Synchronized activity the hallmark of neural networks. Early sharp waves (eSPW) form one type of synchronized activity – these are synchronized network discharges of neuronal ensembles seen in the developing hippocampus. Despite the fact that eSPW may play a central role in coordinating neural activity and forming hippocampal functions, little is known of changes in eSPW during early postnatal development. Our experiments on neonatal rat pups using multichannel extracellular electrodes showed that during the first two weeks of postnatal life, along with reductions in the duration of eSPW, there were increases in their frequency and amplitude. We also found an increase in extracellular recorded activity of neurons in the pyramidal layer of the hippocampus. These data lead to the suggestion that the dynamics of changes in eSPW and overall network hippocampal activity are associated with the development of the hippocampal neural network and bottom-up neuromodulator projections.
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Ben-Ari, Y., “Developing networks play a similar melody,” Trends Neurosci., 24, No. 6, 353–360 (2001).
Ben-Ari, Y., Gaiarsa, J.-L., Tyzio, R., and Khazipov, R., “GABA: A pioneer transmitter that excites immature neurons and generates primitive oscillations,” Physiol. Rev., 87, No. 4, 1215–1284 (2007).
Buhl, D. L. and Buzsáki, G., “Developmental emergence of hippocampal fast-field ‘ripple’ oscillations in the behaving rat pups,” Neuroscience, 134, No. 4, 1423–1430 (2005).
Buzsáki, G., “Hippocampal sharp wave-ripple: A cognitive biomarker for episodic memory and planning,” Hippocampus, 25, No. 10, 1073–1188 (2015).
Buzsáki, G., Buhl, D. L., Harris, K. D., et al., “Hippocampal network patterns of activity in the mouse,” Neuroscience, 116, No. 1, 201–211 (2003).
Buzsáki, G., Horváth, Z., Urioste, R., et al., “High-frequency network oscillation in the hippocampus,” Science, 256, No. 5059, 1025–1027 (1992).
Chrobak, J. J. and Buzsáki, G., “High-frequency oscillations in the output networks of the hippocampal-entorhinal axis of the freely behaving rat,” J. Neurosci., 16, No. 9, 3056–3066 (1996).
Colonnese, M. T., Kaminska, A., Minlebaev, M., et al., “A conserved switch in sensory processing prepares developing neocortex for vision,” Neuron, 67, No. 3, 480–498 (2010).
Csicsvari, J., Hirase, H., Czurkó, A., et al., “Fast network oscillations in the hippocampal CA1 region of the behaving rat,” J. Neurosci., 19, No. 16, RC20 (1999).
Karlsson, K., Mohns, E. J., Viana di Prisco, G., and Blumberg, M. S., “On the co-occurrence of startles and hippocampal sharp waves in newborn rats,” Hippocampus, 16, No. 11, 959–965 (2006).
Karlsson, K. Æ. and Blumberg, M. S., “Hippocampal theta in the newborn rat is revealed under conditions that promote REM sleep,” J. Neurosci., 23, No. 4, 1114–1118 (2018).
Khazipov, R., Zaynutdinova, D., Ogievetsky, E., et al., “Atlas of the postnatal rat brain in stereotaxic coordinates,” Front. Neuroanat., 9, 161 (2015).
Laurent, F. F., Brotons-Mas, J. R., Cid, E., et al., “Proximodistal structure of theta coordination in the dorsal hippocampus of epileptic rats,” J. Neurosci., 35, No. 11, 4760–4775 (2015).
Lebovitz, R. M., Dichter, M., and Spencer, W. A., “Recurrent excitation in the CA3 region of cat hippocampus,” Int. J. Neurosci., 2, No. 2, 99–107 (1971).
Leinekugel, X., Khazipov, R., Cannon, R., et al., “Correlated Bursts of Activity in the Neonatal Hippocampus in Vivo,” Science, 296, No. 5575, 2049–2052 (2002).
MacVicar, B. A. and Dudek, F. E., “Local synaptic circuits in rat hippocampus: interactions between pyramidal cells,” Brain Res., 184, No. 1, 220–223 (1980).
Mohns, E. J. and Blumberg, M. S., “Synchronous bursts of neuronal activity in the developing hippocampus: modulation by active sleep and association with emerging gamma and theta rhythms,” J. Neurosci., 28, No. 40, 10,134–10,144 (2008).
Mohns, E. J., Karlsson, K., and Blumberg, M. S., “Developmental emergence of transient and persistent hippocampal events and oscillations and their association with infant seizure susceptibility,” Eur. J. Neurosci., 26, No. 10, 2719–2730 (2007).
Nicholson, C., Freeman, J. A., and Freeman, A., “Theory of current source-density analysis determination of conductivity tensor for anuran cerebellum,” J. Neurophysiol, 38, No. 2, 356 (1975).
Pesaran, B., Spectral Analysis for Neural Signals. Short Course III, 1 (2008).
Pokorný, J. and Yamamoto, T., “Postnatal ontogenesis of hippocampal CA1 area in rats. I. Development of dendritic arborisation in pyramidal neurons,” Brain Res. Bull., 7, No. 2, 113–120 (1981).
Rakic, P. and Riley, K. P., “Regulation of axon number in primate optic nerve by prenatal binocular competition,” Nature, 305, No. 5930, 135–137 (1983).
Spigelman, I., Zhang, L., and Carlen, P. L., “Patch-clamp study of postnatal development of CA1 neurons in rat hippocampal slices: Membrane excitability and K+ currents,” J. Neurophysiol, 68, No. 1, 55–69 (1992).
Spitzer, M. W., Calford, M. B., Clarey, J. C., et al., “Spontaneous and stimulus-evoked intrinsic optical signals in primary auditory cortex of the cat spontaneous and stimulus-evoked intrinsic optical signals in primary auditory cortex of the cat,” J. Neurophysiol., 85, 1283–1298 (2006).
Sullivan, D., Csicsvari, J., Mizuseki, K., et al., “Relationships between hippocampal sharp waves, ripples, and fast gamma oscillation: influence of dentate and entorhinal cortical activity,” J. Neurosci., 31, No. 23, 8605–8616 (2011).
Traub, R. D. and Bibbig, A., “A model of high-frequency ripples in the hippocampus based on synaptic coupling plus axon-axon gap junctions between pyramidal neurons,” J. Neurosci., 20, No. 6, 2086–2093 (2000).
Valeeva, G., Janackova, S., Nasretdinov, A., et al., “Emergence of coordinated activity in the developing entorhinal-hippocampal network,” Cereb. Cortex, 29, No. 2, 1–15 (2019).
Van der Loos, H. and Woolsey, T., “Somatosensory cortex: structural alterations following early injury to sense organs,” Science, 173, No. 4071, 395–398 (1973).
Woolsey, T. and Van der Loos, H., “The structural organization of layer IV in the somatosensory region (S I) of mouse cerebral cortex. The description of a cortical field composed of discrete cytoarchitectonic units,” Brain Res., 17, No. 2, 205–242 (1970).
Translated from Zhurnal Vysshei Nervnoi Deyatel’nosti imeni I. P. Pavlova, Vol. 70, No. 3, pp. 351–359, May–June, 2020.
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Shumkova, V.V., Sitdikova, V.R., Suchkov, D.S. et al. Developmental Changes in Early Sharp Waves in the Hippocampus of Neonatal Rats. Neurosci Behav Physi 51, 42–47 (2021). https://doi.org/10.1007/s11055-020-01037-3
- early activity rhythms
- neural network
- early sharp waves