The aim of the present work was to study the interaction between the ability to learn a new motor skill and the preference for the right or left forelimb on performing manipulatory movements in rats. The new skill was the Morris water test, in which the animals were initially trained to find a platform hidden beneath the water by swimming from the sector opposite the platform and then by swimming from sectors located to the left and right of the platform. Forelimb preference was identified in terms of the animal’s grasping food from a narrow horizontal tube, such that the rats were divided into left-handed and right-handed animals. Our findings showed that a change in the start position for the first episodes of swimming from the left or right sector significantly increased the platform-finding time in right-handed rats, as compared with left-handed.
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Belcheva, I., Tashev, R., and Belcheva, S., “Hippocampal asymmetry in serotonergic modulation of learning and memory in rats. Laterality: Asymmetries of Body,” Brain Cogn., 12, No. 6, 475–486 (2007).
Bianki, V. L., Asymmetry in Animal Brains, Nauka, Leningrad (1985).
Braun, A. A., Graham, D. L., Schaefer, T. L., et al., “Dorsal striatal dopamine depletion impairs both allocentric and egocentric navigation in rats,” Neurobiol. Learn. Mem., 97, No. 4, 402–408 (2012).
Churchwell, J. C., Morris, A. M., Musso, N. D., and Kesner, R. P., “Prefrontal and hippocampal contributions to encoding and retrieval of spatial memory,” Neurobiol. Learn. Mem., 93, No. 3, 415–421 (2010).
Collins, R. L., “On the inheritance of direction and degree of asymmetry,” in: Cerebral Lateralization in Nonhuman Species, Glick, S. D. (ed.), Academic Press, New York (1985), pp. 41–53.
De Bruin, J. P, Moita, M. P., de Brabander, H. M., and Joosten, R. N., “Place and response learning of rats in a Morris water maze: differential effects of fimbria fornix and medial prefrontal cortex lesions,” Neurobiol. Learn. Mem., 75, No. 2, 164–178 (2001).
Denenberg, V. H., “Evolution proposes and ontogeny disposes,” Brain Lang., 73, No. 2, 274–296 (2000).
Denenberg, V. H., Mobraaten, L. E., Sherman, G. F., et al., “Effects of autoimmune uterine/maternal environment on cortical ectopias, behavior and autoimmunity,” Brain Res., 563, No. 1, 114–122 (1991).
Ethier, K, Le Marec, N., Rompre, P. P., and Godbout, R. “Spatial strategy elaboration in egocentric and allocentric tasks following medial prefrontal cortex lesions in the rat,” Brain Cogn., 46, No. 1–2, 134–135 (2001).
Fanselow, M. S. and Dong, H.-W., “Are the dorsal and ventral hippocampus functionally distinct structures?,” Neuron, 65, 7–19 (2010).
Geodakyan, V. A., “Homo sapiens on the pathway to asymmetrization,” in: Anthropology in the Third Millennium, Moscow (2003), Vol. 1, pp. 170–201.
Ioffe, M. E., Pletneva, E. V., and Stashkevich, I. S., “The nature of functional motor asymmetry in animals: the state of the problem,” Zh. Vyssh. Nerv. Deyat., 52, No. 1, 5–16 (2002).
Kleinknecht, K. R., Bedenk, B T., Kaltwasser, S. F., et al., “Hippocampusdependent place learning enables spatial flexibility in C57BL6/N mice,” Front. Behav. Neurosci. , 6, 1–7 (2012).
Klur, S., Muller, C., Pereira de Vasconcelos, A., et al., “Hippocampaldependent spatial memory functions might be lateralized in rats: An approach combining gene expression profiling and reversible inactivation,” Hippocampus, 19, No. 9, 800–816 (2009).
Levitan, S. and Reggia, J. A., “A computational model of lateralization and asymmetries in cortical maps,” Neural Comput., 12, No. 9, 2037–2062 (2000).
Lipp, H. P., Collins R. L., Hausheer-Zarmakupi, Z., et al., “Paw preference and intra-/infrapyramidal mossy fibers in the hippocampus of the mouse,” Behav. Genet., 26, No. 4, 379–390 (1996).
McNamara, R. K. and Skeleton, R. W., “Effects of intracranial infusions of chlordiazepoxide on spatial learning in the Morris water maze. II. Neuropharmacological specificity,” Behav. Brain Res., 59, No. 1–2, 193–204 (1993).
Miklyaeva, E. I., Ioffe, M. E., and Kulikov, M. A., “Innate versus learned factors determining limb preference in the rat,” Behav. Brain Res., 46, No. 2, 103–115 (1991).
Mogensen, J., Moustgaard A., Khan, U., et al., “Egocentric spatial orientation in a water maze by rats subjected to transection of the fimbriafornix and/or ablation of the prefrontal cortex,” Brain Res. Bull., 65, No. 1, 41–58 (2005).
Morris, R. G. M., Schenk, F., Tweedie, F., and Jarrard, L. E., “Ibotenate lesions of hippocampus and/or subiculum: dissociating components of allocentric spatial learning,” Eur. J. Neurosci., 2, No. 12, 1016–1028 (1990).
Morris, R. G. M., “Development of water-maze procedure for studying spatial learning in the rat,” J. Neurosci. Meth., 11, 47–60 (1984).
Nalivaeva, N. N., Plesneva, S. A., Chekulaeva, U. B., et al., “Some biochemical features of the rat sensorimotor cortex in right-handed, left-handed, and ambidextrous rats,” Zh. Evol. Biokhim. Fiziol., 32, No. 1, 75–81 (1996).
Neveu, P. J., “Asymmetrical brain modulation of the immune response,” Brain Res., 17, No. 1, 101–107 (1991).
Olton, D. S., Walker, J. A., and Gage, F. H., “Hippocampal connections and spatial discrimination,” Brain Res., 139, No. 2, 295–308 (1978).
Peterson, G. M., “Mechanisms of handedness in the rat,” Comp. Psychol. Monogr. , 9, 1–67 (1934).
Pleskacheva, M. G., Zorina, Z. A., Nikolenko, D. L., et al., “Behavior in the Morris water test in Krushinskii–Molodkina rats bred for elevated convulsive readiness,” Zh. Vyssh. Nerv. Deyat., 52, No. 3, 356–365 (2002).
Podol’skii, I. Ya. and Shcheglov, I. V., “Effects of protein synthesis inhibition in the central nervous system on the formation of long-term memory on solving various behavioral tasks,” Zh. Vyssh. Nerv. Deyat., 54, No. 1, 59–67 (2004).
Springer, S and G. Deutsch, Left Brain, Right Brain. Asymmetry of the Brain [Russian translation], Mir, Moscow (1983).
Stashkevich, I. S. and Kulikov M. A., “On the question of the formation of a lateralized motor skill in rats,” Zh. Vyssh. Nerv. Deyat., 50, No. 3, 457–463 (2000).
Stashkevich, I. S., Pletneva, E. V., and Kulikov, M. A., “Differences in the resistance of motor preference in rats to forced retraining,” Zh. Vyssh. Nerv. Deyat., 51, No. 6, 683–689 (2001).
Tan, U. and Kutlu, N., “The relationships between paw preference and the right- and left-brain weights in male and female adult cats: ipsilateral and contralateral motor control with regard to asymmetric postural and manipulative actions,” Int. J. Neurosci., 69, No. 1–4, 21–34 (1993).
Varlinskaya, E. I., Chasovnikova, T. I., Makarova, T. M., et al., “Consequences of intraspecies isolation at adult age in rats (right-handed, left-handed, and ambidextrous animals),” Zh. Vyssh. Nerv. Deyat., 43, No. 6, 1124–1128 (1993).
Wu, H. M., Wang, C., Wang, X. L., et al., “Correlations between angiotensinase activity asymmetries in the brain and paw preference in rats,” Neuropeptides, 44, No. 3, 253–259 (2010).
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Translated from Zhurnal Vysshei Nervnoi Deyatel’nosti imeni I. P. Pavlova, Vol. 64, No. 2, pp. 201–207, March–April, 2014.
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Budilin, S.Y., Pletneva, E.V., Ioffe, M.E. et al. Motor Asymmetry and the Learning of New Skills by Animals. Neurosci Behav Physi 45, 1063–1067 (2015). https://doi.org/10.1007/s11055-015-0186-5
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DOI: https://doi.org/10.1007/s11055-015-0186-5