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Mechanisms of Protection of the Brain from Ischemic Injury by Components of Tea

Clinical physiology data and experimental results have identified the antiatherogenic, antiaggregant, antioxidant, and anti-inflammatory actions of substances present in tea. The effects of tea and its components have been described in relation to both long-term and single dosage. The roles of catechins and the specific amino acid L-theanine in the possible mechanisms of protection and prophylaxis of cerebrovascular pathologies have been demonstrated. Data are presented showing that regular consumption of green or black tea significantly decreases the risk of developing pathological changes in the cardiovascular system.

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References

  1. A. D. Denisenko, “Autoimmune complexes of lipoprotein-antibody and their role in atherogenesis,” Med. Akad. Zh., 7, No. 1, 38–44 (2007).

    Google Scholar 

  2. M. A. Zukhurova, A. V. Starkov, A. V. Starovoit, et al., “Hypoxic and pharmacological preconditioning as a mechanism of protection in focal cerebral ischemia in rats,” Regionarn. Krovoobrash. Mikrotsirkul., 9, No. 3, 84–89 (2010).

    Google Scholar 

  3. M. A. Zukhurova, A. A. Barkovskaya, V. M. Tsverina, and T. D. Vlasov, “Mechanisms of the neuroprotective effect of the green tea component L-theanine,” Regionarn. Krovoobrash. Mikrotsirkul., 9, No. 4, 67–71 (2010).

    Google Scholar 

  4. V. A. Nagornev, “Current views of the pathogenesis of atherosclerosis,” Med. Akad. Zh., 7, No. 1, 12–22 (2007).

    Google Scholar 

  5. V. I. Skvortsova, “Mechanisms of the harmful effects of cerebral ischemia and neuroprotection,” Vestnik Ros. Akad. Med. Nauk., 11, 74–81 (2003).

    Google Scholar 

  6. A. V. Fonyakin and L. A. Geraskina, “Antiplatelet therapy in the secondary prophylaxis of ischemic stroke,” Nevrol. Neiropsikh. Psikhosomat., No. 3–4, 58–63 (2009).

  7. M. Antonello, D. Montemurro, M. Bolognesi, et al., “Prevention of hypertension, cardiovascular damage and endothelial dysfunction with green tea extracts,” Am. J. Hypertens., 20, No. 12, 1321–1328 (2007).

    Article  CAS  PubMed  Google Scholar 

  8. L. Arab, W. Liu, and D. Elashoff, “Green and black tea consumption and risk of stroke: a meta-analysis,” Stroke, 40, No. 5, 1786–1792 (2009).

    Article  CAS  PubMed  Google Scholar 

  9. A. Augustyniak, A. Bylinska, and E. Skrzydlewska, “Age-dependent changes in the proteolytic-antiproteolytic balance after alcohol and black tea consumption,” Toxicol. Mech. Meth., 21, No. 3, 209–215 (2011).

    Article  CAS  Google Scholar 

  10. G. A. Batista, C. L. Cunha, M. Scartezini, et al., “Prospective double-blind crossover study of Camellia sinensis (green tea) in dyslipidemias,” Arq. Bras. Cardiol., 93, No. 2, 128–134 (2009).

    Article  Google Scholar 

  11. A. Basu, K. Sanchez, M. J. Leyva, et al., “Green tea supplementation affects body weight, lipids, and lipid peroxidation in obese subjects with metabolic syndrome,” J. Am. Coll. Nutr., 29, No. 1, 31–40 (2010).

    Article  CAS  PubMed  Google Scholar 

  12. D. H. Belitz and W. Grosch, Quimica de los Alimentos, Acribia, Zaragoza (1997).

    Google Scholar 

  13. M. Blanco, M. Rodriguez-Yáñez, T. Sobrino, et al., “Platelets, inflammation, and atherothrombotic neurovascular disease: the role of endothelial dysfunction,” Cerevasc. Dis., 20, Suppl. 2, 32–39 (2005).

    Article  Google Scholar 

  14. C. Cabrera, R. Artacho, and R. Giménez, “Beneficial effects of green tea – a review,” J. Am. Coll. Nutr., 25, No. 2, 79–99 (2006).

    Article  CAS  PubMed  Google Scholar 

  15. G. Cao, E. Sofic, and R. Prior, “Antioxidant capacity of tea and common vegetables,” J. Agric. Food Chem., 44, 3426–3431 (1996).

    Article  CAS  Google Scholar 

  16. K. Y. Chyu, S. M. Babbidge, X. Zhao, et al., “Differential effects of green tea-derived catechin on developing versus established atherosclerosis in apolipoprotein E-null mice,” Circulation, 109, No. 20, 2448–2453 (2004).

    Article  CAS  PubMed  Google Scholar 

  17. S. J. Duffy, J. F. Keaney, M. Holbrook, et al., “Short- and long-term black tea consumption reverses endothelial dysfunction in patients with coronary artery disease,” Circulation, 104, No. 2, 151–156 (2001).

    Article  CAS  PubMed  Google Scholar 

  18. N. Egashira, N. Hayakawa, M. Osajima, et al., “Involvement of GABA(A) receptors in the neuroprotective effect of theanine on focal cerebral ischemia in mice,” J. Pharmacol. Sci., 105, No. 2, 211–214 (2007).

    Article  CAS  PubMed  Google Scholar 

  19. N. Egashira, N. Ishigami, F. Pu, et al., “Theanine prevents memory impairment induced by repeated cerebral ischemia in rats,” Phytother. Res., 22, No. 1, 65–68 (2008).

    Article  CAS  PubMed  Google Scholar 

  20. K. H. Ekborg-Ott, A. Tylor, and D. W. Armstrong, “Varietal differences in the total and enantiomeric composition of theanine in tea,” J. Agric. Food Chem., 45, 353–357 (1997).

    Article  CAS  Google Scholar 

  21. H. N. Graham, “Green tea composition, consumption, and polyphenol chemistry,” Prev. Med., 21, No. 3, 334–350 (1992).

    Article  CAS  PubMed  Google Scholar 

  22. J. M. Hodgson, I. B. Puddey, T. A. Mori, et al., “Effects of regular ingestion of black tea on haemostasis and cell adhesion molecules in humans,” Eur. J. Clin. Nutr., 55, No. 10, 881–886 (2001).

    Article  CAS  PubMed  Google Scholar 

  23. J. M. Hodgson, I. B. Puddey, V. Burke, et al., “Regular ingestion of black tea improves brachial artery vasodilator function,” Clin. Sci. (London), 102, No. 2, 195–201 (2002).

    Article  Google Scholar 

  24. M. H. Hong, M. H. Kim, H. J. Chang, et al., “Epigallocatechin-3-gallate inhibits monocyte chemotactic protein-1 expression in endothelial cells via blocking NF-κB signaling,” Life Sci., 80, 1957–1965 (2007).

    Article  CAS  PubMed  Google Scholar 

  25. S. H. Ihm, J. O. Lee, S. J. Kim, et al., “Catechin prevents endothelial dysfunction in the prediabetic stage of OLETF rats by reducing vascular NADPH oxidase activity and expression,” Atherosclerosis, 206, No. 1, 47–53 (2009).

    Article  CAS  PubMed  Google Scholar 

  26. S. Inami, M. Takano, M. Yamamoto, et al., “Tea catechin consumption reduces circulating oxidized low-density lipoprotein,” Int. Heart. J., 48, No. 6, 725–732 (2007).

    Article  CAS  PubMed  Google Scholar 

  27. J. Jankun, M. Skotnicka, W. Lysiak-Szydlowska, et al., “Diverse inhibition of plasminogen activator inhibitor type 1 by theaflavins of black tea,” Int. J. Mol. Med., 27, No. 4, 525–529 (2011).

    Article  CAS  PubMed  Google Scholar 

  28. Y. R. Jin, J. H. Im, E. S. Park, et al., “Antiplatelet activity of epigallocatechin gallate is mediated by the inhibition of PLCgamma2 phosphorylation, elevation of PGD2 production, and maintaining calcium-ATPase activity,” J. Cardiovasc. Pharmacol., 51, No. 1, 45–54 (2008).

    Article  CAS  PubMed  Google Scholar 

  29. N. Jochmann, M. Lorenz, A. Krosigk, et al., “The efficacy of black tea in ameliorating endothelial function is equivalent to that of green tea,” Brit. J. Nutr., 99, 863–868 (2008).

    Article  CAS  PubMed  Google Scholar 

  30. T. Kakuda, “Neuroprotective effects of the green tea components theanine and catechins,” Biol. Pharm. Bull., 25, No. 12, 1513–1518 (2002).

    Article  CAS  PubMed  Google Scholar 

  31. T. Kakuda, A. Nozawa, A. Sugimoto, and H. Niino, “Inhibition by theanine of binding of [3H]AMPA, [3H]kainate, and [3H]MDL 105.519 of glutamate receptors,” Biosci. Biotech. Biochem., 66, No. 12, 2683–2686 (2002).

    Article  CAS  Google Scholar 

  32. W. S. Kang, I. H. Lim, D. Y. Yuk, et al., “Antithrombotic activities of green tea catechins and (–)-epigallocatechin gallate,” Thromb. Res., 96, No. 3, 229–237 (1999).

    Article  CAS  PubMed  Google Scholar 

  33. W. S. Kang, K. H. Chung, J. H. Chung, et al., “Antiplatelet activity of green tea catechins is mediated by inhibition of cytoplasmic calcium increase,” J. Cardiovasc. Pharmacol., 38, No. 6, 875–884 (2001).

    Article  CAS  PubMed  Google Scholar 

  34. S. O. Keli, M. G. Hertog, E. J. Feskens, and D. Kromhout, “Dietary flavonoids, antioxidant vitamins, and incidence of stroke: the Zutphen study,” Arch. Intern. Med., 156, No. 6, 637–642 (1996).

    Article  CAS  PubMed  Google Scholar 

  35. J. E. Klaunig, Y. Xu, C. Han, L. M. Kamendulis, et al., “The effect of tea consumption on oxidative stress in smokers and nonsmokers,” Proc. Soc. Exp. Biol. Med., 220, No. 4, 249–254 (1999).

    Article  CAS  PubMed  Google Scholar 

  36. S. C. Langley-Evans, “Antioxidant potential of green and black tea determined using the ferric reducing power (FRAP) assay,” Int. J. Food Sci. Nutr., 51, No. 3, 181–188 (2000).

    Article  CAS  PubMed  Google Scholar 

  37. S. C. Larsson, S. Männistö, M. J. Virtanen, et al., “Coffee and tea consumption and risk of stroke subtypes in male smokers,” Stroke, 39, No. 6, 1681–1687 (2008).

    Article  CAS  PubMed  Google Scholar 

  38. W. Lee, W.-K. Min, S. Chun, et al., “Long-term effects of green tea ingestion on atherosclerotic biological markers in smokers,” Clin. Biochem., 38, 84–87 (2005).

    Article  CAS  PubMed  Google Scholar 

  39. W. Liang, A. H. Lee, C. W. Binns, et al., “Tea consumption and ischemic stroke risk: a case-control study in southern China,” Stroke, 40, No. 7, 2480–2485 (2009).

    Article  PubMed  Google Scholar 

  40. P. Libby, P. M. Ridker, and A. Maseri, “Inflammation and atherosclerosis,” Circulation, 105, No. 9, 1135–1143 (2002).

    Article  CAS  PubMed  Google Scholar 

  41. G. Lill, S. Voit, K. Schrör, and A. A. Weber, “Complex effects of different green tea catechins on human platelets,” FEBS Lett., 546, No. 2–3, 265–270 (2003).

    Article  CAS  PubMed  Google Scholar 

  42. G. Y. Lip and S. J. Edwards, “Stroke prevention with aspirin, warfarin and ximelagatran in patients with non-valvular atrial fibrillation: a systematic review and meta-analysis,” Thromb. Res., 118, No. 3, 321–333 (2006).

    Article  CAS  PubMed  Google Scholar 

  43. J. Liu, C. Ying, Y. Meng, et al., “Green tea polyphenols inhibit plasminogen activator inhibitor-1 expression and secretion in endothelial cells,” Blood Coag. Fibrin., 20, No. 7, 552–557 (2009).

    Article  CAS  Google Scholar 

  44. M. Lorenz, K. Stangl, and V. Stangl, “Vascular effects of tea are suppressed by soy milk,” Atherosclerosis, 206, No. 1, 31–32 (2009).

    Article  CAS  PubMed  Google Scholar 

  45. M. Maruyama and K. Takeda, “Electrophysiologically potent noncompetitive glutamate antagonists at crayfish neuromuscular junctions are also potent inhibitors of [3H]MK801 binding to synaptic membranes from rat central nervous system,” Comp. Biochem. Physiol., 107, 105–110 (1994).

    Google Scholar 

  46. M. Mizugaki, F. Ishizawa, T. Yamazaki, and T. Hishinuma, “Epigallocatechin gallate increases the prostacyclin production of bovine aortic endothelial cells,” Prost. Lipid. Mediat., 62, 157–164 (2000).

    Article  CAS  Google Scholar 

  47. K. Nakagawa and T. Miyazawa, “Absorption and distribution of tea catechin, (–)-epigallocatechin-3-gallate, in the rat,” J. Nutr. Sci. Vitaminol. (Tokyo), 43, No. 6, 679–684 (1997).

    Article  CAS  Google Scholar 

  48. J. Oyama, T. Maeda, K. Kouzuma, et al., “Green tea catechins improve human forearm endothelial dysfunction and have antiatherosclerotic effects in smokers,” Circ. J., 74, No. 3, 578–588 (2010).

    Article  CAS  PubMed  Google Scholar 

  49. J. P. Reis, C. M. Loria, O. M. Steffen, et al., “Coffee, decaffeinated coffee, caffeine, and tea consumption in young adulthood and atherosclerosis later in life: the CARDIA study,” Arterioscler. Thromb. Vasc. Biol., 30, No. 10, 2059–2066 (2010).

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  50. M. Reto, M. E. Figueira, H. M. Felipe, and C. M. Almeida, “Chemical composition of green tea (Camellia sinensis) infusions commercialized in Portugal,” Plant Foods Hum. Nutr., 62, No. 4, 139–144 (2007).

    Article  CAS  PubMed  Google Scholar 

  51. L. Ryan and S. Petit, “Addition of whole, semiskimmed, and skimmed bovine milk reduces the total antioxidant activity of black tea,” Nutr. Res., 30, No. 1, 14–20 (2010).

    Article  CAS  PubMed  Google Scholar 

  52. R. L. Sacco, R. Adams, G. Albers, et al., “Guidelines for prevention of stroke in patients with ischemic stroke or transient ischemic attack,” Stroke, 37, No. 2, 577–617 (2006).

    Article  PubMed  Google Scholar 

  53. Y. Sakato, “The chemical constituents of tea: III. A new amide theanine,” Nippon Nogeikagaku Kaishi, 23, 262–267 (1949).

    Article  Google Scholar 

  54. Y. Sato, H. Nakatsuka, T. Watanabe, et al., “Possible contribution of green tea drinking habits to the prevention of stroke,” Tohoku J. Exp. Med., 157, No. 4, 337–343 (1989).

    Article  CAS  PubMed  Google Scholar 

  55. D. J. Son, M. R. Cho, Y. R. Jim, et al., “Antiplatelet effect of green tea catechins: a possible mechanism through arachidonic acid pathway,” Prost. Leukot. Essent. Fatty Acids, 71, No. 1, 25–31 (2004).

    Article  CAS  Google Scholar 

  56. A. Steptoe, E. L. Gibson, R. Vuononvirta, et al., “The effects of chronic tea intake on platelet activation and inflammation: a doubleblind placebo controlled trial,” Atherosclerosis, 193, No. 2, 277–282 (2007).

    Article  CAS  PubMed  Google Scholar 

  57. R. Stocker and J. F. Keaney, “Role of oxidative modifications in atherosclerosis,” Physiol. Rev., 84, No. 4, 1381–1478 (2004).

    Article  CAS  PubMed  Google Scholar 

  58. E. Sürmen-Gür, T. Gülten, Z. Serdar, and M. Colakogullari, “Chronic black tea administration protects plasma proteins, plasma, liver and kidney lipids against oxidation,” Med. Sci. Monit., 12, No. 3, BR102–BR105 (2006).

    PubMed  Google Scholar 

  59. E. Suzuki, T. Yorifuji, S. Takao, et al., “Green tea consumption and mortality among Japanese elderly people: the prospective Shizuoka elderly cohort,” Ann. Epidemiol., 129, No. 10, 732–739 (2009).

    Article  Google Scholar 

  60. J.-I. Suzuki, M. Ogawa, A. Izawa, et al., “Dietary consumption of green tea catechins attenuate hyperlipidaemia-induced atherosclerosis and systemic organ damage in mice,” Acta Cardiologica, 60, No. 3, 271–276 (2005).

    Article  PubMed  Google Scholar 

  61. J.-I. Suzuki, M. Ogawa, H. Futamatsu, et al., “Tea catechins improve left ventricular dysfunction, suppress myocardial inflammation and fibrosis, and alter cytokine expression in rat autoimmune myocarditis,” Eur. J. Heart. Failure, 9, No. 2, 152–159 (2007).

    Article  CAS  Google Scholar 

  62. J.-I. Suzuki, M. Isobe, R. Morishita, and R. Nagai, “Tea polyphenols regulate key mediators on inflammatory cardiovascular disease,” Mediat. Inflam., ID 494928 (2009).

  63. N. Tanabe, H. Suzuki, Y. Aizawa, and N. Seki, “Consumption of green and roasted teas and the risk of stroke incidence: results from the Tokamachi-Nakasato cohort study in Japan,” Int. J. Epidemiol., 37, No. 5, 1030–1040 (2008).

    Article  PubMed  Google Scholar 

  64. T. Terashima, J. Takido, and H. Yokogoshi, “Time-dependent changes of amino acids in the serum, liver, brain and urine of rats administrated with theanine,” Biosci. Biotechnol. Biochem., 63, No. 4, 615–618 (1999).

    Article  CAS  PubMed  Google Scholar 

  65. A. G. Thrift, J. J. McNeil, A. Forbes, and G. A. Donnan, “Risk factors for cerebral hemorrhage in the era of well-controlled hypertension. Melbourne Risk Factor Study (MERFS) Group,” Stroke, 27, 2020–2025 (1996).

    Article  CAS  PubMed  Google Scholar 

  66. U. J. Unachukwu, S. Ahmed, A. Kavalier, et al., “White and green teas (Camellia sinensis var. sinensis): variation in phenolic, methylxanthine, and antioxidant profiles,” J. Food Sci., 75, No. 6, C541–C548 (2010).

    Article  CAS  PubMed  Google Scholar 

  67. J. A. Vinson, K. Teufel, and N. Wu, “Green and black teas inhibit atherosclerosis by lipid, antioxidant, and fibrinolytic mechanisms,” J. Agric. Food Chem., 52, No. 11, 3661–3665 (2004).

    Article  CAS  PubMed  Google Scholar 

  68. Q. M. Wang, Q. Y. Gong, J. J. Yan, et al., “Association between green tea intake and coronary artery disease in a Chinese population,” Circ. J., 74, No. 2, 294–300 (2010).

    Article  PubMed  Google Scholar 

  69. J. Weinberger, “Prevention of ischemic stroke,” Curr. Cardiol. Rep., 4, No. 2, 164–171 (2002).

    Article  PubMed  Google Scholar 

  70. J. L. Witztum and D. Steinberg, “Role of oxidized low density lipoprotein in atherogenesis,” J. Clin. Invest., 88, No. 6, 1785–1792 (1991).

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  71. R. M. Wolfram, A. Oguogho, Y. Efthimiou, et al., “Effect of black tea on (iso)-prostaglandins and platelet aggregation in healthy volunteers,” Prost. Leukotr. Essent. Fatty Acids, 66, No. 5–6, 529–533 (2002).

    CAS  Google Scholar 

  72. L. Yochum, L. H. Kushi, K. Meyer, and A. R. Folsom, “Dietary flavonoid intake and risk of cardiovascular disease in postmenopausal women,” Am. J. Epidemiol., 149, 943–949 (1999).

    Article  CAS  PubMed  Google Scholar 

  73. J.-M. Yun, I. Jialal, and S. Devaraj, “Effects of epigallocatechin gallate on regulatory T cell number and function in obese v. Lean volunteers,” Brit. J. Nutr., 103, 1771–1777 (2010).

    Article  CAS  PubMed  Google Scholar 

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Correspondence to T. D. Vlasov.

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Translated from Rossiiskii Fiziologicheskii Zhurnal imeni I. M. Sechenova, Vol. 98, No. 8, pp. 929–942, August, 2012.

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Vlasov, T.D. Mechanisms of Protection of the Brain from Ischemic Injury by Components of Tea. Neurosci Behav Physi 44, 376–383 (2014). https://doi.org/10.1007/s11055-014-9922-5

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