Characteristics of the Behavioral Phenotype of BALB/C Mice

The existence of specific behavioral characteristics which can be regarded as autistic spectrum disorder (ASD) in BALB/c mice was detected and confirmed, these consisting of a low level of interaction with socially relevant stimuli and even avoidance of this interaction, along with impairment to the discrimination and particularly the recognition of odors, elevated anxiety, and stereotypical behavior. BALB/c mice provide an experimental model of idiopathic ASD for studies of the pathogenesis of the diseases and its phenotypic manifestations, as well as for evaluating potential substances for the correction of ASD.

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Correspondence to I. G. Kapitsa.

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Translated from Rossiiskii Fiziologicheskii Zhurnal imeni I. M. Sechenova, Vol. 106, No. 3, pp. 373–383, March, 2020.

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Kapitsa, I.G., Ivanova, E.A., Voronina, T.A. et al. Characteristics of the Behavioral Phenotype of BALB/C Mice. Neurosci Behav Physi 51, 93–99 (2021). https://doi.org/10.1007/s11055-020-01043-5

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Keywords

  • BALB/c mice
  • autistic spectrum disorders
  • social deficit
  • stereotypy
  • impaired olfaction
  • anxiety