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Methods for Studying the Blink Reflex and Its Normative Parameters

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Investigation of the blink reflex represents a contemporary and highly informative method in electroneurophysiological diagnosis. Contradictory data from clinical studies of the blink reflex show the relevance of the problem and dictate the need for forming universal approaches to methods of studying and interpreting the results obtained. The characteristics of the formation of the reflex electromyographic (EMG) components of the blink reflex of the orbicularis oculi muscle were studied during electrical stimulation of the supraorbital nerve in 31 healthy subjects. The latencies of the R1 and R2 components, the amplitude of the R1 component, and the area of the total power spectrum of the EMG discharges constituting the R2 component, the duration of the R2 component, and the latency of the R3 component were studied during the blink reflex.

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References

  1. G. N. Avakyan and U. F. Abdukhakimova, “Electrophysiological and clinical significance of the early and late components of the blink reflex and their role in diagnosis,” Zh. Nevrol. Psikhiat., 88, No. 3, 39–43 (1988).

    Google Scholar 

  2. A. V. Gnezdilov, A. V. Syrovegin, O. I. Zagorulko, and A. M. Ovechkin, Techniques of Electroneuromyographic Diagnosis in Contemporary Clinical Practice [in Russian], Nauka, Moscow (2003).

    Google Scholar 

  3. B. Aktekin, K. Yaltkaya, S. Ozkaynak, and Y. Oguz, “Recovery cycle of the blink reflex and exteroceptive suppression of temporalis muscle activity in migraine and tension-type headache,” Headache, 41, No. 2, 142–149 (2001).

    Article  PubMed  CAS  Google Scholar 

  4. M. R. Alvarado-Mallart, C. Batini, C. Buisserei-Delmas, and J. Corvisier, “Trigeminal representation of the masticatory and extraocular proprioceptors as revealed by horseradish peroxidase retrograde transport,” Exp. Brain Res., 23, 167–179 (1975).

    Article  PubMed  CAS  Google Scholar 

  5. M. Aramideh and B. W. Ongerboer de Visser, “Brainstem reflexes: electrodiagnostic techniques, physiology, normative data, and clinical application,” Muscle Nerve, 26, 14–30 (2002).

    Article  PubMed  CAS  Google Scholar 

  6. M. A. Basso and C. Evinger, “An explanation for reflex blink hyperexcitability in Parkinson’s disease. II. Nucleus raphe magnus,” J. Neurosci., 16, 7318–7330 (1996).

    PubMed  CAS  Google Scholar 

  7. M. A. Basso, A. S. Powers, and C. Evinger, “An explanation for reflex blink hyperexcitability in Parkinson’s disease. I. Superior colliculus,” J. Neurosci., 16, 7308–7317 (1996).

    PubMed  CAS  Google Scholar 

  8. G. Cruccu, G. D. Ianetti, J. J. Marx, et al., “Brainstem reflex circuits revisited,” Brain, 128, No. 2, 386–394 (2005).

    Article  PubMed  CAS  Google Scholar 

  9. G. Deuschl and A. Eisen, “Recommendations for the practice of clinical neurophysiology. IFCN guidelines,” EEG Clin. Neurophysiol., 52, Suppl. (1999).

  10. J. Ellrich, B. Bromm, and H. C. Hopf, “Pain-evoked blink reflex,” Muscle Nerve, 20, No. 3, 265–270 (1997).

    Article  PubMed  CAS  Google Scholar 

  11. J. Ellrich, O. K. Andersen, K. Messlinger, and L. Arendt-Nielsen, “Convergence of meningeal and facial afferents onto trigeminal brainstem neurons: an electrophysiological study in rat and man,” Pain, 82, 229–237 (1999).

    Article  PubMed  CAS  Google Scholar 

  12. C. Ertekin, N. Celebisoy, and B. Uluda, “Trigeminocervical reflexes elicited by stimulation of the infraorbital nerve: head retraction reflex,” J. Clin. Neurophysiol., 18, 378–385 (2001).

    Article  PubMed  CAS  Google Scholar 

  13. S. K. Jaaskelainen, H. Forssell, and O. Tenovuo, “Abnormalities of the blink reflex in burning mouth syndrome,” Pain, 73, No. 3, 344–460 (1997).

    Article  Google Scholar 

  14. H. Kaube, Z. Katsarava, S. Przywara, et al., “Acute migraine headache. Possible sensitization of neurons in the spinal trigeminal nucleus?” Neurology, 58, 1234–1238 (2002).

    PubMed  CAS  Google Scholar 

  15. J. Kimura, J. M. Powers, and M. W. Van Allen, “Reflex response of orbicularis oculi muscles to supraorbital nerve stimulation: study in normal subjects and in peripheral facial paralysis,” Arch. Neurol., 21, 193–199 (1969).

    Article  PubMed  CAS  Google Scholar 

  16. J. Kimura, R. L. Rodnitzky, and M. W. Van Allen, “Electrodiagnostic study of trigeminal nerve. Orbicularis oculi reflex and masseter reflex in trigeminal neuralgia, paratrigeminal syndrome, and other lesions of the trigeminal nerve,” Neurology, 20, 574–583 (1970).

    PubMed  CAS  Google Scholar 

  17. J. Kimura and L. W. Lyon, “Orbicularis oculi reflex in the Wallenberg syndrome: alteration of the late reflex by lesions of the spinal tract and nucleus of the trigeminal nerve,” J. Neurol. Neurosurg. Psych., 35, 228–233 (1972).

    Article  CAS  Google Scholar 

  18. J. Kimura, “Electrically elicited blink reflex in diagnosis of multiple sclerosis: Review of 360 patients over a seven-year period,” Brain, 98, 413–426 (1975).

    Article  PubMed  CAS  Google Scholar 

  19. J. Kimura, “Conduction abnormalities of the facial and trigeminal nerves in polyneuropathy,” Muscle Nerve, 5, S139–S144 (1982).

    Article  PubMed  CAS  Google Scholar 

  20. J. Kimura, J. Daube, D. Burke, et al., “Human reflexes and late responses. Report of an IFCN committee,” EEG Clin. Neurophysiol., 90, 393–403 (1994).

    Article  CAS  Google Scholar 

  21. E. Kugelberg, “Facial reflexes,” Brain, 75, 385–396 (1952).

    Article  PubMed  CAS  Google Scholar 

  22. M. Leandri, G. Cruccu, and A. Gottlieb, “Cluster headache-like pain in multiple sclerosis,” 19, 732–734 (1999).

  23. A. Lozza, J. Schoenen, and P. J. Delwaide, “Inhibition of the blink reflex R2 component after supraorbital and index finger stimulations is reduced in cluster headache: an indication for both segmental and suprasegmental dysfunction?” Pain, 71, 81–88 (1997).

    Article  PubMed  CAS  Google Scholar 

  24. C. B. L. M. Majoie, M. Aramideh, F.-J. H. Hulsmans, et al., “Correlation between electromyographic reflex and MR imaging examinations of the trigeminal nerve,” Am. J. Neuroradiol., 20, 1119–1125 (1999).

    PubMed  CAS  Google Scholar 

  25. J. J. Mars, F. Thoemke, S. Fitzek, et al., “Topodiagnostic value of blink reflex R1 changes: a digital postprocessing MRI correlation study,” Muscle Nerve, 24, No. 10, 1327–1331 (2001).

    Article  Google Scholar 

  26. H. Miwa, C. Nohara, M. Hotta, Y. Shimo, and K. Amemiya, “Somatosensory-evoked blink reflex: investigation of the physiological mechanisms,” Brain, 121, 281–291 (1998).

    Article  PubMed  Google Scholar 

  27. S. Ohara, N. E. Crone, N. Weiss, et al., “Cutaneous painful laser stimuli evoke responses recorded directly from primary somatosensory cortex in awake humans,” J. Neurophysiol., 91, 2734–2746 (2004).

    Article  PubMed  CAS  Google Scholar 

  28. B. W. Ongerboer de Visser, and G. Cruccu, “Neurophysiologic examination of the trigeminal, facial, and spinal accessory nerves in cranial neuropathies and brain stem disorders,” in: Clinical Electromyography, W. W. F. Brown and C. F. Bolton (eds.), Butterworth-Heinemann, Boston (1993), 2nd Edition, pp. 61–92.

  29. A. Romaniello, J. Valls-Solé, G. D. Ianetti, et al., “Nociceptive quality of the laser-evoked blink reflex in humans,” J. Neurophysiol., 87, 1386–1394 (2002).

    PubMed  CAS  Google Scholar 

  30. B. Rossi, G. Vignocci, M. Mazzoni, et al., “Causes of the instability of R3 component of electrically evoked blink reflex: role of the attention to the stimulation,” Electromyogr. Clin. Neurophysiol., 33, No. 1, 49–53 (1993).

    PubMed  CAS  Google Scholar 

  31. B. Rossi and M. G. Vignocchi, “Methodological considerations on the use of the blink reflex R3 component in the assessment of pain in man,” Ital. J. Neurol. Sci., 14, No. 3, 217–224 (2003).

    Article  Google Scholar 

  32. B. Rossi, R. Risalitti, and A. Rossi, “The R3 component of the blink reflex in man: a reflex response induced by activation of high thresh-old cutaneous afferents,” EEG Clin. Neurophysiol., 73, No. 4, 334–340 (1989).

    Article  CAS  Google Scholar 

  33. G. Sandrini, A. Proietti Cecchini, I. Milanov, et al., “Electrophysiological evidence for trigeminal neuron sensitization in patients with migraine,” Neurosci. Lett., 317, 135–138 (2002).

    Article  PubMed  CAS  Google Scholar 

  34. M. Tommaso, M. Guido, G. Libro, et al., “The three responses of the blink reflex in adult and juvenile migraine,” Acta Neurol. Belg., 2, 96–102 (2000).

    Google Scholar 

  35. J. Valls-Solé, N. Vila, V. Obach, et al., “Brainstem reflexes in patients with Wallenberg’s syndrome,” Muscle Nerve, 19, 1093–1099 (1996).

    Article  Google Scholar 

  36. J. Valls-Solé “Neurophysiological assessment of trigeminal nerve reflexes in disorders of central and peripheral nervous system,” Clin. Neurophysiol., 116, No. 10, 2255–2265 (2005).

    Article  PubMed  Google Scholar 

  37. J. A. Van Vliet, A. A. Vein, S. Le Cessie, et al., “Impairment of trigeminal sensory pathways in cluster headache,” Cephalalgia, 23, 414–419 (2003).

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Research Advisory Department, B. V. Petrovskii Russian Scientific Center for Surgery, Russian Academy of Medical Sciences, Moscow, Russia

    L. A. Medvedeva, A. V. Syrovegin, A. V. Gnezdilov & O. I. Zagorulko

  2. Department of Neurology and Neurosurgery, Russian State Medical University, Moscow, Russia

    G. N. Avakyan

Authors
  1. L. A. Medvedeva
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  2. A. V. Syrovegin
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  3. G. N. Avakyan
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  4. A. V. Gnezdilov
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  5. O. I. Zagorulko
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Correspondence to G. N. Avakyan.

Additional information

Translated from Zhurnal Nevrologii i Psikhiatrii imeni S. S. Korsakova, Vol. 111, No. 1, pp. 62–67, January, 2011.

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Medvedeva, L.A., Syrovegin, A.V., Avakyan, G.N. et al. Methods for Studying the Blink Reflex and Its Normative Parameters. Neurosci Behav Physi 42, 1–7 (2012). https://doi.org/10.1007/s11055-011-9524-4

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