The psychoimmunomodulatory properties of phenotropil succinate were studied in conditions of experimental informational-physical stress in Wistar rats. Stress was modeled by alternation of two loads: physical (swimming with a load of 10% of body weight as long as could be tolerated) and informational (formation of a food-procuring behavior in a multiple-choice maze) for 20 days. The effects of phenotropil succinate on the specific and nonspecific resistance of the body were studied. Changes in the animals’ psychoemotional status during exposure to phenotropil succinate were analyzed in the elevated plus maze test and the Porsolt test. The results provide evidence that courses of phenotropil succinate can eliminate neuroimmune impairments developing in conditions of informational-physical stress.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
V. V. Abramov, T. Ya. Abramova, and V. S. Kozhevnikov, “Interaction of parameters of immunity and higher nervous activity in humans,” Dokl. Akad. Nauk., 371, No. 3, 410–412 (2000).
I. A. Afanasieva, “Measures of the B immunity system in stress in sportsmen,” Uchen. Zapiski, 5, No. 27, 3–7 (2007).
M. S. Goncharenko, “A method for evaluating lipid peroxidation,” Lab. Delo, No. 1, 6–61 (1985).
M. A. Korolyuk, L. I. Ivanova, I. G. Mairova, and V. E. Tokarev, “A method for assay of catalase activity,” Lab. Delo, No. 1, 16–19 (1988).
S. V. Magaeva, Neuroimmunophysiology, State V. N. Orekhovich Research Institute of Biomedical Chemistry Press, Moscow (2005).
K. A. Nikolskaya, “Evolutionary aspects of the intellect in vertebrates – could intellect be a factor limiting the choice of habitat?” Issledovano v Rossii: Elektron. Nauch. Zh., 143/050630, 1442–1500 (2005).
S. B. Pershin and T. V. Konchugova, Stress and Immunity [in Russian], Kron-Press, Moscow (1996).
E. V. Ten, “An express method for assaying ceruloplasmin activity in serum,” Lab. Delo, No. 6, 334–335 (1981).
S. V. Usik and N. V. Lenkova, “Bioenergetic characteristics of physical loadings of different types,” Fiziol. Zh., No. 9, 1370–1376 (1981).
R. M. Khaitov, I. S. Gushchin, B. V. Pinegin, and A. I. Zebrov, “Methodological guidelines for studies of the immunotropic activity of pharmacological substances,” in: Guidelines for the Experimental Preclinical Study of New Pharmacological Agents [in Russian], R. U. Khabriev (ed.), Moscow (2005).
N. Yu. Shunailova, “Immune parameters at different stages of adaptation to physical loading in an experimental model in animals,” Vest. Ural. Med. Akad. Nauki, No. 3, 100–103 (2006).
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Rossiiskii Fiziologicheskii Zhurnal imeni I. M. Sechenova, Vol. 97, No. 5, pp. 492–497, May, 2011.
Rights and permissions
About this article
Cite this article
Samotrueva, M.A., Tyurenkov, I.N., Teplyi, D.L. et al. Phenotropil Succinate as a Substance Correcting Neuroimmune Impairments in Conditions of Informational-Physical Stress. Neurosci Behav Physi 43, 135–138 (2013). https://doi.org/10.1007/s11055-012-9703-y
Received:
Revised:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11055-012-9703-y