A Long and Difficult Path towards Understanding the Purpose of Sleep. The Period before Electrophysiology

We present a historical review of the concepts of Russian researchers regarding the mechanisms and functional roles of sleep – I. P. Pavlov and his predecessors (I. R. Tarkhanov and M. M. Manaseina) and students (N. A. Rozhanskii and K. M. Bykov). This analysis leads to the conclusion that sleep is linked with the realization of functional operations not previously associated with sleep and not addressed by current neuroscience. Thus, a real understanding of sleep functions can be expected to come only with a new neurophysiological paradigm.

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  1. 1.

    I. R. Tarkhanov, “Experiments on natural sleep in animals,” Zdorov’e, 121, 371–372 (1879).

    Google Scholar 

  2. 2.

    M. Shoifet, 100 Great Doctors, www.masiki.net/books/Mikhail-SHoyfet_100-velikikh-vrachey/79].

  3. 3.

    I. R. Tarkhanov, Psychomotor Center and their Development in Humans, Panteleev Press, St. Petersburg (1979).

  4. 4.

    I. P. Pavlov, Selected Works, Kh. S. Khoshtoyants (ed.), State Political Literature Press, Moscow, Leningrad (1949).

  5. 5.

    I. R. Tarkhanov, “Observations and experiments on the light-emitting apparatus of Italian fireflies,” in: Studies of the Russian Society of Doctors, St. Petersburg (1894–1895), pp. 104–112.

  6. 6.

    V. M. Kovalzon, “Maria Manasseina – a forgotten founder of sleep science,” J. Sleep Res., 3, No. 2, 128–134 (1994), https://doi.org/10. 1111/j.1365-2869.1994.tb00117.x.

  7. 7.

    V. M. Koval’zon, “A forgotten founder of biochemistry and somnology,” Priroda, 5, 85–89 (2012).

  8. 8.

    M. M. Manaseina, Sleep as a Third of the Life of Humans, or the Physiology, Pathology, Hygiene, and Psychology of Sleep, Russkaya Tipo-Litografiya, Moscow (1892).

  9. 9.

    M. de Manaseïne, “Quelques observations experimentales sur l’influence de l’insomnie absolue,” Arch. Ital. Biol., 21, 322–325 (1894).

    Google Scholar 

  10. 10.

    L. Daddi, “Sulle alterazioni degli elementi del sistema nervoso centrale nell’insomnia sperimenmtale,” Riv. Patol. Nerv. Ment., 3, 1–12 (1898).

    Google Scholar 

  11. 11.

    G. Tarozzi, “Sull’influenza del’insomnio sperimentale sulricambio materiale,” Riv. Patol. Nerv. Ment., 4, 1–23 (1899).

    Google Scholar 

  12. 12.

    C. Cirelli, P. J. Shaw, A. Rechtschaffen, and G. Tononi, “No evidence of brain cell degeneration after long-term sleep deprivation in rats,” Brain Res., 4, 184–193 (1999), https://doi.org/10.1016/S0006-8993 (99)01768-0.

  13. 13.

    I. P. Pavlov and L. N. Voznesenskii, “Sleep physiology,” in: Twenty Years of Objective Investigation of Higher Nervous Activity (behavior) in Animals, Nauka, Moscow (1973).

  14. 14.

    N. A. Rozhanskii, Sleep Physiology, State Medical Literature Press, Moscow (1954).

  15. 15.

    R. A. Lemkul’, “Comparison of the shift between sleep and waking in normal and decerebrate pigeons,” Fiziol. Zh. SSSR im. Sechenova, 19, No. 3, 622–631 (1935).

    Google Scholar 

  16. 16.

    V. M. Koval’zon, “The role of the orexinergic system of the brain in regulating waking and sleep,” Effekt. Farmakoter. Nevrol. Psikhiatr., Spec. Iss., Sleep and Its Disorders, 19, 6–16 (1916).

    Google Scholar 

  17. 17.

    V. M. Koval’zon, Basic Somnology. Physiology and Neurochemistry of the Sleep–Waking Cycle, Binom. Lab. Znanii, Moscow (2011).

  18. 18.

    Pavlov’s Clinical Wednesdays 1931–1933, USSR Academy of Sciences Press (1954), Vol. 1., pp. 104–105, 164–165, 209–212,

  19. 19.

    I. N. Pigarev and M. L. Pigareva, “Asynchronous development of sleep as the likely cause of decreased cognitive functions and the occurrence of a number of pathological states associated with the ‘sleep–waking’ cycle,” Effekt. Farmakoter. Nevrol. Psikhiatr., Spec. Iss., Sleep and Its Disorders, 22, 6–14 (2014).

    Google Scholar 

  20. 20.

    I. N. Pigarev and M. L. Pigareva, “Partial sleep in the context of augmentation of brain function,” Front. Syst. Neurosci., 8, 75–87 (2014), https://doi.org/10.3389/fnsys.2014.00075.

  21. 21.

    I. S. Aleksandrov, K. M. Bykov, G. E. Vladimirov, G. A. Dmitriev, N. G. Malitskaya, M. Ya. Mikhel’son, A. M. Nikitina, G. N. Pribytkova, A. V. Rikkl’, and A. A. Rogov, “Changes in animals’ bodies in prolonged sleep deprivation,” in: K. M. Bykov, Selected Works, Yu. M. Protusevich (ed.), Medgiz, Moscow (1958).

  22. 22.

    I. N. Pigarev and M. L. Pigareva, “The state of sleep and the current brain paradigm,” Front. Syst. Neurosci., 9, 139–143 (2015), https:// doi.org/10.3389/fnsys.2015.00139.

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Correspondence to I. N. Pigarev.

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Translated from Zhurnal Nevrologii i Psikhiatrii imeni S. S. Korsakova, Vol. 117, No. 4, Iss. II, Sleep Disorder, pp. 91–97, April, 2017.

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Pigarev, I.N., Pigareva, M.L. A Long and Difficult Path towards Understanding the Purpose of Sleep. The Period before Electrophysiology. Neurosci Behav Physi 49, 75–80 (2019). https://doi.org/10.1007/s11055-018-0695-0

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  • sleep
  • sleep deprivation