Characteristics of Cognitive Impairments in Alcoholic and Dyscirculatory Encephalopathies

Objective. To identify the features of cognitive impairments (CI) in patients with alcoholic (AE) and dyscirculatory (DE) encephalopathies. Materials and methods. The study included 32 patients with DE and 30 with AE. Along with clinical observations, patients underwent computerized electroencephalography (EEG), recording of cognitive event-related potentials, and neuropsychological testing. Results and conclusions. The pathologies studied here showed both common and distinct signs in the clinical picture, in the emotional-personality domain, and impairments to cognitive processes. Common features of encephalopathies of different etiologies were CI and asthenic syndrome; AE was characterized by hyposthenic and DE by mixed (hyper- and hyposthenic) syndromes. The EEG showed that changes in bioelectrical activity in DE were predominantly located in the occipital-parietal areas of the cortex, while in AE they were located in the temporal and occipital-parietal areas. CI in DE and AE consisted of disorders to categorial thinking, long-term memory, reciprocal coordination, and digital gnosis, pointing to dysfunction of the frontal and parietal lobes of the left hemisphere, hippocampus, and corpus callosum. The indexes of the δ, β1, and β2 rhythms were discriminating features of CI in AE and DE.

This is a preview of subscription content, access via your institution.

References

  1. 1.

    L. A. Dobrynina and D. Yu. Lagoda, “Neurogenesis in the adult brain – a potential therapeutic target in degenerative diseases of the brain,” Medica Mente. Lechim s Umom, 4, No. 1, 16–19 (2018).

    Google Scholar 

  2. 2.

    M. A. Evzel’man and N. A. Aleksandrova, “Cognitive disorders in cerebrovascular diseases.,” Uch. Zap. Orlovsk. Gos. Univ. Ser. Estestv. Tekhn. Med. Nauki, 4, 77–79 (2009).

    Google Scholar 

  3. 3.

    V. A. Parfenov, S. A. Zhivolupov, V. V. Zakharov, et al., “Chronic cerebrovascular diseases: use of vinpocetin in neurological practice (round table discussion),” Nevrol. Neiropsikh. Psikhosom., 10, No. 4, 139–145 (2018).

    Google Scholar 

  4. 4.

    N. N. Usova, N. V. Galinovskaya, A. A. Levshenkova, and L. A. Lemeshkov, “Cognitive impairments in vascular brain diseases (literature review),” Prob. Zdorov. Ekol., 4, No. 42, 34–39 (2014).

    Google Scholar 

  5. 5.

    P. B. Gorelick, A. Scuteri, S. E. Black, et al., “Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the American Heart Association/American Stroke Association,” Stroke, 42, No. 9, 2672–2713 (2011), https://doi.org/10.1161/STR.0b013e3182299496.

    Article  PubMed  PubMed Central  Google Scholar 

  6. 6.

    I. M. Verjugina, I. M. Starovoitova, A. Sh. Chimagomedova, and O. S. Levin, “Endothelial dysfunction in chronic vascular encephalopathy,” Zh. Nevrol. Psikhiat., 117, No. 6, 73 (2017), https://doi.org/10.17116/jnevro20171176273-80.

    CAS  Article  Google Scholar 

  7. 7.

    G. C. Roman, T. Erkinjuntti, and A. Wallin, “Subcortical ischemic vascular dementia,” Lancet Neurol., 1, 426–436 (2002).

    Article  Google Scholar 

  8. 8.

    S. E. Black, “Vascular cognitive impairment: Epidemiology, subtypes, diagnosis and management,” J. Roy. Coll. Phys. Edinburgh, 41, 49–56 (2011), https://doi.org/10.4997/JRCPE.2011.121.

    CAS  Article  Google Scholar 

  9. 9.

    J. O’Brian, T. Erkinjuntti, B. Reisburg, et al., “Vascular cognitive impairment,” Lancet Neurol., 2, 89–98 (2003).

    Article  Google Scholar 

  10. 10.

    S. V. Shormanov, “The quite of the state of the brain in alcoholism and the pathogenesis of this disease,” Usp. Sovr. Estestvozn., 2, 41–43 (2011).

    Google Scholar 

  11. 11.

    Y. Alexandrov, Y. Grinchenko, D. Shevchenko, et al., “The Effect of ethanol on the neuronal subserving of behavior in the hippocampus,” J. Behav. Brain Sci., 3, No. 1, 107–130 (2013), https://doi.org/10.4236/jbbs.2013.31011.

    CAS  Article  Google Scholar 

  12. 12.

    H. Morikawa and R. A. Morrisett, “Ethanol action on dopaminergic neurons in the ventral tegmental area: interaction with intrinsic ion channels and neurotransmitter inputs,” Int. Rev. Neurobiol., 91, 235–288 (2010), https://doi.org/10.1016/S0074-7742(10)91008-8.

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  13. 13.

    J. M. Silvers, S. Tokunaga, R. B. Berry, et al., “Impairments in spatial learning and memory: ethanol, allopregnanolone, and the hippocampus,” Brain Res. Rev., 43, 275–284 (2003), https://doi.org/10.1016/j.brainresrev.2003.09.002.

    CAS  Article  PubMed  Google Scholar 

  14. 14.

    A. U. Tarkhan, G. A. Nezhdanov, A. A. Drozdov, et al., “Effects of the features of interhemisphere asymmetry of the brain and the type of cerebral deficiency on emotional disorders and alexithymia in alcohol dependence,” Obozr. Psikhiatr. Med. Psikhol., 4, 59–65 (2017).

    Google Scholar 

  15. 15.

    L. S. Manvelov and A. S. Kadykov, “Mild and moderate changes in cognitive functions in chronic vascular brain diseases,” Vrach, 7, 70–73 (2008).

    Google Scholar 

  16. 16.

    M. Yu. Moiseev, L. A. Belova, V. V. Mashin, et al., “Magnetic resonance tomography in the diagnosis of constitutive venous insufficiency in patients with hypertonic dyscirculatory encephalopathy,” Ul’yanovsk. Med. Biol. Zh., 2, 8–18 (2017), https://doi.org/10.23648/UMBJ.2017.26.6213.

  17. 17.

    E. V. Katamanova, O. I. Shevchenko, O. L. Lakhman, et al., “Impairments to higher mental functions in encephalopathies of different origins,” Acta Biomed. Scient., 1, 26–29 (2012).

  18. 18.

    E. V. Katamanova, O. I. Shevchenko, V. P. Kas’yanovskaya, et al., “Potentials of neurophysiological study methods in encephalopathies of work-related and non-work-related origins,” Acta Biomed. Scient., 3–2, No. 91, 17–21 (2013).

  19. 19.

    I. V. Podsonnaya and G. G. Efremushkin, “Neurophysiological markers for dyscirculatory encephalopathy in Chernobyl atomic power station clean-up workers,” Wschodnioeur. Czasopis. Nauk. (East Europ. Sci. J.), 6, No. 1, 113–117 (2016).

    Google Scholar 

  20. 20.

    A. U. Tarkhan, I. N. Baburin, D. O. Belogortsev, et al., “Neuropsychological studies in neurotic disorders: clinical-pathological and differential diagnostic aspects,” Vestn. Psikhoter., 42, 61–84 (2012).

    Google Scholar 

  21. 21.

    O. I. Shevchenko, E. V. Katamanova, V. S. Rukavishnikov, and O. L. Lakhman, “Cognitive impairments in toxic mercury and alcohol encephalopathies,” Med. Truda Prom. Ekol., 4, 19–26 (2015).

    Google Scholar 

  22. 22.

    Yu. V. Sturova, E. R. Barantsevich, O. V. Posokhina, and E. V. Verbitskaya, “Studies of neuropsychological status and quality of life in patients with dyscirculatory encephalopathy,” Nauch. Vestn. Zdravoohr. Kubani, 4, No. 34, 26–40 (2014).

    Google Scholar 

  23. 23.

    D. M. Bannerman, J. N. P. Rawlins, S. B. McHugh, et al., “Regional dissociations within the hippocampus-memory and anxiety,” Neurosci. Biobehav. Rev., 8, 273–283 (2004).

    Article  Google Scholar 

  24. 24.

    Yu. A. Aleksandrovskii (ed.), National Guidelines. Psychiatry, GEOTAR-Media, Moscow (2009).

  25. 25.

    I. I. Sholomov, O. V. Kolokova, A. S. Kruttsov, et al., Neurology, Saratov State Medical University Press, Saratov (2010).

    Google Scholar 

  26. 26.

    S. Ya. Rubinshtein, Experimental Methods in Pathophysiology and Experience in Their Use in Clinical Practice, G. P. Butenko (ed.), Institute of Psychotherapy Press, Moscow (2010).

  27. 27.

    I. F. Roshchina, S. I. Gavrilova, and Ya. B. Fedorova, “Neuropsychological structure and prognosis of mild cognitive deficit syndrome in the elderly,” Psikhiatriya, I. F. 2, 42–49 (2007).

  28. 28.

    B. Dubois, A. Slachevsky, I. Litvan, and B. Pillon, “The FAB: A Frontal Assessment Battery at bedside,” Neurology, 55, No. 11, 1621–1626 (2000).

    CAS  Article  Google Scholar 

  29. 29.

    M. F. Folstein, S. E. Folstein, and P. R. McHugh, “Mini-Mental State: a practical guide for grading the mental state of patients for the clinician,” J. Psychiatr. Res., 12, 189–198 (1975).

    CAS  Article  Google Scholar 

  30. 30.

    V. V. Gnezditskii, O. S. Korepina, A. V. Chatskaya, and O. I. Klochkova, “Memory, cognition, and endogenous event-related potentials of the brain: assessment of impairments to cognitive functions and the volume of operative memory without psychological testing,” Usp. Fiziol. Nauk., 48, No. 1, 3–23 (2017).

    Google Scholar 

  31. 31.

    O. I. Klochkova and V. V. Gnezditskii, “ Use of cognitive ERP (P300) for assessment of frequency of possible player memory accesses during computer interactions,” Fiziol. Cheloveka, 44, No. 1, 20–29 (2018).

    Google Scholar 

  32. 32.

    D. R. Shtul’man and O. S. Levin, Neurology: Textbook, Medpressinform, MX (2007).

  33. 33.

    J. N. Fogarty and M. Vogel-Sprott, “Cognitive processes and motor skills differ in sensitivity to alcohol impairment,” J. Stud. Alcohol Drugs, 63, No. 4, 404–411 (2002).

    Article  Google Scholar 

  34. 34.

    N. N. Kameneva, “Features of cognitive impairments in patients with ischemic stroke,” Priklad. Inform. Asp. Med., 21, No. 2, 45–50 (2018).

    Google Scholar 

  35. 35.

    D. S. Bassett and E. T. Bullmore, “Human brain networks in the field of health and disease,” Curr. Opin. Neurol., 22, 340–347 (2009).

    Article  Google Scholar 

  36. 36.

    R. Coras, F. A. Siebzehnrubl, E. Pauli, et al., “Low proliferation capacities of adult hippocampal stem cells correlate with memory dysfunction in humans,” Brain, 133, No. 11, 3359–3372 (2010), https://doi.org/10.1093/brain/awq303.

    Article  PubMed  Google Scholar 

  37. 37.

    V. A. Karlov, V. V. Gnezditskii, and S. V. Kudryavtseva, “Paroxysmal activity and impairments to the quality of autonomic regulation in the pathogenesis of paroxysmal states,” Akt. Vopr. Nevrol., 2, 2–6 (2010).

    Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to O. I. Shevchenko.

Additional information

Translated from Zhurnal Nevrologii i Psikhiatrii imeni S. S. Korsakova, Vol. 120, No. 5, Iss. 1, pp. 16–23, May, 2020.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Shevchenko, O.I., Lakhman, O.L. & Katamanova, E.V. Characteristics of Cognitive Impairments in Alcoholic and Dyscirculatory Encephalopathies. Neurosci Behav Physi 51, 36–41 (2021). https://doi.org/10.1007/s11055-020-01036-4

Download citation

Keywords

  • cognitive impairments
  • alcoholic encephalopathy
  • dyscirculatory encephalopathy
  • differential diagnosis