High anxiety is a personality features which is largely genetically determined and is due to the functioning of the limbic system and the activity of cerebral formations involved in maintaining waking and the development of sleep. Analysis of experiments on animals and clinical observations indicates that this feature, determining an individual’s own responses, promotes the development of anxiety and anxiety disorders which, due to suppression of GABA-benzodiazepine inhibitory influences, has adverse effects on the duration and quality of nocturnal sleep. Phenazepam, acting via its anxiolytic properties, inactivates foci of arousal in the nervous system, countering the negative manifestations of anxiety, resulting in a somnogenic action which normalizes sleep impairments.
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Translated from Zhurnal Nevrologii i Psikhiatrii imeni S. S. Korsakova, Vol. 117, No. 4, Iss. II, Sleep Disorder, pp. 12–18, April, 2017.
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Verbitskii, E.V. Interaction between Anxiety and Sleep in Experimental Studies and Clinical Practice. Neurosci Behav Physi 49, 7–12 (2019). https://doi.org/10.1007/s11055-018-0683-4
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DOI: https://doi.org/10.1007/s11055-018-0683-4