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Effects of Environmental Conditions on Behavior in an Open Field Test in Rats Born to Females with Chronic Alcoholization

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The aim of the present work was to study the morphology of the brain and to analyze the behavior of the offspring of female rats with chronic alcohol intoxication. Experiments were performed using 60-day-old animals born to mothers with chronic alcoholic hepatobiliary system disease. Over a period of 1.5 months, one group of animals was reared in standard conditions, the other in an enriched environment. Behavior was analyzed in an open field test. The thicknesses of the cortex and its molecular layer were also studied. The offspring of mothers with chronic hepatobiliary system disease were characterized by decreased movement and exploratory activity and increased emotional reactivity, which were accompanied by changes in the structure of the cortex. Prolonged placing of “alcoholic” rats in the enriched environment for 1.5 months promoted increases in movement and exploratory activity and emotional reactivity, and produced changes in the structure of the cortex.

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Authors and Affiliations

  1. South Urals State Medical University, Russian Ministry of Health, Chelyabinsk, Russia

    V. A. Vakhnin & G. V. Bryukhin

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  1. V. A. Vakhnin
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  2. G. V. Bryukhin
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Correspondence to V. A. Vakhnin.

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Translated from Rossiiskii Fiziologicheskii Zhurnal imeni I. M. Sechenova, Vol. 100, No. 4, pp. 406–417, April, 2014.

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Vakhnin, V.A., Bryukhin, G.V. Effects of Environmental Conditions on Behavior in an Open Field Test in Rats Born to Females with Chronic Alcoholization. Neurosci Behav Physi 45, 1003–1009 (2015). https://doi.org/10.1007/s11055-015-0179-4

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  • DOI: https://doi.org/10.1007/s11055-015-0179-4

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