Dynamics of Histological Changes in the Frontal Cortex of the Brain in Rats Subjected to Antenatal Exposure to Alcohol
The aim of the present work was to undertake a comparative study of the effects of prenatal alcoholization of the histological characteristics of neurons in the frontal cortex of the brains of rats of different ages. Experiments were performed on 175 mongrel white rats – the offspring of 25 females given 15% ethanol as drinking solution throughout pregnancy. The cerebral cortex was studied on postnatal days 2–90 using histological, histochemical, and morphometric methods. An increase (on days 2 and 5) followed by a decrease (on days 10 and 90) was seen in cortical thickness, with a decrease in neuron body size (on days 20–90), a decrease in the number of neurons in cortical layer V, a decrease in the number of normochromic cells, and increases in the numbers of hyperchromic shrunken neurons and ghost cells throughout the study period. Antenatal alcoholization in rats induced various histological changes in the frontal cortex, which were long-lasting and progressive during postnatal ontogeny.
Keywordsfrontal cortex neurons antenatal alcoholization
Unable to display preview. Download preview PDF.
- 1.N. V. Batin, Computerized Statistical Data Analysis: Textbook, Institute of Scientific Training, Belarus Academy of Sciences, Minsk (2008).Google Scholar
- 2.S. M. Zimatkin and E. I. Bon’, “Antenatal alcoholization: damage to the internal organs,” Nov. Med. Biol. Nauk., No. 2, 168–174 (2013).Google Scholar
- 3.S. M. Zimatkin and E. I. Bon’, “Fetal alcohol syndrome: behavioral and neurological impairments,” Zh. Grodn. Med. Univ., No. 2, 14–17 (2013).Google Scholar
- 4.S. M. Zimatkin and E. I. Bon’, Fetal Alcohol Syndrome: Monograph, Novoe Znanie, Minsk (2014).Google Scholar
- 5.S. M. Zimatkin and E. I. Bon’, “Effects of alcohol on the developing brain,” Morfologiya, 145, No. 2, 79–88 (2014).Google Scholar
- 6.N. N. Karkishchenko and S. V. Gracheva, Handbook for Laboratory Animals and Alternative Models in Biomedical Studies, Profil-2S, Moscow (2010).Google Scholar
- 7.E. N. Popova, Ultrastructure of the Brain, Alcohol, and Offspring, Nauchnyi Mir, Moscow (2010).Google Scholar
- 10.S. M. de la Monte and J. R. Wands, “Role of central nervous system insulin resistance in fetal alcohol spectrum disorders,” J. Popul. Ther. Clin. Pharmacol., 17, No. 3, 390–404 (2010).Google Scholar
- 13.G. Paxinos and C. Watson, The Rat Brain in Stereotaxic Coordinates, Academic Press, London (1998).Google Scholar