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Association between the 5-HTTLPR Polymorphism of the Serotonin Transporter Gene with the Efficiency and Tolerability of Selective Serotonin Reuptake Inhibitors

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Objective. To identify the association between the 5-HTTLPR polymorphism of the serotonin transporter gene with the efficacy and tolerability of antidepressant therapy with a selective serotonin reuptake inhibitor (SSRI). Materials and methods. A complex clinical-psychopathological and genetic study of 38 patients with depression during SSRI treatment was conducted. Results and conclusions. Statistical associations between the 5-HTTLPR polymorphism and the levels of remission and tolerability were identified: carriers of the SS genotype rarely achieved remission and developed more severe side effects.

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Authors and Affiliations

  1. Department of Psychiatry and Narcology, Sechenov First Moscow State Medical University, Moscow, Russia

    N. N. Ivanets, M. A. Kinkul’kina, Yu. G. Tikhonova & T. I. Avdeeva

  2. Research Department of Mental Health, Sechenov First Moscow State Medical University, Moscow, Russia

    N. N. Ivanets, M. A. Kinkul’kina, Yu. G. Tikhonova & T. A. Izyumina

  3. Transfusion Medicine Joint Equipment Center, Sechenov First Moscow State Medical University, Moscow, Russia

    A. A. Ragimov, N. G. Dashkova, O. E. Kuznetsov & A. V. Matveev

  4. Neurology Scientific Center, Russian Academy of Sciences, Moscow, Russia

    S. V. Orlov

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  1. N. N. Ivanets
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  2. M. A. Kinkul’kina
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  3. Yu. G. Tikhonova
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Correspondence to N. N. Ivanets.

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Translated from Zhurnal Nevrologii i Psikhiatrii imeni S. S. Korsakova, Vol. 116, No. 2, Iss. 1, pp. 46–51, February, 2016.

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Ivanets, N.N., Kinkul’kina, M.A., Tikhonova, Y.G. et al. Association between the 5-HTTLPR Polymorphism of the Serotonin Transporter Gene with the Efficiency and Tolerability of Selective Serotonin Reuptake Inhibitors. Neurosci Behav Physi 47, 386–392 (2017). https://doi.org/10.1007/s11055-017-0411-5

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  • DOI: https://doi.org/10.1007/s11055-017-0411-5

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