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The Organization of Sleep in Krushinskii–Molodkina Rats after Sleep Deprivation and Audiogenic Convulsive Seizures of Different Intensities

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The organization of sleep after audiogenic paroxysmal seizures of different intensities induced in animals with a normal daily sleep-waking cycle was studied in Krushinskii–Molodkina rats, which have an inherited predisposition to audiogenic convulsions; sleep organization was also studied after 12-h deprivation of fast-wave sleep on a platform or 6-h total sleep deprivation by waking. In all these conditions, intense audiogenic seizures with clonic or clonic-tonic convulsions produced long-lasting and significant disorders of sleep organization in rats, expressed predominantly as impairments to the functional mechanisms triggering the fast-wave phase of sleep. While paroxysmal seizures evoked after experimental sleep deprivation consisted only of motor arousal without any clear signs of convulsions, this type of seizure could even to some extent promote the faster onset of recovery after deprivation and did not induce functional disorganization of the brain system responsible for triggering and maintaining fast-wave sleep.

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References

  1. R. G. Binaiurishvili, A. M. Vein, B. G. Gafurov, and A. R. Rakhimdzhanov, Epilepsy and the Functional State of the Brain [in Russian], Meditsina, Tashkent (1985).

    Google Scholar 

  2. S. I. Vataev, “Effects of repeated audiogenic convulsive seizures on the organization of sleep in rats,” Ros. Fiziol. Zh. im. I. M. Sechenova, 91, No. 7, 740–751 (2007).

    Google Scholar 

  3. S. I. Vataev, E. P. Zhabko, N. Ya. Lukomskaya, G. A. Oganesyan, and L. G. Magazanik, “Effects of memantine on convulsive reactions and the organization of sleep in Krushinskii–Molodkina rats with inherited predisposition to audiogenic seizures,” Ros. Fiziol. Zh. im. I. M. Sechenova, 95, No. 8, 802–812 (2009).

    CAS  Google Scholar 

  4. S. I. Vataev and G. A. Oganesyan, “Effects of deprivation of fastwave sleep in rats with an inherited predisposition to audiogenic convulsive seizures,” Zh. Evolyuts. Biokhim. Fiziol., 40, No. 1, 60–66 (2004).

    CAS  Google Scholar 

  5. S. I. Vataev and G. A. Oganesyan, “Effects of total sleep deprivation in rats with an inherited predisposition to audiogenic convulsive seizures,” Zh. Evolyuts. Biokhim. Fiziol., 41, No. 1, 82–88 (2005).

    Google Scholar 

  6. I. V. Ermakova, G. D. Kuznetsova, E. V. Loseva, A. E. Sidorenkov, and M. E. Ioffe, “Use of neurotransplantation to suppress convulsive activity in rats with genetic epilepsy,” Byull. Eksperim. Biol. Med., 130, No. 9, 279–283 (2006).

    Google Scholar 

  7. I. G. Karmanova and G. A. Oganesyan, Physiology and Pathology of the Sleep-Waking Cycle, Evolutionary Aspects [in Russian], Nauka, St. Petersburg (1994).

    Google Scholar 

  8. G. A. Oganesyan and S. I. Vataev, “Effects of generalized seizures on the structure of the daily sleep-waking cycle in and the EEG in rats with an inherited predisposition to audiogenic seizures,” Ros. Fiziol. Zh. im. I. M. Sechenova, 81, No. 10, 1–8 (1995).

    Google Scholar 

  9. A. F. Semiokhina, I. B. Fedotova, and I. I. Poletaeva, “Krushinskii– Molodkina rats: a study of audiogenic epilepsy, vascular pathology, and behavior,” Zh. Vyssh. Nerv. Deyat., 56, No. 3, 298–316 (2006).

    CAS  Google Scholar 

  10. C. W. Bazil, “Sleep and epilepsy,” Semin. Neurol., 22, No. 3, 321–327 (2002).

    Article  PubMed  Google Scholar 

  11. C. L. Faingold, M. H. Millan, C. A. Boersma Anderson, and B. S. Meldrum, “Induction of audiogenic seizures in normal and genetically epilepsy-prone rats following focal microinjection of an excitant amino acid into reticular formation and auditory nuclei,” Epilepsy Res., 3, No. 3, 199–205 (1989).

    Article  PubMed  CAS  Google Scholar 

  12. C. L. Faingold, “Neuronal networks in the genetically epilepsy-prone rat,” Adv. Neurol., 79, 311–321 (1999).

    PubMed  CAS  Google Scholar 

  13. N. Garcia-Cairasco, V. C. Terra, and M. C. Doretto, “Midbrain substrates of audiogenic seizures in rats,” Behav. Brain Res., 58, No. 1–2, 57–67 (1993).

    Article  PubMed  CAS  Google Scholar 

  14. B. A. Malow and B. V. Vaughn, “Treatment of sleep disorders in epilepsy,” Epilepsy Behav., 3, No. 5, 35–37 (2002).

    Article  PubMed  Google Scholar 

  15. G. Paxinos and C. Watson, The Rat Brain in Stereotaxic Coordinates, CD-ROM, 3rd Edition, Academic Press, San Diego (1997).

    Google Scholar 

  16. B. V. Vaughn and O. F. D’Cruz, “Sleep and epilepsy,” Semin. Neurol., 24, No. 3, 301–313 (2004).

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, 44 M. Torez Prospekt, 194223, St. Petersburg, Russia

    S. I. Vataev & G. A. Oganesyan

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  1. S. I. Vataev
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  2. G. A. Oganesyan
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Correspondence to S. I. Vataev.

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Translated from Rossiiskii Fiziologicheskii Zhurnal imeni I. M. Sechenova, Vol. 96, No. 3, pp. 301–314, March, 2010.

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Vataev, S.I., Oganesyan, G.A. The Organization of Sleep in Krushinskii–Molodkina Rats after Sleep Deprivation and Audiogenic Convulsive Seizures of Different Intensities. Neurosci Behav Physi 41, 687–695 (2011). https://doi.org/10.1007/s11055-011-9473-y

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