Skip to main content
SpringerLink
Log in

Neurotoxicity Biomarkers as Potential Indicators of Spinal Cord Ischemia

  • Published:
Neuroscience and Behavioral Physiology Aims and scope Submit manuscript

Objectives. To study the concentration of antibodies to glutamate receptors in the serum and CSF of patients with vascular myelopathy in parallel with conventional diagnostic approaches. Materials and methods. The study group included 40 patients with vascular myelopathy: 10 patients with spinal stroke and 30 with subacute and chronic myelopathy. After application of exclusion criteria, the study group consisted of 27 patients. The reference group consisted of 30 patients with acute ischemic stroke and 30 with spondylogenic radiculopathy. The control group consisted of 15 healthy subjects. Patients underwent neurological investigations and MRI scans of the spine and spinal cord. Concentrations of antibodies to glutamate receptors (NMDA receptor NR2 fragments and AMPA/kainate receptors) were assessed by immunoenzyme analysis. Results and conclusions. Increases in titers of antibodies to NMDA receptor NR2 fragments were seen in the serum (p = 0.0001) and CSF (p = 0.0005) of patients with spinal cord ischemia as compared with the reference and control groups. Data on NR2 antibodies reliably detected myeloischemia as compared with analysis of antibodies to AMPA/kainate receptors and S100β protein. On the other hand, increased levels of antibodies to AMPA/kainate receptors were seen in patients with more severe disease, with more extensive lesions to the white matter. The authors take the view that determination of antibodies to glutamate receptors can be used in the diagnosis of vascular myelopathy and in the identification of disease severity.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. S. Weidauer, M. Nichtweiß, E. Hattingen, and J. Berkefeld, “Spinal cord ischemia: aetiology, clinical syndromes and imaging features,” Neuroradiology, 57, No. 3, 241–257 (2015), https://doi.org/10.1007/s00234-014-1464-6.

    Article  PubMed  Google Scholar 

  2. K. Nedeltchev, T. J. Loher, F. Stepper, et al., “Long-term outcome of acute spinal cord ischemia syndrome,” Stroke, 35, No. 2, 560–565 (2004), https://doi.org/10.1161/01.str.0000111598.78198.ec.

    Article  PubMed  Google Scholar 

  3. A. A. Skoromets, A. P. Skoromets, T. A. Skoromets, and T. P. Tissen, Spinal Angioneuropathy. Guidelines for Doctors, MEDpress-inform, Moscow (2003).

  4. Acute Spinal Cord Ischaemia Syndrome, https://radiopaedia.org/articles/acute-spinal-cord-ischaemia-syndrome, acc. Oct. 12, 2017.

  5. A. M. G. Sanchez, L. M. G. Posada, C. A. O. Toscano, and A. L. Lopez, “Diagnostic approach to myelopathies,” Rev. Colomb. Radiol., 22, No. 3, 1–21 (2011).

    Google Scholar 

  6. J. Novy, A. Carruzzo, P. Maeder, and J. Bogousslavsky, “Spinal cord ischemia: clinical and imaging patterns, pathogenesis, and outcomes in 27 patients,” Arch. Neurol., 63, No. 8, 1113–1120 (2006), https://doi.org/10.1001/archneur.63.8.1113.

    Article  PubMed  Google Scholar 

  7. T. Gennarelli, S. A. Dambinova, and J. D. Weissman, “Advances in diagnostics and treatment of neurotoxicity after sports-related injuries,” in: Acute Brain Impairment: Scientific Discoveries and Translational Research, P. V. Peplow et al. (eds.), Royal Society of Chemistry, Cambridge (2018), pp. 141–162.

  8. G. V. Ponomarev, S. A. Dambinova, and A. A. Skoromets, “Neurotoxicity in spinal cord impairments,” ibid., pp. 198–214.

  9. S. A. Dambinova, A. A. Skoromets, and A. P. Skoromets (eds.), Biomarkers for Cerebral Ischemia (development, study, and practice), IPK KOSTA, St. Petersburg (2013).

  10. J. D. Weissman, G. A. Khunteev, R. Heath, and S. A. Dambinova, “NR2 antibodies: Risk assessment of transient ischemic attack (TIA)/stroke in patients with history of isolated and multiple cerebrovascular events,” J. Neurol. Sci., 300, No. 1–2, 97–102 (2011), https://doi.org/10.1016/j.jns.2010.09.023.

    Article  CAS  PubMed  Google Scholar 

  11. E. G. Sorokina, Zh. B. Semenova, O. K. Granstrem, et al., “S100β protein and antibodies to it in the diagnosis of brain lesions in craniocerebral trauma in children,” Zh. Nevrol. Psikhiatr., 110, No. 8, 30–35 (2010).

    CAS  Google Scholar 

  12. J. J. Wong, J. Dufton, and S. A. Mior, “Spontaneous conus medullaris infarction in a 79 year-old female with cardiovascular risk factors: a case report,” J. Can. Chiropr. Assoc., 56, No. 1, 58–65 (2012).

    PubMed  PubMed Central  Google Scholar 

  13. N. Vongveeranonchai, M. Zawahreh, D. Strbian, and S. Sundararajan, “Evaluation of a patient with spinal cord infarction after a hypotensive episode,” Stroke, 45. No. 10, 203–205 (2014), https://doi.org/10.1161/Strokeaha.114.006490.

    Article  Google Scholar 

  14. J. R. Nance and M. R. Golomb, “Ischemic spinal cord infarction in children without vertebral fracture,” Pediatr. Neurol., 36, No. 4, 209–216 (2007), https://doi.org/10.1016/j.pediatrneurol.2007.01.006.

    Article  PubMed  PubMed Central  Google Scholar 

  15. Spinal Cord Infarction, Accessed October 12, 2017, https://emedicine.medscape.com/article/1164217-overview.

  16. G. Acker, U. C. Schneider, Z. Grozdanovic, et al., “Cervical disc herniation as a trigger for temporary cervical cord ischemia,” J. Spine Surg., 2, No. 2, 135–138 (2016), https://doi.org/10.21037/jss.2016.06.04.

    Article  PubMed  PubMed Central  Google Scholar 

  17. L. Restrepo and J. F. Guttin, “Acute spinal cord ischemia during aortography treated with intravenous thrombolytic therapy,” Tex. Heart Inst. J., 33, No. 1, 74–77 (2006).

    PubMed  PubMed Central  Google Scholar 

  18. M. I. Vargas, J. Gariani, R. Sztajzel, et al., “Spinal cord ischemia: practical imaging tips, pearls, and pitfalls,” A. J. Neuroradiol., 36, No. 5, 825–830 (2015), https://doi.org/10.3174/ajnr.a4118.

    Article  CAS  Google Scholar 

  19. C. Amanieu, M. Hermier, N. Peyron, et al., “Spinal dural arteriovenous fistula,” Diagn. Interv. Imaging, 95, No. 9, 897–902 (2014), https://doi.org/10.1016/j.diii.2013.08.007.

    Article  CAS  PubMed  Google Scholar 

  20. S. Weidauer, M. Nichtweiss, H. Lanfermann, and F. E. Zanella, “Spinal cord infarction: MR imaging and clinical features in 16 cases,” Neuroradiology, 44. No. 10, 851–857 (2002), https://doi.org/10.1007/s00234-002-0828-5.

    Article  PubMed  Google Scholar 

  21. W. Küker, M. Weller, U. Klose, et al., “Diffusion-weighted MRI of spinal cord infarction – high resolution imaging and time course of diffusion abnormality,” J. Neurol., 251, No. 7, 818–824 (2004), https://doi.org/10.1007/s00415-004-0434-z.

    Article  PubMed  Google Scholar 

  22. R. G. Nogueira, R. Ferreira, P. E. Grant, et al., “Restricted diffusion in spinal cord infarction demonstrated by magnetic resonance line scan diffusion imaging,” Stroke, 43, No. 2, 532–535 (2012), https://doi.org/10.1161/Strokeaha.111.624023.

    Article  PubMed  Google Scholar 

  23. S. Ram, A. Osman, V. N. Cassar-Pullicino, et al., “Spinal cord infarction secondary to intervertebral foraminal disease,” Spinal Cord, 42, No. 8, 481–484 (2004), https://doi.org/10.1038/sj.sc.3101583.

    Article  CAS  PubMed  Google Scholar 

  24. G. K. Kanellopoulos, X. M. Xu, C. Y. Hsu, et al., “White matter injury in spinal cord ischemia: protection by AMPA/kainate glutamate receptor antagonism,” Stroke, 31, No. 8, 1945–1952 (2000), https://doi.org/10.1161/01.str.31.8.1945.

    Article  CAS  PubMed  Google Scholar 

  25. S. A. Dambinova, R. L. Hayes, and K. K. Wang (eds.), Biomarkers for Traumatic Brain Injury, The Royal Society of Chemistry, Cambridge (2012).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Pavlov First St. Petersburg State Medical University, Russian Ministry of Health, St. Petersburg, Russia

    G. V. Ponomarev, T. V. Lalayan, S. A. Dambinova & A. A. Skoromets

Authors
  1. G. V. Ponomarev
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. T. V. Lalayan
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. S. A. Dambinova
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. A. A. Skoromets
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to G. V. Ponomarev.

Additional information

Translated from Zhurnal Nevrologii i Psikhiatrii imeni S. S. Korsakova, Vol. 118, No. 2, Iss. 1, pp. 52–57, February, 2018.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Ponomarev, G.V., Lalayan, T.V., Dambinova, S.A. et al. Neurotoxicity Biomarkers as Potential Indicators of Spinal Cord Ischemia. Neurosci Behav Physi 49, 743–748 (2019). https://doi.org/10.1007/s11055-019-00795-z

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11055-019-00795-z

Keywords

Search

Navigation