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Experience in the Use of Recombinant Interleukin-2 in the Treatment of Children with Encephalitis

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Study aim. The efficacy of Russian-produced recombinant interleukin-2 (IL-2) in the complex treatment of encephalitis was studied in children. Materials and methods. A total of 40 patients aged from six months to 17 years were treated. Drug was given at a dose of 0.5 mg/day by i.v. infusion for three days in acute cases and for five days in chronic cases. The reference group consisted of 35 patients with encephalitis, treated without study drug. Results. Use of recombinant IL-2 decreased the duration of developing symptoms by 5.4 ± 1.3 days, decreased neurological deficit on the EDSS on discharge from hospital by 1.6 ± 0.2 points, and decreased the frequency of acute exacerbations from 22.9% to 5% and the frequency of developing multiple sclerosis over three years from 17.1% to 2.5% (p ≤ 0.05). Efficacy correlated with positive changes in immunological parameters 3–4 weeks after treatment ended. Studies of multimodal evoked potentials in the brain during use of this drug showed that it had positive influences on the central afferent conduction time. There was a reduction in the proportion of patients with focal changes on follow-up MRI scans. Conclusions. Recombinant IL-2 is recommended for the treatment of children with encephalitis.

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Authors and Affiliations

  1. Research Institute of Childhood Infections, St. Petersburg, Russia

    N. V. Skripchenko, G. P. Ivanova, G. F. Zheleznikova, V. N. Komantsev & A. V. Surovtseva

  2. Department of Infectious Diseases in Children, Faculty of Postgraduate and Further Professional Education, St. Petersburg State Pediatric Medical University, St. Petersburg, Russia

    N. V. Skripchenko & G. P. Ivanova

Authors
  1. N. V. Skripchenko
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  2. G. P. Ivanova
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  3. G. F. Zheleznikova
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  4. V. N. Komantsev
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  5. A. V. Surovtseva
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Correspondence to N. V. Skripchenko.

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Translated from Zhurnal Nevrologii i Psikhiatrii imeni S. S. Korsakova, Vol. 114, No. 5, Iss. I, pp. 27–32, May, 2014.

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Skripchenko, N.V., Ivanova, G.P., Zheleznikova, G.F. et al. Experience in the Use of Recombinant Interleukin-2 in the Treatment of Children with Encephalitis. Neurosci Behav Physi 45, 1095–1100 (2015). https://doi.org/10.1007/s11055-015-0191-8

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  • DOI: https://doi.org/10.1007/s11055-015-0191-8

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