Regression analysis of the connections between changes in histological brain structures (neurons, neuroglia, and microvessels) and the extent of poisoning with ethanol (blood and urine ethanol concentrations) was performed. Specimens were obtained from 40 male and female corpses aged 20–81 years. Decreases in microvessel diameter in the cerebral cortex and cerebellum and increases in microvessel diameter in the white matter, along with increases in the numbers of vessels with stasis, in the numbers of astrocytes with cytoplasmic granularity, and in various signs of cerebral edema, as well as decreases in the numbers of astrocyte processes and the ability of erythrocytes in the stasis zone to stain with glycine cresol stain, were found to correlate with the mean square ethanol concentration (MSEC) in blood and urine. This allows this parameter to be assessed in histological studies of the brain. Conversely, knowledge of MSEC allows the presence of certain histological changes in the brain to be evaluated.
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Translated from Morfologiya, Vol. 146, No. 6, pp. 17–20, November–December, 2014.
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Panchenko, K.I., Panchenko, A.K. & Sukhov, D.V. Relationship between the Extent of Morphological Changes in the Brain and Blood and Urine Ethanol Concentrations. Neurosci Behav Physi 45, 970–973 (2015). https://doi.org/10.1007/s11055-015-0172-y
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DOI: https://doi.org/10.1007/s11055-015-0172-y