This review provides the first summary of the literature from the last decade characterizing the cytoarchitectonics, neuronal organization, and electron microscopic characteristics of neurons in the medial nucleus (MN) of the amygdala (A) of the telencephalon and the representation within it of neurotransmitter systems. Data are presented evidencing the involvement of the MN in functional processes linked with instinctive behavior – feeding, aggressive-defensive, and reproductive – whose realization is mediated by the hypothalamus. Data on the genoarchitectonics of this nucleus show that the MN is formed as a derivative of subpallial (anterior geniculate area), pallial (ventral pallium), and extratelencephalic (preoptic area) progenitor domains. The multiplicity and diversity of histogenetic domains involved in forming the MN provide evidence of complex multistage occurring in the A during evolutionary processes.
Similar content being viewed by others
References
A. V. Akhmadeev, “The organizing influence of androgen on neurons in the posterior medial nucleus of the amygdaloid complex of the rat brain,” Ontogenez, 39, No. 5, 374–378 (2008).
A. V. Akhmadeev, “Experimental approaches to studies of the role of genotype at the Taq 1A locus of the dopamine D2 receptor in drug dependence,” Ros. Fiziol. Zh., 96, No. 5, 513–520 (2010).
A. V. Akhmadeev and L. B. Kalimullina, “Measures of the modulatory influence of sex steroids on the ultrastructural characteristics of neurons in the dorsomedial nucleus of the amygdaloid complex of the brain,” Tsitologiya, 48, No. 12, 971–979 (2006).
A. V. Akhmadeev and L. B. Kalimullina, “Neuroendocrine reproductive centers in the corticomedial segment of the amygdaloid complex of the brain,” Ros. Fiziol. Zh., 101, No. 5, 497–514 (2015).
A. V. Akhmadeev and L. B. Kalimullina, “The amygdaloid complex of the brain in the mechanisms of alcohol dependence,” Usp. Fiziol. Nauk., 47, No. 2, 27–44 (2016).
A. V. Akhmadeev and L. B. Kalimullina, “What is the amygdaloid complex of the brain?” Usp. Fiziol. Nauk., 48, No. 3, 56–71 (2017).
D. A. Adekunbi, X. F. Li, G. Lass, et al., “Kisspeptin neurons in the posterodorsal medial amygdala modulate sexual partner preference and anxiety in male mice,” J. Neuroendocrinol., 30, No. 3 (2018), doi: https://doi.org/10.1111/jne.12572.
X. Bian, “Physiological and morphological characterization of GABAergic neurons in the medial amygdala,” Brain Res., 1509, 8–19 (2013), doi: https://doi.org/10.1016/j.brainres.2013.03.012.
X. Bian, Y. Yanagawa, W. R. Chen, and M. Luo, “Cortical-like functional organization of the pheromone-processing circuits in the medial amygdala,” J. Neurophysiol., 99, No. 1, 77–86 (2008).
L. L. Bruce, “The puzzle of forebrain evolution,” Brain Behav., 79, No. 3, 141–143 (2012), doi: https://doi.org/10.1159/000335343.
A. Dall’Oglio, A. C. Dutra, J. E. Moreira, and A. A. Rasia-Filho, “The human medial amygdala: structure, diversity, and complexity of dendritic spines,” J. Anat, 227, No. 4, 440–459 (2015), doi: https://doi.org/10.1111/joa.12358.
E. A. Fortaleza, N. C. Ferreira-Junior, D. C. Lagatta, et al., “The medial amygdaloid nucleus modulates the baroreflex activity in conscious rats,” Auton. Neurosci., 193, 44–50 (2015), doi: https://doi.org/10.1016/j.autneu.2015.07.003.
M. García-López, A. Abellán, I. Legaz, et al., “Histogenetic compartments of the mouse centromedial and extended amygdala based on gene expression patterns during development,” J. Comp. Neurol., 506, No. 1, 46–74 (2008), doi: https://doi.org/10.1002/cne.21524.
S. Guirado, M. A. Real, and J. C. Davila, “Distinct immunohistochemically defined areas in the medial amygdala in the developing and adult mouse,” Brain Res. Bull., 75, No. 2–4, 214–217 (2008), doi: https://doi.org/10.1016/j.brainresbull.2007.10.016.
J. Haller, “The role of central and medial amygdale in normal and abnormal aggression. A review of classical approaches,” Neurosci. Biobehav. Rev., 85, 34–43 (2018), doi: https://doi.org/10.1016/j.neubiorev.2017.09.017.
M. H. Hu, Z. Bashir, X. F. Li, and K. T. O’Byrne, “Posterodorsal medial amygdala mediates Tail-Pench induced food intake in female rats,” J. Neuroendocrinol., 28, No. 5 (2016), doi: https://doi.org/10.1111/jne.12390.
L. B. Kalimullina, Kh. A. Kalkamanov, A. V. Akhmadeev, et al., “Structural bases for neurophysiological investigations of amygdaloid complex of the brain,” Sci. Rep., 5, Art. No. 17052 (2015), doi:https://doi.org/10.1038/srep17052.
S. Keshavarzi, R. K. Sullivan, D. J. Ianno, and P. Sah, “Functional properties and projections of neurons in the medial amygdale,” J. Neurosci., 34, No. 26, 8699–8715 (2014), doi: https://doi.org/10.1523/JNEUROSCI.1176-14.2014.
Y. Mohamadi, S. B. Jameie, M. Akbari, et al., “Hyperglycemia decreased medial amygdale projections to medial preoptic area in experimental model of Diabetes Mellitus,” Acta Med. Iran, 53, No. 1, 1–7 (2015).
A. Nagalski, L. Puelles, M. Dabrowski, et al., “Molecular anatomy of the thalamic complex and the underiying transcription factors,” Brain Struct. Funct., 221, No. 5, 2493–2510 (2016), doi: https://doi.org/10.1007/s00429-015-1052-5.
C. Pardo-Bellver, B. Cádiz-Moretti, A. Novejarque, et al., “Differential efferent projections of the anterior, posteroventral, and posterodorsal subdivisions of the medial amygdala in mice,” Front. Neuroanat., 6, No. 33 (2012), doi: https://doi.org/10.3389/fnana.2012.00033.
S. Parnaudeau, P. K. O’Neill, S. S. Bolkan, et al., “Inhibition of mediodorsal thalamus disrupts thalamofrontal connectivity and cognition,” Neuron, 77, No. 6, 1151–1162 (2013), doi: https://doi.org/10.1016/j.neuron.2013.01.038.
A. Petrulis, “Chemosignals, hormones and mammalian reproduction,” Horm. Behav., 63, No. 5, 723–741 (2013), doi: https://doi.org/10.1016/j.yhbeh.2013.03.011.
T. Shimogori, D. A. Lee, A. Miranda-Angulo, et al., “A genomic atlas of mouse hypothalamic development,” Nat. Neurosci., 13, No. 6, 767–775 (2010), doi: https://doi.org/10.1038/nn.2545.
E. Quagliotto, K. R. Casali, P. Dal Lago, and A. A. Rasia-Filho, “Neuropeprides in the posterodorsal medial amygdala modulate central cardiovascular reflex responses in awake male rats,” Braz. J. Med. Biol. Res., 48, No. 2, 128–139 (2015), doi: https://doi.org/10.1590/1414-431X20144095.
M. Zancan, A. Dall’Oglio, E. Quagliotto, and A. A. Rasia-Filho, “Castration alters the number and structure of dendritic spines in the male posterodorsal medial amygdala,” Eur. J. Neurosci., 45, No. 4, 572–580 (2017), doi: https://doi.org/10.1111/ejn.13460.
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Morfologiya, Vol. 156, No. 4, pp. 106–110, July–August, 2019.
Rights and permissions
About this article
Cite this article
Akhmadeev, A.V., Yangurazova, Z.A., Tel’tsova, L.Z. et al. Structural-Functional Organization and Genoarchitectonics of the Medial Amygdaloid Nucleus of the Telencephalon. Neurosci Behav Physi 50, 658–661 (2020). https://doi.org/10.1007/s11055-020-00950-x
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11055-020-00950-x