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Compensatory Changes in Mauthner Neurons in Goldfish Induced by Sensory Stimulation and Application of β-Amyloid

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Objectives. To study the structure and formation of Mauthner neuron dendrites in goldfish exposed to neurotoxic β-amyloid fragment 25–35 and prolonged sensory stimulation influencing the afferent inputs to these neurons. Materials and methods. Goldfish Mauthner neurons were studied by light and electron microscopy. Individual dendrites were identified, their volumes were determined, and synapse structure was assessed using virtual 3D images of Mauthner neurons obtained from serial sections of thickness 3 μm. The functional status of Mauthner neurons was evaluated indirectly from the motor lateralization of the fish. Results. Mauthner neurons responded to application of β-amyloid combined with subsequent prolonged sensory stimulation with decreases in the volume of the ventral dendrites, damage to their ultrastructure, and degeneration of a proportion of synapses. Degeneration of more active neurons was more significant than that of less active cells. Newly formed medial dendrites had greater volume and less damaged synapse ultrastructure than ventral dendrites. There were no differences in the sizes of specialized junctions between synapses of the same type on ventral and medial synapses. Conclusions. Medial dendrite formation is a compensatory reaction to dystrophy of the ventral dendrite due to the experimental treatment.

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Authors and Affiliations

  1. Experimental Neurobiology Laboratory, Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow District, Russia

    N. R. Tiras, I. B. Mikheyeva, G. Z. Mikhailova, N. A. Pen’kova & Ye. N. Bezgina

  2. Faculty of Biophysics and Biomedicine, Pushchino State Natural Sciences Institute, Russian Ministry of Education and Science, Pushchino, Moscow District, Russia

    N. R. Tiras

Authors
  1. N. R. Tiras
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  2. I. B. Mikheyeva
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  3. G. Z. Mikhailova
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  4. N. A. Pen’kova
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  5. Ye. N. Bezgina
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Correspondence to N. R. Tiras.

Additional information

Translated from Morfologiya, Vol. 154, No. 4, pp. 13–19, July–August, 2018.

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Tiras, N.R., Mikheyeva, I.B., Mikhailova, G.Z. et al. Compensatory Changes in Mauthner Neurons in Goldfish Induced by Sensory Stimulation and Application of β-Amyloid. Neurosci Behav Physi 49, 784–790 (2019). https://doi.org/10.1007/s11055-019-00802-3

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  • DOI: https://doi.org/10.1007/s11055-019-00802-3

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