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Neuroprotective Therapy with Citicoline (Ceraxon) in Patients with Ischemic Stroke

Neuroscience and Behavioral Physiology volume 43, pages 706–711 (2013)Cite this article

The dynamics of neurological symptoms were assessed using the Scandinavia Stroke Scale and functional disease outcomes with the Barthel index and modified Rankin scale in 89 patients during the acute period of ischemic stroke of moderate severity, whose treatment included citicoline (Ceraxon) i.v. and p.o. The results were compared with those from a reference group (52 patients) selected in terms of clinical and demographic parameters, who received similar treatment without citicoline. By discharge from hospital (days 21–24 of illness), there was significantly (p < 0.05) greater recovery in the study group. The efficacy of citicoline was significantly (p < 0.05) greater in patients aged less than 70 years and when citicoline was given in the first hours of illness.

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Authors and Affiliations

  1. Department of Neurology and Neurosurgery, N. I. Pirogov Russian National Research Medical University, Moscow, Russia

    M. Yu. Martynov, A. N. Boiko, P. R. Kamchatnov, A. A. Kabanov, A. N. Yasamanova, I. A. Shchukin, T. I. Kolesnikova, V. I. Chubykin, A. P. Glukhareva & E. I. Gusev

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  1. M. Yu. Martynov
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  2. A. N. Boiko
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  3. P. R. Kamchatnov
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  4. A. A. Kabanov
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  5. A. N. Yasamanova
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  6. I. A. Shchukin
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  7. T. I. Kolesnikova
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  8. V. I. Chubykin
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  9. A. P. Glukhareva
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  10. E. I. Gusev
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Correspondence to M. Yu. Martynov.

Additional information

Translated from Zhurnal Nevrologii i Psikhiatrii imeni S. S. Korsakova, Vol. 112, No. 3, Iss. II, Stroke, pp. 21–26, February, 2012.

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Martynov, M.Y., Boiko, A.N., Kamchatnov, P.R. et al. Neuroprotective Therapy with Citicoline (Ceraxon) in Patients with Ischemic Stroke. Neurosci Behav Physi 43, 706–711 (2013). https://doi.org/10.1007/s11055-013-9797-x

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  • DOI: https://doi.org/10.1007/s11055-013-9797-x

Keywords

  • ischemic stroke
  • cytoprotective therapy
  • citicoline