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Neuroscience and Behavioral Physiology

, Volume 44, Issue 6, pp 681–686 | Cite as

Changes in Intracellular Calcium Ion Concentrations during Generation of High-Amplitude EPSP in Neurons in the Common Snail

  • A. Yu. Malyshev
  • P. M. Balaban
Article
  • 55 Downloads

Changes in intracellular calcium ion concentrations are the main trigger for most physiological processes in neurons, including changes in gene expression and the processes of synaptic plasticity. Our experiments showed that high-amplitude EPSP in common snail command neurons, like action potentials, are accompanied by marked increases in intracellular calcium ion concentrations. The amplitude of calcium signals accompanying high-amplitude EPSP in command neurons was found to depend linearly on the strength of synaptic stimulation, while the dynamics of changes in the amplitude of EPSP themselves showed marked saturation as stimulus strength increased. This means that over a certain range of changes of membrane potential, calcium signals transmit stimulus strength more adequately than the level of depolarization of the postsynaptic neuron. We suggest that calcium signals evoked by high-amplitude EPSP can induce biochemical changes in neurons, thus mediating cellular responses in the range subthreshold for action potentials.

Keywords

neurons mollusks intracellular calcium potassium channels calcium channels optical recording 

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References

  1. 1.
    P. M. Balaban and I. A. Zakharov, Learning and Development. A Common Basis for Two Phenomena [in Russian], Nauka, Moscow (1992).Google Scholar
  2. 2.
    P. G. Kostyuk and O. A. Kryshtal’, Mechanisms of the Electrical Excitability of Nerve Cells. Biological and Technical Membranes Series [in Russian], Nauka, Moscow (1982).Google Scholar
  3. 3.
    A. G. Ter-Markaryan, T. A. Palikhova, and E. N. Sokolov, “Effects of atropine and d-tubocurarine on monosynaptic connections between identified neurons in the central nervous system of the common snail,” Zh. Vyssh. Nerv. Deyat., 40, No. 1, 183–184 (1990).Google Scholar
  4. 4.
    P. M. Balaban, “Cellular mechanisms of behavioral plasticity in terrestrial snail,” Neurosci. Biobehav. Rev., 26, No. 5, 597–630 (2002).PubMedCrossRefGoogle Scholar
  5. 5.
    P. M. Balaban, N. I. Bravarenko, O. A. Maksimova, et al., “A single serotonergic modulatory cell can mediate reinforcement in the withdrawal network of the terrestrial snail,” Neurobiol. Learn. Mem., 75, No. 1, 30–50 (2001).PubMedCrossRefGoogle Scholar
  6. 6.
    T. A. Bravarenko, A. Y. Korshunova, and P. M. Malyshev, “Synaptic contact between mechanosensory neuron and withdrawal interneuron in terrestrial snail is mediated by L-glutamate-like transmitter,” Neurosci. Lett., 341, 237–240 (2003).PubMedCrossRefGoogle Scholar
  7. 7.
    E. R. Kandel, J. H. Schwartz, and T. M. Jessell, Essentials of Neural Science and Behavior, Appleton Lange, Norwalk (1995).Google Scholar
  8. 8.
    A. Y. Malyshev and P. M. Balaban, “Identification of mechanoafferent neurons in terrestrial snail: Response properties and synaptic connections,” J. Neurophysiol., 87, No. 5, 2364–2371 (2002).PubMedGoogle Scholar
  9. 9.
    H. Markram and B. Sakmann, “Calcium transients in apical dendrites evoked by single subthreshold excitatory postsynaptic potentials via low-voltage activated calcium channels,” Proc. Natl. Acad. Sci. USA, 91, 5207–5211 (1994).PubMedCentralPubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Institute of Higher Nervous Activity and NeurophysiologyRussian Academy of SciencesMoscowRussia

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