We report here immunocytochemical studies of NeuN protein expression in neurons in the substantia nigra (SN) of the human brain (n = 14, age 27–78 years). Weak positive reactions for NeuN protein were seen in some SN neurons, while other neurons were negative. Overall, reactions for NeuN protein in neurons in the human SN were weaker than in red nucleus neurons in the same sections.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
I. P. Grigor’ev, E. G. Sukhorukova, E. A. Kolos, and D. E. Korzhevskii, “Neuromelanin in substantia nigra neurons lacking tyrosine hydroxylase,” Morfologiya, 141, No. 2, 65–67 (2012).
D. E. Korzhevskii, E. S. Petrova, O. V. Kirik, et al., “Neural markers used in studies of stem cell differentiation,” Klet. Transplant. Tkan. Inzh., 5, No. 3, 57–63 (2010).
V. A. Otellin and E. B. Arushanyan, The Nigrostriatal System [in Russian], Meditsina, Moscow (1989).
J. R. Cannon and J. T. Greenamyre, “NeuN is not a reliable marker of dopamine neurons in rat substantia nigra,” Neurosci. Lett., 464, No. 1, 14–17 (2009).
S. S. Kumar and P. S. Buckmaster, “Neuron-specific nuclear antigen NeuN is not detectable in gerbil substantia nigra pars reticulate,” Brain Res., 1142, 54–60 (2007).
R. J. Mullen, C. R. Buck, and A. M. Smith, “NeuN, a neuronal specific nuclear protein in vertebrates,” Development, 116, No. 1, 201–211 (1992).
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Morfologiya, Vol. 143, No. 2, pp. 78–80, March–April, 2013.
Rights and permissions
About this article
Cite this article
Sukhorukova, E.G. Nuclear Protein NeuN in Neurons in the Human Substantia Nigra. Neurosci Behav Physi 44, 539–541 (2014). https://doi.org/10.1007/s11055-014-9947-9
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11055-014-9947-9