Neurodegenerative diseases result from a complex interaction between unfavorable environmental factors and the individual characteristics of the genome which predispose to disease development. Drosophila provides a suitable system for studies of the relationship between genomic organization and chromosomal architecture producing cognitive impairments. We present here the results of complex investigations of the effects of attenuation of the geomagnetic field (by screening) on genomic transcriptional activity, learning ability, and the formation of intermediate-term memory in Drosophila melanogaster. In this stress, a relationship was seen between modifications to transcriptional activity and the structure of the LIMK1 gene – a key enzyme in the actin remodeling cascade. Impairments to intermediate-term memory were seen on exposure to a weak static magnetic field in Canton-S wild-type flies. Conversely, this same stress restored learning ability and memory formation in agnts3 mutants.
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Nikitina, E.A., Medvedeva, A.V., Gerasimenko, M.S. et al. A Weakened Geomagnetic Field: Effects on Genomic Transcriptiln Activity, Learning, and Memory in Drosophila Melanogaster. Neurosci Behav Physi 48, 796–803 (2018). https://doi.org/10.1007/s11055-018-0632-2
- weak static magnetic field
- neurodegenerative diseases
- learning and memory
- histone acetylation