We report here our studies of the relationship between mitogen-activated secretion of cytokines by splenocytes and the nature of behavior in (C57BL/6 × DBA/2)F1 mice in environments with different levels of spatial complexity: simple, in the form of the home cage, an enriched cage, and a maze. Increases in aggressive and neurotic manifestations in social conditions occurring only in the enriched environment were accompanied by suppression of the secretion of interleukins IL-2, IL-4, IL-6, and IL-10 independently of their structural-functional properties. The opposite effect, with significant increases in the production of all the cytokines studied, was seen in the case of stereotypical goal-directed behavior in the maze. It is suggested that the cellular elements of the immune system – splenocytes – are involved in mediating the body’s highly differentiated adaptive response induced by the social and cognition factors, the extent of which was determined by specific physiological-biochemical systems.
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References
V. V. Grinevich, O. V. Volkova, and I. G. Akmaev, “Neuroimmunoendocrine interactions in the hypothalamus-hypophysis-adrenal cortex system in inflammation,” Usp. Sovr. Estestv. Med. Nauki., No. 3, 10–14 (2003).
M. V. Kondashevskaya, Heparin – a New Paradigm for the Effects of Actions, Studiya MDV, Moscow (2011).
M. V. Kondashevskaya, M. E. Diatroptov, M. A. Diatroptova, and K. A. Nikol’skaya, “Morphofunctional characteristics of the thymus and spleen after food deprivation and information loading in BALB/c mice,” Klin. Eksper. Morfol., No. 1, 39–44 (2013).
V. N. Kostenkova and K. A. Nikol’skaya, “Psychoemotional manifestations in the hippocampetomized rats,” Ros. Fiziol. Zh., 89, No. 7, 868–878 (2003).
K. A. Nikol’skaya, “An information systems approach to studies of cognitive activity in animals,” in: The Great Handbook of Higher Nervous Activity and Neurophysiology, LINOR, Moscow (2009).
K. A. Nikol’skaya, M. V. Kondashevskaya, and L. V. Eremina, “Individual sensitivity of Wistar rats to the actions of piracetam,” Ros. Fiziol. Zh., 93, No. 11, 1308–1318 (2007).
M. A. Samotrueva, D. L. Teplyi, and I. N. Tyurenkov, “Pathways mediating neuro-immunoendocrine interactions,” Estestv. Nauki, 4, No. 29, 112–130 (2009).
V. V. Serkova, L. V. Eremina, K. A. Nikol’skaya, and M. V. Kondashevskaya, “The role of the hippocampus in the expression of hormonal activity in various feeding states in (C57BL/6 × DBA/2)F1 mice,” Fund. Issled. Biol. Nauki, 8, 105–109 (2013).
G. M. Teletaeva, “Cytokines in antitumor immunity,” Praktich. Onkol., 8, No. 4, 211–218 (2007).
S. T. Christie and P. Schrater, “Cognitive cost as dynamic allocation of energetic resources,” Front. Neurosci., 9, No. 289, 1–15 (2015).
A. J. Hannan, “Environmental enrichment and brain repair: harnessing the therapeutic effects of cognitive stimulation and physical activity to enhance experience-dependent plasticity,” Neuropathol. Appl. Neurobiol., 40, No. 1, 13–25 (2014).
H. Himmerich, J. Fischer, K. Bauer, et al., “Stress-induced cytokine changes in rats,” Eur. Cytokine Netw., 24, No. 2, 97–103 (2013).
R. W. Johnson, “Immune and endocrine regulation of food intake in sick animals,” Domest. Anim. Endocrinol., 15, No. 5, 309–319 (1998).
J. M. Peake, P. Della Gatta, K. Suzuki, and D. C. Nieman, “Cytokine expression and secretion by skeletal muscle cells: regulatory mechanisms and exercise effects,” Exerc. Immunol. Rev., 21, 8–25 (2015).
B. K. Pedersen and M. A. Febbraio, “Muscle as an endocrine organ: focus on muscle-derived interleukin-6,” Physiol. Rev., 88, No. 4, 1379–1406 (2008).
A. M. Petersen and B. K. Pedersen, “The anti-inflammatory effect of exercise,” J. Appl. Physiol., 98, No. 4, 1154–1162 (2005).
A. F. Richwine, N. L. Sparkman, R. N. Dilger, et al., “Cognitive deficits in interleukin-10-deficient mice after peripheral injection of lipopolysaccharide,” Brain Behav. Immun., 23, No. 6, 794–802 (2009).
G. Singhal, E. J. Jaehne, F. Corrigan, and B. T. Baune, “Cellular and molecular mechanisms of immunomodulation in the brain through environmental enrichment,” Front. Cell. Neurosci., 8, No. 97, 1–29 (2014).
P. P. Tsai, H. D. Stelzer, H. J. Hedrich, and H. Hackbarth, “Are the effects of different enrichment designs on the physiology and behaviour of DBA/2 mice consistent?” Lab. Anim., 37, No. 4, 314–327 (2003).
H. Wang and J. Ye, “Regulation of energy balance by inflammation: common theme in physiology and pathology,” Rev. Endocr. Metab. Disord., 16, No. 1, 47–54 (2015).
S. S. Zalcman and A. Siegel, “The neurobiology of aggression and rage: role of cytokines,” Brain Behav. Immun., 20, No. 6, 507–514 (2006).
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Translated from Rossiiskii Fiziologicheskii Zhurnal imeni I. M. Sechenova, Vol. 103, No. 3, pp. 307–317, March, 2017.
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Nikol’skaya, K.A., Kondashevskaya, M.V. Cytokine Secretion by Splenocytes in Response to Behavior in (C57BL/6 × DBA/2)F1 Mice in Environments with Different Levels of Complexity. Neurosci Behav Physi 48, 823–829 (2018). https://doi.org/10.1007/s11055-018-0635-z
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DOI: https://doi.org/10.1007/s11055-018-0635-z