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Neuromorphological Aspects of the GABAergic Hypothesis of the Pathogenesis of Schizophrenia

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The scientific literature contains several hypotheses for the pathogenesis of schizophrenia. The most widespread hypotheses for schizophrenia are the dopaminergic, serotoninergic, and glutamatergic hypotheses. There is also the suggestion that other neurochemical systems are involved in the pathogenesis of schizophrenia, particularly the GABAergic. This review considers published data on derangements of GABAergic interneurons in schizophrenia, taking account of data on post-mortem, neuroimaging, molecular-genetic, and electrophysiological research. A hypothesis for the pathogenesis of schizophrenia based on impairments to the myelination of GABAergic interneurons is proposed, these impairments leading to decreases in the numbers of intra- and interhemisphere coherent connections and the appearance of symptoms of the disease.

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  1. Mental Health Science Center, Moscow, Russia

    V. M. Vostrikov

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V. M. Vostrikov is deceased

Translated from Zhurnal Nevrologii i Psikhiatrii imeni S. S. Korsakova, Vol. 119, No. 8, Iss. 1, pp. 124–129, August, 2019.

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Vostrikov, V.M. Neuromorphological Aspects of the GABAergic Hypothesis of the Pathogenesis of Schizophrenia. Neurosci Behav Physi 50, 663–668 (2020). https://doi.org/10.1007/s11055-020-00952-9

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