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The Role of Glycogen Synthase Kinase 3 in the Mechanisms of Learning and Memory

Neuroscience and Behavioral Physiology volume 44, pages 1051–1058 (2014)Cite this article

This review covers published data on the role of GSK-3 in the mechanisms of learning and memory. The regulation of GSK-3 by phosphorylation of serine and tyrosine residues and via the Wnt signal pathway by means of disruption of axin-β-catenin complexes is described. Data on the involvement of GSK-3b in controlled NMDA-dependent long-term depression and long-term potentiation are discussed, as are the possible mechanisms of action of the enzyme via activation of NMDA receptors and AMPA endocytosis. The role of GSK-3b in the development of Alzheimer’s disease via inhibition of the Wnt signal pathway by beta-amyloid is addressed, as are the resultant increases in GSK-3b activity and subsequent hyperphosphorylation of tau and formation of neurofibrillary complexes. The behavior of animals with knockout and overexpression of the GSK-3b genes and the influences of GSK-3b inhibitors in different behavioral models are assessed.

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  1. Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow, Russia

    G. A. Grigor’yan

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Translated from Zhurnal Vysshei Nervnoi Deyatel’nosti imeni I. P. Pavlova, Vol. 63, No. 5, pp. 507–519, September–October, 2013.

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Grigor’yan, G.A. The Role of Glycogen Synthase Kinase 3 in the Mechanisms of Learning and Memory. Neurosci Behav Physi 44, 1051–1058 (2014). https://doi.org/10.1007/s11055-014-0023-2

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