Chronic (10 days)administration of the atypical antipsychotic quetiapine (3.75 mg/kg) induced significant suppression of the IgM immune response in mice with aggressive behavior formed as a result of prolonged (14 days in CBA mice, 20 days in C57BL/6J mice) confrontations and in animals with unaltered psychoemotional status. The immunosuppressive action of quetiapine was independent of the genotype of the mice and the route (i.p. or p.o.) and scheme (single or repeated) of administration. Possible serotonin (5-HT) and dopamine (DA) receptor mechanisms of the immunomodulatory effects of quetiapine are discussed.
Similar content being viewed by others
References
E. L. Al’perina, “Contribution of the dopaminergic system to the mechanisms of immunomodulation,” Usp. Fiziol. Nauk., 345, No. 3, 45–56 (2014).
E. L. Al’perina and T. A. Pavina, “Changes in immunological reactivity in C57BL/6J mice in conditions of zoosocial conflict,” Byull. Eksperim. Biol. Med., 122, No. 11, 541–543 (1996).
T. P. Vetlugina, O. A. Lobacheva, E. L. Al’perina, et al., “Clinical experimental studies of the immunomodulatory effect of Solian,” Vestn. Ross. Akad. Med. Nauk., No. 12, 13–17 (2012).
T. P. Vetlugina, T. I. Nevidimova, O. A. Lobacheva, and V. B. Nikitina, The Technology of Immunocorrection in Mental Disorders, Tomsk University, Tomsk (2010).
S. M. Davydova, M. A. Cheido, M. M. Gevorgyan, and G. V. Idova, “Effects of activation and blockade of 5-HT2A receptors on the immune response,” Byull. Eksperim. Biol. Med., 150, No. 8, 184–186 (2010).
L. V. Devoino, G. V. Idova, and E. L. Al’perina, Psychoneuroimmunomodulation: Behavior and Immunity, Nauka, Novosibirsk (2009).
L. V. Devoino, E. L. Al’perina, E. L. Podgornaya, et al., “Effects of serotonin and 5-hydroxyindoleacetic acid contents in brain structures on the formation of the immune response in aggressive C57BL/6J mice,” Byull. Eksperim. Biol. Med., 130, neuron 10, 399–401 (2000).
G. V. Idova, E. L. Al’perina, O. A. Lobacheva, et al., “Effects of amisulpiride on immunological reactivity,” Eksperim. Klin. Farma kol., 76, No. 5, 14–17 (2013).
G. V. Idova and M. A. Cheido, “Stimulation of the immune response on blockade of serotonin receptors with ciproheptadine,” Byull. Eksperim. Biol. Med., 103, No. 4, 440–442 (1987).
G. V. Idova, M. A. Cheido, and E. N. Zhukova, “Effects of activation and blockade of dopamine D2 receptors on the immune response in mice with different types of behavior,” Ros. Fiziol. Zh., 92, 552–559 (2006).
V. S. Naumenko, D. V. Bazovkina, and E. M. Kondaurova, “Functional interaction of 5-HT1A and 5-HT2A receptors in the brain,” Zh. Vyssh. Nerv. Deyat., 65, No. 2, 240–247 (2015).
E. Alperina, E. Zhukova, G. Idova, et al., “Effect of activation and blockade of serotonin 5-HT1A receptors on the immune response in rats selected for different levels of aggressiveness,” Pharmacol. Pharmacy, 6, 451–459 (2015).
D. O. Borroto-Escuela, J. Pintsu, T. Schäfer, et al., “Multiple D2 heteroreceptor complexes: new targets for treatment of schizophrenia,” Ther. Adv. Psychopharmacol., 6, No. 2, 77–94 (2016).
L. Devoino, E. Alperina, and T. Pavina, “Immunological consequences of the reversal of social status in C57 BL/6J mice,” Brain Behav. Immunity, 17, No. 1, 28–34 (2003).
J. Ichikawa, H. Ishii, S. Bonaccorso, et al., “5-HT (2A) and D(2) receptor blockade increases cortical DA release via 5-HT (1A) receptor activation: a possible mechanism of atypical antipsychotic-induced cortical dopamine release,” J. Neurochem., 76, No. 5, 1521–1531 (2001).
G. V. Idova, E. L. Alperina, and M. A. Cheido, “Contribution of brain dopamine, serotonin, and opioid receptors in the mechanisms of neuroimmunomodulation: evidence from pharmacological analysis,” Int. Immunopharmacol., 12, No. 4, 618–625 (2012).
G. Idova, S. Davydova, E. Alperina, et al., “Serotoninergic mechanisms of immunomodulation under different psychoemotional states: I. A role of 5-HT1A receptor subtype,” Int. J. Neurosci., 118, No. 11, 1594–1608 (2008).
N. N. Kudryavtseva, “The sensory contact model for the study of aggressive and submissive behaviors in male mice,” Aggressive Behav., 17, No. 5, 285–291 (1991).
C. S. Ladics, “Primary immune response to sheep red blood cells (SRBC) as conventional T-cell dependent antibody response (TDAR) test,” J. Immunotoxicol., 4, No. 2, 149–152 (2007).
F. Mei, S. Guo, Y. He, et al., “Quetiapine, an atypical antipsychotic, is protective against autoimmune-mediated demyelination by inhibiting effector T-cell proliferation,” PLoS One, 7, No. 8, e42746 (2012).
H. Y. Meltzer and B. W. Massey, “The role of serotonin in the action of atypical antipsychotic drugs,” Curr. Opin. Pharmacol., 11, No. 1, 59–67 (2011).
C. B. Nemeroff, B. Kinkead, and J. Goldstein, “Quetiapine: preclinical studies, pharmacokinetics, drug interactions, and dosing,” J. Clin. Psychiatry, 63, No. 13, 5–11 (2002).
T. C. Pellegrino and B. M. Bayer, “Role of central 5-HT2 receptors in fluoxetine-induced decreases in T lymphocyte activity,” Brain Behav. Immun., 16, No. 2, 87–103 (2002).
N. K. Popova, V. S. Naumenko, R. V. Kozhemiakina, and I. Z. Pliusnina, “Functional characteristics of serotonin 5-HT2A and 5-HT2C receptors and the expression of 5-HT2A and 5-HT2C receptor genes in aggressive and non-aggressive rats,” Neurosci. Behav. Physiol., 40, No. 4, 357–361 (2010).
M. Sakaue, Y. Ago, C. Sowa, et al., “Modulation by 5-HT2A receptors of aggressive behavior in isolated mice,” Jpn. J. Pharmacol., 89, No. 1, 89–92 (2002).
A. Takahashi, I. M. Quadros, R. M. de Almeida, and K. A. Miczek, “Behavioural and pharmacogenetics of aggressive behavior,” Curr. Top. Behav. Neurosci., 12, 73–138 (2012).
S. Tauscher-Wisniewski, S. Kapur, J. Tauscher, et al., “Quetiapine as an effective antipsychotic in first-episode schizophrenia despite only transiently high dopamine-2 receptor blockade,” J. Clin. Psychiatry, 63, No. 11, 992–997 (2002).
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Rossiiskii Fiziologicheskii Zhurnal imeni I. M. Sechenova, Vol. 103, No. 1, pp. 38–44, January, 2017.
Rights and permissions
About this article
Cite this article
Idova, G.V., Cheido, M.A., Zhukova, E.N. et al. Effects of the Atypical Antipsychotic Quetiapine on the Immune Response in Aggressive Mice in a Model of Social Stress. Neurosci Behav Physi 48, 506–510 (2018). https://doi.org/10.1007/s11055-018-0592-6
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11055-018-0592-6