Efficacy of Metabolic Correction in the Early Recovery Period in Patients with Ischemic Stroke

Objective. To assess the efficacy of including the formulation Cytoflavin in rehabilitation programs for patients in the early recovery period of ischemic stroke. Materials and methods. The results of rehabilitation measures were assessed in 100 patients (50 women and 50 men aged 18–85 years) in the early recovery period of ischemic stroke. Neurological and psychological investigations included the NIHSS, MMSE, and Rankin scales, the Rivermead mobility index, and a physical exercise tolerance test. Depending on the rehabilitation scheme, patients were divided into two groups. The study group included 50 patients receiving courses of verticalization and i.v. dropwise Cytoflavin infusions (20.0 ml in 250ml 5% glucose) for 14 days. The reference group consisted of 50 patients who received standard rehabilitation courses. Results and conclusions. Inclusion of Cytoflavin in the rehabilitation programs of patients with ischemic stroke increased treatment efficacy, which was apparent as decreases in the severity of neurological impairments (on the NIHSS) by 17.6% in the study group vs. 10.8% in the reference group (p < 0.05) and recovery of cognitive functions (on the MMSE) by 5.8% vs. 1.6% in the reference group (p < 0.05). In addition, there was an improvement in the recovery of arterial blood pressure, by 37.1% in the study group vs. 30.6% in the reference group (p < 0.05).

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Correspondence to T. S. Poltavskaya.

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Translated from Zhurnal Nevrologii i Psikhiatrii imeni S. S. Korsakova, Vol. 120, No. 3, Iss. 2, Stroke, pp. 49–53, March, 2020.

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Poltavskaya, T.S., Bazhenov, V.A. & Volojanin, A.V. Efficacy of Metabolic Correction in the Early Recovery Period in Patients with Ischemic Stroke. Neurosci Behav Physi 51, 12–15 (2021). https://doi.org/10.1007/s11055-020-01032-8

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Keywords

  • rehabilitation
  • early recovery period
  • ischemic stroke
  • verticalization
  • metabolic therapy
  • Cytoflavin