We report here studies in which a controlled history of sequential learning of two skills was created with the aim of identifying the pattern of activation of neurons for the first skill on formation of the second. Animals were initially trained to an operant drinking behavior requiring use of the whiskers on the left or right side (a “whisker-dependent” skill), which was followed by training to a food-procuring pedal-pressing skill not requiring use of the whiskers. The results showed that training to a food-procuring skill induced c-Fos expression in a significantly larger number of neurons in the barrel field in animals previously trained to the operant drinking (whisker-dependent) skill than in the analogous area of control animals previously trained to a non-operant drinking skill. Our data suggest that activation of c-Fos expression on repeat training also occurred in those neurons which had already become specialized in relation to the first, whisker-dependent, skill.
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Alexandrov Yu. I., Grinchenko, Yu. V., Shevchenko, D. G., et al., “A subset of cingulate cortical neurons is specifically activated during alcohol-acquisition behavior,” Acta Physiol. Scand., 171, 87–97 (2001).
Amel’chenko E. M., Zvorykina, S. V., Bezryadnov, D. V., et al., “Recovery of impaired memory and c-fos gene expression in the brains of amnestic animals in response to a reminder,” Byull. Eksperim. Biol. Med., 153, No. 5, 698–702 (2012).
Anokhin, K. V., “Molecular scenarios for the consolidation of long-term memory,” Zh. Vyssh. Nerv. Deyat., 47, No. 2, 261–279 (1997).
Dudai, Y., “The restless engram: consolidations never end,” Annu. Rev. Neurosci., 35, 227–247 (2012).
Gorkin, A. G. and Shevchenko, D. G., “Reflection of a learning history in neuron activity in the limbic cortex of rabbits,” Zh. Vyssh. Nerv. Deyat., 43, No. 1, 172–175 (1993).
Guzowski, J. F., McNaughton, B. L., Barnes, C. A., and Worley, P. F., “Environment-specific expression of the immediate-early gene Arc in hippocampal neuronal ensembles,” Nat. Neurosci., 2, 1120–1124 (1999).
Guzowski, J. F., Miyashita, T., Chawla, M. K., et al., “Recent behavioral history modifies coupling between cell activity and Arc gene transcription in hippocampal CA1 neurons,” Proc. Natl. Acad. Sci. USA, 103, No. 4, 1077–1082 (2006).
Harris, J. A., Petersen, R. S., and Diamond, M. E., “Distribution of tactile learning and its neural basis,” Proc. Natl. Acad. Sci. USA, 96, 7587–7591 (1999).
Herry, C., Ciocchi, S., Senn, V., et al., “Switching on and off fear by distinct neuronal circuits,” Nature, 454, No. 7204, 600–606 (2008).
Martínez, M. C., Alen, N., Ballarini, F., et al., “Memory traces compete under regimes of limited Arc protein synthesis: implications for memory interference,” Neurobiol. Learn. Mem., 98, 165–173 (2012).
McKenzie, S. and Eichenbaum, H., “Consolidation and reconsolidation: two lives of memories?,” Neuron, 71, 224–233 (2011).
Silva, A. J., Zhou, Y., Rogerson, T., et al., “Molecular and cellular approaches to memory allocation in neural circuits,” Science, 326, No. 5951, 391–395 (2009).
Sozinov, A. A., Laukka, S., Averkin, R. G., and Aleksandrov, Yu. I., “Conditions and cerebral support of interference on formation of the systems structure of individual experience,” in: Trends in the Development of Contemporary Psychological Sciences, A. L. Zhuravlev and V. A. Kol’tsova (eds.), Institute of Psychology, Russian Academy of Sciences, Ch. 2, pp. 343–346 (2007).
Svarnik, O. E. Alexandrov, Yu. I., Gavrilov, V. V., et al., “Fos expression and task-related neuronal activity in rat cerebral cortex after instrumental learning,” Neuroscience, 136, 33–42 (2005).
Svarnik, O. E., Bulava, A. I., Fadeeva, T. A., and Aleksandrov, Yu. I., “Patterns of reorganization of experience acquired in mono- and multistep training,” Experim. Psikhol., 4, No. 2, 5–13 (2011).
Wixted, J. T., “On common ground: Jost’s (1897) law of forgetting and Ribot’s (1881) law of retrograde amnesia,” Psychol. Rev., 111, 864–879 (2004).
Xu, T., Yu. X., Perlik, A. J., et al., “Rapid formation and selective stabilization of synapses for enduring motor memories,” Nature, 462, 915–919 (2009).
Yang, G., Pan, F., and Gan. W. B., “Stably maintained dendritic spines are associated with lifelong memories,” Nature, 462, 920–924 (2009).
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Translated from Zhurnal Vysshei Nervnoi Deyatel’nosti imeni I. P. Pavlova, Vol. 64, No. 1, pp. 77–81, January–February, 2014.
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Svarnik, O.E., Anokhin, K.V. & Aleksandrov, Y.I. Experience of a First, “Whisker-Dependent,” Skill Affects the Induction of c-Fos Expression in Somatosensory Cortex Barrel Field Neurons in Rats on Training to a Second Skill. Neurosci Behav Physi 45, 724–727 (2015). https://doi.org/10.1007/s11055-015-0135-3
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DOI: https://doi.org/10.1007/s11055-015-0135-3