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Analysis of Possible Information Conduction Pathways and Integration in the Basal Ganglia System Based on Their Interactions with the Zona Incerta

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Studies of the organization of projections between the zona incerta (ZI) of the midbrain and basal ganglia were performed to analyze the possible pathways conducting different information and its integration in the projection systems studied. The organization of projections between these structures in dogs revealed topical elements demonstrating the possible segregated conduction of functionally different information in the basal ganglia system. However, the most characteristic feature of these projection systems is the convergent conduction of functionally diverse information, which is evidence for the possible integration of functionally diverse information both at the level of the ZI and at the levels of all the basal ganglia structures studied here.

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References

  1. A. I. Gorbachevskaya and O. G. Chivileva, “Morphofunctional analysis of the pathways conducting information in the basal ganglia of mammals,” Usp. Fiziol. Nauk., 34, No. 2, 46–63 (2003).

    Google Scholar 

  2. A. I. Gorbachevskaya and O. G. Chivileva, “Structural organization of the zona incerta of the dog diencephalon,” Morfologiya, 128, No. 3, 11–15 (2007).

    Google Scholar 

  3. G. E. Alexander, M. R. DeLong, and P. L. Strick, “Parallel organization of functionally segregated circuits linking basal ganglia and cortex,” Ann. Rev. Neurosci., 9, 357–381 (1986).

    Article  PubMed  CAS  Google Scholar 

  4. P. Bartho, A. Slezia, V. Varga, H. Bokor, D. Pinault, G. Buzsaki, and L. Acsady, “Cortical control of zona incerta,” J. Neurosci., 27, No. 7, 1670–1681 (2007).

    Article  PubMed  CAS  Google Scholar 

  5. M. R. DeLong and T. Wichmann, “Circuits and circuit disorders of basal ganglia,” Neurol. Rev., 64, No. 1, 20–24 (2007).

    Google Scholar 

  6. S. Dua-Sharma, K. N. Sharma, and H. L. Jacobs, The Canine Brain in Stereotaxic Coordinates, MIT Press, Cambridge, MA, London (1970).

    Google Scholar 

  7. E. Garcia-Rill, “The basal ganglia and the locomotor regions,” Brain Res. Rev., 11, No. 1, 47–63 (1986).

    Article  Google Scholar 

  8. S. N. Haber, “Functional anatomy and physiology of the basal ganglia: non-motor functions,” in: Current Clinical Neurology: Deep Brain Stimulation in Neurological and Psychiatric Disorders, D. Tarsy, P. A. Vitek, P. A. Starr, and M. S. N. J. Okun (eds.), Humana Press, Totowa (2008), pp. 33–62.

    Chapter  Google Scholar 

  9. C. E. Heise, and J. Mitrofanis, “Evidence for a glutamatergic projection from the zona incerta to the basal ganglia of rats,” J. Comp. Neurol., 468, No. 3, 482–495 (2004).

    Article  PubMed  CAS  Google Scholar 

  10. J. Jimenez-Castellanos and A. M. Graybiel, “Subdivisions of the dopamine-containing A8-A9-A10 complex identified by their differential mesostriatal innervation of striosomes and extrastriosomal matrix,” Neurosci., 23, No. 1, 223–242 (1987).

    Article  CAS  Google Scholar 

  11. D. Joel and I. Weiner, “The connections of the dopaminergic system with the striatum in rats and primates: an analysis with respect to the functional and compartmental organization of the striatum,” Neurosci., 96, No. 3, 251–474 (2000).

    Article  Google Scholar 

  12. W. W. Kaelber and T. B. Smith, “Projections of the zona incerta in the cat, with stimulation controls,” Exp. Neurol., 63, No. 1, 177–200 (1979).

    Article  PubMed  CAS  Google Scholar 

  13. M. F. Kritzer, “Selective colocalization of immunoreactivity for intracellular gonadal hormone receptors and tyrosine hydroxylase in the ventral tegmental area, substantia nigra, and retrorubral fields in the rat,” J. Comp. Neurol., 379, No. 1, 247–260 (1997).

    Article  PubMed  CAS  Google Scholar 

  14. M. M. Mesulam, “Tetramethylbenzidine for horseradish peroxidase neurohistochemistry: a non-carcinogenic blue reaction product with superior sensitivity for visualizing neural afferents and efferents,” J. Histochem. Cytochem., 26, No. 2, 106–117 (1978).

    Article  PubMed  CAS  Google Scholar 

  15. J. Mitrofanis, “Some certainty for the ‘zone of uncertainty’? Exploring the function of zona incerta,” Neurosci., 130, No. 1, 1–15 (2005).

    Article  CAS  Google Scholar 

  16. A. P. Pahapill and A. M. Lozano, “The pedunculopontine nucleus and Parkinson disease,” Brain, 123, No. 9, 1767–1783 (2000).

    Article  PubMed  Google Scholar 

  17. A. Parent, Comparative Neurobiology of the Basal Ganglia, John Wiley and Sons, New York (1986).

    Google Scholar 

  18. P. Plaha,Y. Ben-Shiomo, N. K. Patel, and S. S. Gill, “Stimulation of the caudal zona incerta is superior to stimulation of the subthalamic nucleus in improving parkinsonism,” Brain, 126, No. 7, 1732–1747 (2006).

    Article  Google Scholar 

  19. T. Stefurak, D. Mikulis, H. Mayberg, A. E. Lang, S. Hevenor, P. Pahapill, J. Saint-Cyr, and A. Lozano, “Deep brain stimulation for Parkinson’s disease dissociates mood and motor circuits: a functional MRI case study,” Mov. Disord., 18, No. 12, 1508–1516 (2003).

    Article  PubMed  Google Scholar 

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Correspondence to A. I. Gorbachevskaya.

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Translated from Rossiiskii Fiziologicheskii Zhurnal imeni I. M. Sechenova, Vol. 96, No. 4, pp. 433–440, April, 2010.

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Gorbachevskaya, A.I. Analysis of Possible Information Conduction Pathways and Integration in the Basal Ganglia System Based on Their Interactions with the Zona Incerta. Neurosci Behav Physi 41, 837–842 (2011). https://doi.org/10.1007/s11055-011-9495-5

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