The aim of the present work was to study the distribution of cells expressing Musashi-1 (Msi-1) protein, which is regarded as a marker for neural stem cells, in the rat telencephalon. These cells were found to be concentrated in the subventricular proliferative zone and diffusely distributed in the striatum and hippocampus. In addition, intense reactions for Msi-1 were given by neurons in the habenular nuclei. These results are not in full agreement with existing views on the locations of neural stem cells in the brain.
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D. E. Korzhevskii, “Neurogenesis and neural stem cells,” Med. Acad. Zh., 10, No. 4, 175–182 (2010).
D. E. Korzhevskii, M. V. Lentsman, A. V. Gilyarov, et al., “Induction of nestin synthesis in rat brain cells in conditions of ischemic damage,” Morfologiya, 131, No. 1, 23–26 (2007).
A. K. Chojnacki, G. K. Mak, and S. Weiss, “Identity crisis for adult periventricular neural stem cells: Subventricular zone astrocytes, ependymal cells or both?” Nat. Rev. Neurosci., 10, No. 2, 153–163 (2009).
S. Sakakibara, Y. Nakamura, H. Satoh, and H. Okano, “RNA-binding protein Musashi2: Developmentally regulated expression in neural precursor cells and subpopulations of neurons in mammalian CNS,” J. Neurosci., 21, No. 20, 8091–8107 (2001).
Y. Yagita, K. Kitagawa, T. Sasaki, et al., “Differential expression of Musashi 1 and nestin in the adult rat hippocampus after ischemia,” J. Neurosci. Res., 69, No. 6, 750–756 (2002).
T. Zheng, G. P. Marshall, E. D. Laywell, and D. A. Steindler, “Neurogenic astrocytes transplanted into the adult mouse lateral ventricle contribute to olfactory neurogenesis, and reveal a novel intrinsic subependymal neuron,” Neurosci., 142, No. 1, 175–185 (2006).
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Translated from Morfologiya, Vol. 139, No. 2, pp. 77–79, March–April, 2011.
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Kirik, O.V., Alekseeva, O.S. & Korzhevskii, D.E. Expression of the Neural Stem Cell Marker Msi-1 in the Rat Telencephalon. Neurosci Behav Physi 42, 617–619 (2012). https://doi.org/10.1007/s11055-012-9611-1
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DOI: https://doi.org/10.1007/s11055-012-9611-1