolyutskaya, “Panic disorder and affective pathology (comorbidity aspects,” Zh. Nevrol. Psikhiatr., 114, No. 10, 9–13 (2014).
E. A. Korabel’nikova, “A modern approach to the diagnosis and therapy of panic disorder,” Poliklin. Revmatol. Nevrol., Spec. Iss., 2, 31–36 (2016).
I. A. Pogosova, “Clinical features of panic disorders combined with comorbid mental and narcological pathology,” Nevrol. Vestn. Zh. im. Bekhtereva, 3, 42–47 (2012).
M. R. Restivo, M. C. McKinnon, B. N. Frey, et al., “Effect of obesity on cognition in adults with and without a mood disorder: study design and methods,” BMJ Open, 6, No. 2 (2016), https://doi.org/10.1136/bmjopen-2015-009347.
G. I. Papakostas and L. Culpepper, “Understanding and managing cognition in the depressed patient,” J. Clin. Psychiatry, 76, No. 4, 418–425 (2015), https://doi.org/10.4088/JCP.13086ah1c.
A. A. Chepelyuk, M. G. Vinogradova, T. V. Kovalenok, et al., “Cognitive processes in patients with different structure of anxiety disorders,” Zh. Nevrol. Psikhiatr., 118, No. 3, 4–9 (2018).
S. A. Gordeev, S. I. Posokhov, G. V. Kovrov, and S. V. Katenko, “Psychophysiological features of panic and generalized anxiety disorders,” Zh. Nevrol. Psikhiatr., 113, No. 5, 11–14 (2013).
M. G. Yanushko, M. V. Shamanina, and M. V. Ivanov, “Cognitive functioning parameters in patients with recurrent depressive disorder,” Sotsial. Klin. Psikhiatr., 27, No. 3, 27–31 (2017).
D. M. Tsarenko, “Clinical and psychopathological features of cognitive impairment in anxiety-depressive spectrum disorders,” Mosk. Nauchn. Issled. Inst. Psikhiatrii, 5, 3–19 (2012).
V. Ya. Semke and I. A. Pogosova, “Psychotherapy of comorbid phobic-anxiety and affective disorders,” Sib. Vestn. Psikhiatr. Narkol., 5, No. 62, 50–75 (2010).
B. D. Tsygankov and A. V. Yaltonskaya, . “Group cognitive-behavioral psychotherapy in the treatment of depressive disorders,” Zh. Nevrol. Psikhiatr., 112, No. 10, 68–74 (2012).
Translated from Zhurnal Nevrologii i Psikhiatrii imeni S. S. Korsakova, Vol. 120, No. 7, Iss. 1, pp. 23–28, July, 2020.
About this article
Cite this article
Tsygankov, B.D., Pastukh, I.A. Features of Cognitive Impairments in Patients with Comorbid Recurrent Affective and Panic Disorders. Neurosci Behav Physi 51, 283–288 (2021). https://doi.org/10.1007/s11055-021-01069-3
- recurrent affective disorder
- panic disorder
- neuropsychological and pathopsychological study methods
- cognitive processes