The aim of the present work was to analyze changes in the numbers of labile synaptopodin-positive dendritic spines in the parietal cortex and hippocampal field CA1 and the ability of adult rats to remember after repeated transient restraint stress (5 min daily for 10 days). These parameters were compared in animals with normal development and in those subjected to hypoxia during embryogenesis (E14, 7% O2, 3 h). Shortterm and long-term memory were degraded in adult rats with normal embryogenesis subjected to restraint stress, and the number of labile spines was decreased in hippocampal field CA1 (by 17.3 ± 10.4%, p ≤ 0.05) and increased in the molecular layer of the parietal cortex (by 36.9 ± 9.2%) compared with intact control animals. Rats subjected to prenatal hypoxia, regardless of whether or not they had been subjected to restraint stress at the adult stage or not, showed impairments to both short-term and long-term memory, along with decreases in the numbers of labile spines in the hippocampus (by 22.9 ± 10.5%) and the parietal cortex (by 28.1 ± 9.3%). These results lead to the conclusion that increases in plasticity, supporting adaptive behavior in the animals, occur in neural networks in the neocortex in response to repeated transient stress only after normal brain formation during embryogenesis, while impairments to embryogenesis led to decreases in plasticity and the adaptive potentials of the nervous system in further ontogeny.
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Translated from Rossiiskii Fiziologicheskii Zhurnal imeni I. M. Sechenova, Vol. 99, No. 11, pp. 1233–1239, November, 2013.
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Vasil’ev, D.S., Dubrovskaya, N.M., Tumanova, N.L. et al. Effects of Transient Restraint Stress on the Plasticity of the Cortical Areas of the Brain and Cognitive Functions in Adult Rats with Normal and Disturbed Embryogenesis. Neurosci Behav Physi 45, 643–647 (2015). https://doi.org/10.1007/s11055-015-0123-7
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DOI: https://doi.org/10.1007/s11055-015-0123-7