Treatment of rats with dehydroepiandrosterone sulfate (DEAS) at doses of 1, 5, and 30 mg/kg were found to block cold-induced increases in blood aldosterone levels, though the effect was not dose-dependent in conditions of repeated cold exposure. This effect of DEAS involved μ opioid receptors. The blocking effect of DEAS (30 mg/kg) was also seen with single episodes of cold exposure, but without the involvement of μ opioid receptors.
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Translated from Rossiiskii Fiziologicheskii Zhurnal imeni I. M. Sechenova, Vol. 97, No. 2, pp. 214–217, February, 2011.
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Obut, T.A., Saryg, S.K., Ovsyukova, M.V. et al. Effects of Dehydroepiandrosterone Sulfate on Aldosterone Levels on Exposure to Cold. Neurosci Behav Physi 42, 651–653 (2012). https://doi.org/10.1007/s11055-012-9616-9
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DOI: https://doi.org/10.1007/s11055-012-9616-9